Application of Factorial and Doehlert Designs for the Optimization of the Simultaneous Separation and Determination of Antimigraine Drugs in Pharmaceutical Formulations by RP-HPLC-UV

Jebali, Sami; Belgacem, Chaouki; Louhaichi, Mohamed R.; Bahri, Sonia; Latrous, Latifa

doi:10.1155/2019/9685750

Cited by 7 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Literature survey revealed that Doehlert design was used to optimize mobile phase composition and mobile phase flow rate in most LC studies (53)(54)(55)(56).…”

Section: Doehlert Designmentioning

confidence: 99%

Experimental design in HPLC separation of pharmaceuticals

Stojanović¹,

Krmar²,

Protić³

et al. 2021

Arhiv za farmaciju

View full text Add to dashboard Cite

Design of Experiments (DoE) is an indispensable tool in contemporary drug analysis as it simultaneously balances a number of chromatographic parameters to ensure optimal separation in High Pressure Liquid Chromatography (HPLC). This manuscript briefly outlines the theoretical background of the DOE and provides step-by-step instruction for its implementation in HPLC pharmaceutical practice. It particularly discusses the classification of various design types and their possibilities to rationalize the different stages of HPLC method development workflow, such as the selection of the most influential factors, factors optimization and assessment of the method robustness. Additionally, the application of the DOE-based Analytical Quality by Design (AQbD) concept in the LC method development has been summarized. Recent achievements in the use of DOE in the development of stability-indicating LC and hyphenated LC-MS methods have also been briefly reported. Performing of Quantitative structure retention relationship (QSRR) study enhanced with DOE-based data collection was recomended as a future perspective in description of retention in HPLC system.

show abstract

“…Literature survey revealed that Doehlert design was used to optimize mobile phase composition and mobile phase flow rate in most LC studies (53)(54)(55)(56).…”

Section: Doehlert Designmentioning

confidence: 99%

Experimental design in HPLC separation of pharmaceuticals

Stojanović¹,

Krmar²,

Protić³

et al. 2021

Arhiv za farmaciju

View full text Add to dashboard Cite

show abstract

“…The literature survey reveals that several analytical methods are reported for its quantification. Among these methods, HPLC with mass spectrometry detection 33 , with coulometric detection 34 , electrospray ionization mass spectrometry 35 , tandem mass spectrometry 36 , fluorescence detection 37,38 in pharmaceutical preparations and biological fluids and spectrophotometric methods 39,40 , mass spectrometry detection 41 and ultraperformance liquid chromatography (UPLC) 42 are a few mention worth.…”

Section: Zoledronic Acid Zolmitript Fig 1: Structure Of Drugsmentioning

confidence: 99%

Untitled

2020

IJPSR

View full text Add to dashboard Cite

Simple, sensitive, and accurate spectrophotometry method one each for estimation of five drugs viz., chloroquine phosphate (CHP), granisetron hydrochloride (GRA), rizatriptan benzoate (RIZ), zoledronic acid (ZOL) and zolmitriptan (ZOT), have been developed. The method depends upon oxidation of each drug by excess N-Bromo succinimide (NS), and subsequent determination of UN reacted NBS by Rhodamine-B dye at λ max 557 nm. Beers law is obeyed between 2-14 µg mL-1 (for CHP); 52-14 µg mL-1 (for GRA); 1-7 µg mL-1 (for RIZ); 1-7 µg mL-1 (for ZOL) & 2-14 µg mL-1 (for ZOT). This method has been applied for the determination of drugs in their pure form as well as in tablet formulations. All the methods have been validated as per ICH guidelines. INTRODUCTION: Chloroquine Phosphate: Chloroquine phosphate (CHP) is an antimalarial drug whose structure is shown in Fig. 1A and chemically knows as 7chloro-4-4-diethylamino-1-methylbutyl amino-quinoline diphosphate. CHP is also used for the treatment of amebiasis, polymyositis, sarcoidosis rheumatoid arthritis, discoid lupus erythematosus, and photosensitive diseases 1. The literature survey reveals that several analytical methods are reported for the quantification of CHP. Among these methods, British Pharmacopoeia (BP) 2 , United States Pharmacopeia (USP) 3 , UVspectro-photometry 4 , HPLC 5 , HPTLC 6 , gas chromatography 7 , polarimetry 8 and electrophoresis 9 are a few mention worth.

show abstract

Sustainable, Green, and Sensitive Spectrofluorimetric Approach for Pizotifen Maleate Detection in Tablets and Human Plasma via Photo‐Induced Electron Transfer Inhibition

Omar,

Mohamed,

Alahmadi

et al. 2024

Luminescence

View full text Add to dashboard Cite

Pizotifen maleate (PZM) is an anti‐migraine drug. Effective treatment requires accurate measurement of PZM levels in patients and constant medication concentrations in tablets. This paper presents a new spectrofluorimetric approach for detecting PZM in tablets and human blood plasma (spiked with PZM). The detection mechanism depends on the inhibition of the PZM molecule's photoinduced electron transfer (PET), resulting in a bright fluorescent intensity from PZM. Acetic acid (2.0 M) acidifies the reaction environment and causes PET inhibition. This approach detects PZM at concentrations ranging from 100 to 700 ng mL−1. Furthermore, the approach has outstanding detection and quantification limits of 30.95 and 93.78 ng mL−1, respectively. Also, the approach accurately measured PZM content homogeneity in each tablet and spiked human plasma samples without any interference. This new strategy represents a new and sensitive method for accurate PZM monitoring in different samples. Furthermore, the established fluorimetric method's greenness was evaluated.

show abstract

Application of Factorial and Doehlert Designs for the Optimization of the Simultaneous Separation and Determination of Antimigraine Drugs in Pharmaceutical Formulations by RP-HPLC-UV

Cited by 7 publications

References 42 publications

Experimental design in HPLC separation of pharmaceuticals

Experimental design in HPLC separation of pharmaceuticals

Untitled

Sustainable, Green, and Sensitive Spectrofluorimetric Approach for Pizotifen Maleate Detection in Tablets and Human Plasma via Photo‐Induced Electron Transfer Inhibition

Contact Info

Product

Resources

About