Application of Cytokines and Synthetic Peptides for Increase in Immunogenicity of Melioidosis Antigens

Демьянова, О. Б.; Жукова, С И; Zankovich, A. A.; Храпова, Н. П.; Rotov, K. A.; Синтюрина, Н. Н.; Snatenkov, E. A.

doi:10.21055/0370-1069-2014-3-83-85

Problemy Osobo Opasnykh Infektsii

2014

DOI: 10.21055/0370-1069-2014-3-83-85

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Application of Cytokines and Synthetic Peptides for Increase in Immunogenicity of Melioidosis Antigens

О. Б. Демьянова¹,

С И Жукова²,

A. A. Zankovich³

et al.

Abstract: B. pseudomallei 100 resistance (61.5 % of survived animals). It was concluded that it is a good practice to include bestim in the schedule of complex immunization against melioidosis.

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The influence of immunomodulators on the formation of vaccine-induced cholera immunity

Филиппенко¹,

Иванова²,

Омельченко³

et al. 2022

Journal of microbiology, epidemiology and immunobiology

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Introduction. Due to the remaining tense situation on cholera in the world, research continues on the creation of new preventive drugs, as well as ways to increase the immunogenicity of existing anti-cholera vaccines. The combined use of vaccines with immunomodulators and cytokines is successfully used for the specific prevention of various infections, including particularly dangerous ones.The aim of the work is an experimental study of the effect of immunomodulators on the immunogenic and protective activity of the cholera bivalent chemical vaccine in order to assess the possibility of their use to improve the specific prevention of cholera.Materials and methods. The parameters of cellular and humoral local and systemic immune response in experimental animals vaccinated and receiving immunotherapy, as well as the effect of immunomodulators on the protective activity of antigens that are part of the cholera bivalent chemical vaccine, were evaluated.Results. The studies revealed that the use of immunomodulators in combination with the vaccine leads to an increase in the immunogenic properties of antigens. Immunomodulators stimulate the differentiation of CD4⁺- lymphocytes, ensuring the development of an immune response mainly along the humoral pathway, increase the number of B-lymphocytes, antigen-specific antibody-forming cells, as well as secretory immunoglobulin A in the intestines of vaccinated experimental animals. It is shown that the immunomodulator glucosaminylmuramyl dipeptide increases the protective properties of the antigens that are part of the chemical cholera bivalent vaccine. It was the most effective additive, since it protected all the animals included in the experiment from generalized cholera.Conclusion. The use of immunomodulators in anti-cholera vaccination, especially with glucosaminylmuramyl dipeptide, may be one of the approaches to improving the specific prevention of cholera.

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The influence of immunomodulators on the formation of vaccine-induced cholera immunity

Филиппенко¹,

Иванова²,

Омельченко³

et al. 2022

Journal of microbiology, epidemiology and immunobiology

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The main groups of adjuvants and the prospects of their use for the specific prevention of particularly dangerous and other infectious diseases

Филиппенко

Труфанова

Иванова

et al. 2023

Journal of microbiology, epidemiology and immunobiology

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The purpose of this review is to analyze scientific data on the adjuvant properties of substances of various origin and chemical nature (adjuvants) published in recent decades and to evaluate the effectiveness of their use in the vaccination against various infections, including particularly dangerous ones. The analysis of the literature data available in PubMed, Web of Science, Scopus, eLibrary databases, indicates that the search for new substances and drugs with the ability to enhance the immune response to antigens that are part of antibacterial and antiviral registered vaccines, as well as experimental preventive drugs, is an important and promising direction. The use of various substances and compounds as adjuvants enhances the immunogenic and protective properties of vaccines, reduces the antigenic load on the human body and causes a tense immune response in individuals with reduced functioning of immune system and in the elderly. When choosing an adjuvant, it is necessary to take into account the direction of its action on the formation of both local and systemic specific immune response, depending on the nature of the pathogen.

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Application of Cytokines and Synthetic Peptides for Increase in Immunogenicity of Melioidosis Antigens

Abstract: B. pseudomallei 100 resistance (61.5 % of survived animals). It was concluded that it is a good practice to include bestim in the schedule of complex immunization against melioidosis.

Cited by 2 publications

References 0 publications

The influence of immunomodulators on the formation of vaccine-induced cholera immunity

The influence of immunomodulators on the formation of vaccine-induced cholera immunity

The main groups of adjuvants and the prospects of their use for the specific prevention of particularly dangerous and other infectious diseases

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