Application of Crumpled Aluminum Hydroxide Nanostructures for Cancer Treatment

Abstract

The tumormicroenvironment regulates tumor progression and the spread of cancer in the body. Applications of nanomaterials that can dysregulate tumor-microenvironment are emerging as a promising anti-cancer approaches, which can improve the efficacy of existing cancer treatments. We have reported that agglomerates of radially assembled Al hydroxide crumpled nanosheets with the disordered defective surface structure have a large positive charge and therefore can lead to ion imbalance at the cell perimembranous space through the selective adsorption of extracellular anionic species. This effect was demonstrated in vitro by reduced viability and proliferationof tumor cells, and further validated in a murine melanoma cancer model. Furthermore, crumpled Al hydroxide nanostructures showed a much stronger suppressive effect on tumor growth in combination with a minimally effective dose of doxorubicin. Taken together, the described approach of tumor microenvironment dysregulation through selective adsorption properties of folded crumpled nanostructures opened a new avenue for development of innovative anticancer therapy strategies.

Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials

“…A suggested rapid assessment procedure for the introduced indicator CIN 2D was applied to the five most famous 2dNMs, which are important for biomedical applications: graphene nanosheets (GN) and graphene oxide nanosheets (GON) [82] and references within, BNN [83,84], the flat domain of the aloohene [6,[85][86][87], and a single layer of [Mg 2 Al(OH) 6 × Cl] layered double hydroxide (Mg/Al-LDH) [88,89]. One of the most commonly used electrically neutral phospholipids, POPC lipid, was used as the test one.…”

Structure and electrical potential of calcium phosphate coatings modified with aluminum oxyhydroxide nanoparticles

“…This confirms the presence of AO nanoparticles within the inner volume of the coating, which provides their gradual release during the dissolution of the coating in a human physiological medium. The small size of the nanoparticles of the initial AlN powder (≈90 nm) [21,22] allows their penetration into the interstitial spaces and pores of the CP coating. After hydrolysis of AlN [7,21,22] the AO nanoparticles of an average size of ≈100 -250 nm were formed.…”

“…The small size of the nanoparticles of the initial AlN powder (≈90 nm) [21,22] allows their penetration into the interstitial spaces and pores of the CP coating. After hydrolysis of AlN [7,21,22] the AO nanoparticles of an average size of ≈100 -250 nm were formed. An increase in the size of the formed nanoparticles allows "fixation" in the coating pore and, as a result, the release of these nanoparticles into the environment becomes difficult.…”

“…Nanoparticles have a high value of specific surface energy due to their small size, which ensures their high chemical activity [20 -22]. It is known that nanostructured aluminum oxyhydroxide (AO) is used as a sorbent in the manufacture of microbiological filters and antiseptic dressings due to its antibacterial properties [20,21]. AO nanoparticles obtained by the electric explosion method carry an electropositive charge after interaction with aqueous media, which allows them to be used to change the electrical potential of the surface of biological coatings [7,20].…”

Aluminium Nanoparticles as Efficient Adjuvants Compared to Their Microparticle Counterparts: Current Progress and Perspectives

“…It is a well-established concept that an anaerobic and acidic TME impedes infiltration of immune cells, leading to chemo-and radioresistance and immune escape. An additional mechanism by which an oncolytic effect may be achieved is manipulation of the TME using Al NPs, which have been proposed as a means to neutralize extracellular acids [59,60]. The current evidence from in vitro studies suggests Al-NPs can potentially alkalinize culture medium [61,62].…”