Application of Chitosan in Oral Drug Delivery

Eftekhari, Reza Baradaran; Maghsoudnia, Niloufar; Samimi, Shabnam; Dorkoosh, Farid Abedin

doi:10.1007/978-981-15-0263-7_2

Cited by 7 publications

(2 citation statements)

References 122 publications

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“…113 Although chitosan, being a cationic biopolymer, is satisfactory in terms of its use for drug delivery applications, the faster dissolution rate in the stomach and limited drug loading pose limitations to its use as a drug carrier. 114,115 These limitations can be eliminated by modifying chitosan through phosphorylation as it improves selectivity of the drug, water solubility, and patient compliance. 71,[116][117][118] For example, clindamycin injections are painful to inject, bitter for oral use, and can cause gastrointestinal reactions.…”

Section: Drug Carrying Capacitymentioning

confidence: 99%

Phosphorylation of chitin and chitosan: A review on its significance and various synthesis routes

Geeta,

Kumar,

Shivani

et al. 2024

Polymers from Renewable Resources

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Over the past few decades, chitin and chitosan, value-added biopolymers obtained majorly from seafood wastes, have been extensively evaluated and utilized for their application in plenty of domains such as biomedical, pharmaceutical, agricultural, food processing industries, fuel cells, wastewater curing, and flame retardants. A vast number of physical, chemical, and enzymatic approaches have been followed to improve the biological activities, biocompatibility, and physicochemical properties of chitin and chitosan. Among the innumerable modifications, this article focuses primarily on the importance of phosphorylation, as it intensifies not only water solubility but also tissue regeneration, flame retardation, ionic conductivity, metal chelation, and drug-carrying abilities. Furthermore, the aim of this review is to thoroughly assess various techniques that involve the use of phosphorylating agents such as phosphoric acid, phosphorus acid, phosphorus oxychloride, phosphorus pentoxide, and the grafting method to synthesize phosphorylated derivatives of chitin and chitosan, so that a clear vision can be provided to the reader aimed at choosing a best-fit method for phosphorylation.

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Section: Drug Carrying Capacitymentioning

confidence: 99%

Phosphorylation of chitin and chitosan: A review on its significance and various synthesis routes

Geeta,

Kumar,

Shivani

et al. 2024

Polymers from Renewable Resources

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“…This unique quality enables it to adhere to mucosal surfaces, making it an excellent choice for oral drug delivery. Additionally, some chitosan derivatives, such as glycol chitosan solution or glycol chitosan-based nanoparticles, can inhibit the P-glycoprotein efflux pump (increasing the likelihood of absorption into the bloodstream) [126]. Some interesting applications of chitosan-based systems for oral delivery are discussed below.…”

Section: Oral Deliverymentioning

confidence: 99%

Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications

et al. 2023

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Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. Chitosan-based drug delivery systems have been developed for various routes of administration, including oral, ophthalmic, transdermal, nasal, and vaginal, allowing for targeted and sustained release of drugs. Additionally, chitosan has been used in numerous biomedical applications, such as bone regeneration, cartilage tissue regeneration, cardiac tissue regeneration, corneal regeneration, periodontal tissue regeneration, and wound healing. Moreover, chitosan has also been utilized in gene delivery, bioimaging, vaccination, and cosmeceutical applications. Modified chitosan derivatives have been developed to improve their biocompatibility and enhance their properties, resulting in innovative materials with promising potentials in various biomedical applications. This article summarizes the recent findings on chitosan and its application in drug delivery and biomedical science.

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Chitosan Beads for Drug Delivery

Şenel,

Şahin

2024

Advances in Polymer Science

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Application of Chitosan in Oral Drug Delivery

Cited by 7 publications

References 122 publications

Phosphorylation of chitin and chitosan: A review on its significance and various synthesis routes

Phosphorylation of chitin and chitosan: A review on its significance and various synthesis routes

Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications

Chitosan Beads for Drug Delivery

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