Application of extracorporeal shock wave therapy in nervous system diseases: A review

Guo, Jin; Hai, Hong; Ma, Yuliang

doi:10.3389/fneur.2022.963849

Cited by 20 publications

(47 citation statements)

References 150 publications

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“…rESW, also known as pneumatically-driven ballistic extracorporeal shock wave, is characterized by a stable output waveform and consistent therapeutic effects 29 . rESWT has been employed in various systemic diseases, demonstrating biological effects such as enhanced blood circulation, pain relief, and tissue repair 7 . ESWT has been shown to modulate VEGF, thereby accelerating the healing of refractory wounds, including diabetic foot ulcers, by improving blood flow and angiogenesis 30 , 31 .…”

Section: Discussionmentioning

confidence: 99%

“…(6) Incubation with primary antibody: the rabbit-derived Bach1 primary antibody (1:200; Abcam, USA) was mixed in a 1:1 ratio with Brdu (1:200; Abcam, USA), and the cells were incubated with the primary antibody mixture at 4℃ overnight. (7) The next day, the primary antibody was recovered and the cells were washed in PBST three times for 5 min each. The cells were then incubated with fluorescent secondary antibodies for 1 h at room temperature.…”

Section: Cell Immunofluorescence Stainingmentioning

confidence: 99%

“…In recent years, rESWT has not only been commonly used in treating bone and muscle diseases, but it has also demonstrated remarkable effects in treating wound, urology disease, peripheral nerve injuries, cellulite, among others 1 – 6 . Recent animal and clinical studies have revealed that rESWT exerts a significant therapeutic effect by promoting angiogenesis at the injury sites 7 – 10 . Reports suggest that rESWT improved blood flow in rats with diabetic foot ulcers 11 .…”

Section: Introductionmentioning

confidence: 99%

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rESWT promoted angiogenesis via Bach1/Wnt/β-catenin signaling pathway

Yang,

Guo,

Kang

et al. 2024

Sci Rep

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Previous reports have established that rESWT fosters angiogenesis, yet the mechanism by which rESWT promotes cerebral angiogenesis remains elusive. rESWT stimulated HUVECs proliferation as evidenced by the CCK-8 test, with an optimal dosage of 2.0 Bar, 200 impulses, and 2 Hz. The tube formation assay of HUVECs revealed that tube formation peaked at 36 h post-rESWT treatment, concurrent with the lowest expression level of Bach1, as detected by both Western blot and immunofluorescence. The expression level of Wnt3a, β-catenin, and VEGF also peaked at 36 h. A Bach1 overexpression plasmid was transfected into HUVECs, resulting in a decreased expression level of Wnt3a, β-catenin, and VEGF. Upon treatment with rESWT, the down-regulation of Wnt3a, β-catenin, and VEGF expression in the transfected cells was reversed. The Wnt/β-catenin inhibitor DKK-1 was utilized to suppress Wnt3a and β-catenin expression, which led to a concurrent decrease in VEGF expression. However, rESWT treatment could restore the expression of these three proteins, even in the presence of DKK-1. Moreover, in the established OGD model, it was observed that rESWT could inhibit the overexpression of Bach1 and enhance VEGF and VEGFR-2 expression under the OGD environment.

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Section: Discussionmentioning

confidence: 99%

Section: Cell Immunofluorescence Stainingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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rESWT promoted angiogenesis via Bach1/Wnt/β-catenin signaling pathway

Yang,

Guo,

Kang

et al. 2024

Sci Rep

Self Cite

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“…An extracorporeal shock wave (ESW) is an acoustic mechanical stimulation similar to an US wave, but it applies approximately 1,000 times the mechanical pressure ( Romeo et al, 2014 ; Guo et al, 2022 ). ESW propagate a mechanical stimulus in the treated tissue, offering a therapeutic application for various conditions, including peripheral nerve injury.…”

Section: Mechanotherapy and Peripheral Nerve Regenerationmentioning

confidence: 99%

Emerging role of extracellular vesicles and exogenous stimuli in molecular mechanisms of peripheral nerve regeneration

Izhiman,

Esfandiari

2024

Front. Cell. Neurosci.

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Peripheral nerve injuries lead to significant morbidity and adversely affect quality of life. The peripheral nervous system harbors the unique trait of autonomous regeneration; however, achieving successful regeneration remains uncertain. Research continues to augment and expedite successful peripheral nerve recovery, offering promising strategies for promoting peripheral nerve regeneration (PNR). These include leveraging extracellular vesicle (EV) communication and harnessing cellular activation through electrical and mechanical stimulation. Small extracellular vesicles (sEVs), 30–150 nm in diameter, play a pivotal role in regulating intercellular communication within the regenerative cascade, specifically among nerve cells, Schwann cells, macrophages, and fibroblasts. Furthermore, the utilization of exogenous stimuli, including electrical stimulation (ES), ultrasound stimulation (US), and extracorporeal shock wave therapy (ESWT), offers remarkable advantages in accelerating and augmenting PNR. Moreover, the application of mechanical and electrical stimuli can potentially affect the biogenesis and secretion of sEVs, consequently leading to potential improvements in PNR. In this review article, we comprehensively delve into the intricacies of cell-to-cell communication facilitated by sEVs and the key regulatory signaling pathways governing PNR. Additionally, we investigated the broad-ranging impacts of ES, US, and ESWT on PNR.

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“…Nitric oxide (NO), a signalling molecule that induces vasodilation and increased blood flow, is synthesized by the enzyme eNOS[30]. NO relaxes the smooth muscle cells in the penile arteries and increases blood flow to the corpus cavernosum, causing penile tumescence[31]. LI-ESWT can increase ENOS expression and NO generation in the penile tissue, leading to improved erectile function.…”

mentioning

confidence: 99%

Treatment Options for Erectile Dysfunction in Diabetics

Amadi,

Okolonkwo,

Jack

et al. 2023

AJBGMB

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Erectile dysfunction (ED) is defined as the persistent inability to achieve or maintain a penile erection suitable for sexual intercourse. This condition is common with diabetic males. This article comprehensively reviews various treatment options for Erectile Dysfunction (ED) in diabetic men, with a specific focus on the potential of Low-Intensity Extracorporeal Shockwave Therapy (LI-ESWT). Persistent hyperglycemia may decrease nitric oxide (NO) generation, the cycloguanosine monophosphate (cGMP) pathway, reactive free radical levels, the RhoA/Rho kinase pathway, and nerve function, all of which may be contributing factors to ED in diabetic patients. Elevated AGE expression in diabetes individuals' corpus cavernosum may result in structural alterations to the tissue, including thicker arterial walls, decreased flexibility, endothelial dysfunction, and atherosclerosis. Chronic hyperglycemia can produce nerve injury that affects both autonomic and other sensory patterns. The following are existing treatment options for ED; oral phosphodiesterase type 5 (PDE5) inhibitor, intracavernosal injection therapy, Intraurethral PGE1 suppository (IUS), Vacuum Erection Device (VED) and penile prosthesis or penile implant. Low-Intensity Extracorporeal Shockwave therapy (LI-ESWT), the treatment options for ED is a non-invasive procedure that focuses on address the root causes of ED. The mechanism underlying the efficacy of shock wave treatment is vasodilation and angiogenesis leading to improved blood flow to the penis by upregulating vascular endothelial growth factor (VEGF), nitric oxide synthase (NOS) and proliferating cell nuclear antigen. The review unveiled the success potential of (LI-ESWT) in treating diabetic impotence.

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Application of extracorporeal shock wave therapy in nervous system diseases: A review

Cited by 20 publications

References 150 publications

rESWT promoted angiogenesis via Bach1/Wnt/β-catenin signaling pathway

rESWT promoted angiogenesis via Bach1/Wnt/β-catenin signaling pathway

Emerging role of extracellular vesicles and exogenous stimuli in molecular mechanisms of peripheral nerve regeneration

Treatment Options for Erectile Dysfunction in Diabetics

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