Application of DTI and fMRI in moyamoya disease

Hao, Xiaokuan; Liu, Ziqi; He, Shihao; Wang, Yanru; Zhao, Yuanli; Wang, Rong

doi:10.3389/fneur.2022.948830

Cited by 15 publications

(7 citation statements)

References 56 publications

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“…CP value of SWI of WD is negatively correlated with copper and iron content (Hingwala et al., 2013 , Zhou et al., 2019 ). DTI can indirectly evaluate the integrity of cerebral white matter fibers, and FA value reflects axonal and myelin injury (Hao et al., 2022 ; Tae et al., 2018 ). MRS can perform noninvasive detection of brain chemicals, and NAA is an indicator to mark the viability and density of neurons and axons (Igarashi et al., 2021 ; Whitehead et al., 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Symptom aggravation after withdrawal of metal chelating agent therapy in patients with Wilson's disease

et al. 2023

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ObjectiveTo study the aggravation of clinical symptoms after discontinuation of metal chelating agent therapy in Wilson's disease (WD) patients, analyze the causes of aggravation, and observe the prognosis.Methods40 WD patients (cerebral type 30 cases and hepatic type 10 cases) who stopped using metal chelating agent were selected, 40 WD patients with normal therapy, and 10 normal control cases were selected. All patients underwent neurological symptom evaluation using modified Young scale, Child‐Pugh liver function grading, metal metabolism, and disease typing. Magnetic sensitivity imaging (SWI), diffusion tensor imaging (DTI), and magnetic resonance spectroscopy imaging (MRS) were performed. According to the imaging results, WD patients were divided into metal deposition stage, fiber damage stage, and neuron necrosis stage. All patients were treated with metal chelating agent for 6 months.ResultsThe score of modified Young scale in drug withdrawal group was lower than that in normal treatment group before drug withdrawal (p = .032). The score of modified Young scale was higher after drug withdrawal than before (p = .011). The number of Child‐Pugh B‐grade patients after drug withdrawal was more than that before drug withdrawal and in normal treatment group. The proportion of patients in the stage of neuronal necrosis after drug withdrawal (25%) was higher than that before drug withdrawal (10%) (p = .025). After drug withdrawal, urine copper was significantly higher than that before drug withdrawal and in the normal treatment group (p = .032, .039). After the withdrawal group resumed metal chelating agent treatment, 34.2% of neurological symptoms worsened.ConclusionsWD patients showed neurological symptoms aggravation and increased liver injury after metal chelating agent withdrawal. Increased metal deposition and new nerve injury occurred in the brain. After re‐treatment, the aggravated neurological symptoms of WD patients are difficult to reverse.

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Section: Discussionmentioning

confidence: 99%

Symptom aggravation after withdrawal of metal chelating agent therapy in patients with Wilson's disease

et al. 2023

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“…The rs-fMRI involves a state of relaxation in which subjects close their eyes and avoid any structural thought activity as much as possible using blood oxygen level-dependent (BOLD) signals to measure changes in brain function ( Ten Kate et al, 2018 ). The rs-fMRI technique mainly includes amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and functional connectivity (FC; Figure 1 ; Li et al, 2021 ; Hao et al, 2022 ). The ts-fMRI involves giving subjects certain task stimuli while simultaneously performing BOLD-fMRI signal acquisition and analyzing the changes in the functional state of each brain area during the task state ( Figure 1 ; Kang et al, 2021 ).…”

Section: Brain Function Changes In Scdmentioning

confidence: 99%

Multimodal magnetic resonance imaging on brain structure and function changes in subjective cognitive decline: a mini-review

Yue,

Han,

et al. 2023

Front. Aging Neurosci.

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Subjective cognitive decline (SCD) is the initial stage of Alzheimer’s disease (AD). Early identification of SCD and its risk factors is of great importance for targeted interventions and for delaying the onset of AD. We reviewed the relevant literature on structural magnetic resonance imaging (sMRI), diffusion tensor imaging (DTI), functional magnetic resonance imaging (fMRI), and other techniques regarding SCD research in recent years. This study applied sMRI and fMRI techniques to explore abnormal brain structures and functions, which may help provide a basis for SCD diagnosis.

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“…It is primarily used for studying injuries to the white matter fiber bundle in the brain. [ 14 ] DTI involves analyzing parameters such as mean diffusivity and fractional anisotropy. In a study conducted by Fang et al, the researchers used graph theory analysis to construct structural brain networks of patients with AD, aMCI, and normal controls.…”

Section: Brain Structural Network Study Of Amcimentioning

confidence: 99%

Multimodal magnetic resonance imaging on brain network in amnestic mild cognitive impairment: A mini-review

Gao,

Yue,

et al. 2023

Medicine

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Amnestic mild cognitive impairment (aMCI) is a stage between normal aging and Alzheimer disease (AD) where individuals experience a noticeable decline in memory that is greater than what is expected with normal aging, but dose not meet the clinical criteria for AD. This stage is considered a transitional phase that puts individuals at a high risk for developing AD. It is crucial to intervene during this stage to reduce the changes of AD development. Recently, advanced multimodal magnetic resonance imaging techniques have been used to study the brain structure and functional networks in individuals with aMCI. Through the use of structural magnetic resonance imaging, diffusion tensor imaging, and functional magnetic resonance imaging, abnormalities in certain brain regions have been observed in individuals with aMCI. Specifically, the default mode network, salience network, and executive control network have been found to show abnormalities in both structure and function. This review aims to provide a comprehensive understanding of the brain structure and functional networks associated with aMCI. By analyzing the existing literature on multimodal magnetic resonance imaging and aMCI, this study seeks to uncover potential biomarkers and gain insight into the underlying pathogenesis of aMCI. This knowledge can then guide the development of future treatments and interventions to delay or prevent the progression of aMCI to AD.

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Application of DTI and fMRI in moyamoya disease

Cited by 15 publications

References 56 publications

Symptom aggravation after withdrawal of metal chelating agent therapy in patients with Wilson's disease

Symptom aggravation after withdrawal of metal chelating agent therapy in patients with Wilson's disease

Multimodal magnetic resonance imaging on brain structure and function changes in subjective cognitive decline: a mini-review

Multimodal magnetic resonance imaging on brain network in amnestic mild cognitive impairment: A mini-review

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