Application of correlation high-performance liquid chromatography to the reverse-phase separation of traces of chlorinated phenols

Smit, H.C.; Lub, T.T.; Vloon, W. J.

doi:10.1016/s0003-2670(01)83223-2

Cited by 39 publications

(10 citation statements)

References 7 publications

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“…Smit et al (12,13) have applied mechanical valves as modulators for multiplex liquid chromatography. They used conventional size columns for which minimizing valve volume is not important.…”

Section: Literature Citedmentioning

confidence: 99%

Thermal desorption modulator for capillary liquid chromatography

Jinno¹,

Carney²,

Phillips³

1986

Anal. Chem.

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Section: Literature Citedmentioning

confidence: 99%

Thermal desorption modulator for capillary liquid chromatography

Jinno¹,

Carney²,

Phillips³

1986

Anal. Chem.

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“…In correlation chromatography (CC) the usual impulse-shaped injection is replaced by multiple random injections. An example of an application is given in [9]. The resulting random response of the chromatographic system is cross-correlated with the used input function.…”

Section: Correlation Techniquesmentioning

confidence: 99%

The use of Kalman filtering and correlation techniques in analytical calibration procedures

Smit¹

1985

J. RES. NATL. BUR. STAN.

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Different chemometric methods to improve calibrations are described. A Kalman filter is applied for processing and predicting slowly varying parameters of a linear calibration graph. The results are used for the evaluation of unknown samples, and for deciding whether to calibrate again or to analyze the next unknown sample. Another approach of the calibration problem, particularly in chromatography, is the use of correlation techniques. The noise reduction property of correlation chromatography is used to extend the calibration graph to very low concentrations. Furthermore, an experimental technique to determine a calibration curve and the unknown sample simultaneously under exactly the same conditions is described.

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“…Another approach to improve sensitivity in separation science is by use of multiplexing techniques. , Those include mathematical strategies like Fourier (FT) or Hadamard transform (HT) which are already well-established in the literature for various kinds of analytical tools, e.g. gas chromatography (GC), − LC, − ion mobility, , and mass spectrometry (MS). − In separation applications, the modulation of the input information–the analyte signal–is achieved by means of pseudorandom binary sequences (PRBS) that consist of defined consecutions of “1” and “0” coding for the injection of sample and blank, respectively. − Their number of elements m is denoted by the exponent n (-bit) according to m = 2 n – 1. Cross-correlation of the overlapped detector signal with the input sequence allows, subsequently, for the deconvolution of the conventional chromatographic information resulting in an increased SNR. − The principles of Hadamard transform and cross-correlation techniques have been described in detail in the literature. ,,,, …”

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Direct Hadamard Transform Capillary Zone Electrophoresis without Instrumental Modifications

et al. 2018

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We report the first successful implementation of a multiplexing method on a standard capillary electrophoresis system with UV detection that is independent of additional hardware. This was achieved using the Hadamard transform approach and employing vial exchange and voltage suspensions for translation of pseudorandom binary sequence elements into sample and background electrolyte injections of a capillary zone electrophoresis separation. Sequences exceeding peak capacity of the capillary were subdivided into shorter subsequences measured successively and realigned afterward based on EOF marker or analyte peaks. This way, we realized and deconvoluted modulation sequences as long as 8-bit (255 injections) for two systems containing either AMP or a mixture of the nucleotides (A,C,G,U)MP resulting in electropherograms of considerably improved signal-to-noise ratio. We achieved factors of intensity enhancement of around 6.9 and 5.2, respectively (theoretical maximum 8.0). This contribution, further, presents experimental and simulation studies on the effects on zones during injection and separation when experiencing voltage suspensions. Besides analysis of EOF behavior and influence of diffusion dispersion, we also provide data on the significance of specific electrophoretic errors such as peak position shift, inconsistent sample injection, and peak broadening on the quality of the inverse Hadamard transform. Moreover, the application of our approach to the practical analysis of a milk sample is described. The results demonstrate the applicability of multiplexing on unmodified standard CE instrumentation and establish a new suitable methodology to enhance the low sensitivity of on-column UV detection in capillary electrophoresis.

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Application of correlation high-performance liquid chromatography to the reverse-phase separation of traces of chlorinated phenols

Cited by 39 publications

References 7 publications

Thermal desorption modulator for capillary liquid chromatography

Thermal desorption modulator for capillary liquid chromatography

The use of Kalman filtering and correlation techniques in analytical calibration procedures

Direct Hadamard Transform Capillary Zone Electrophoresis without Instrumental Modifications

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