Application of Fat Grafting in Cosmetic Breast Surgery

Davis, Matthew J.; Perdanasari, Aurelia Trisliana; Abu‐Ghname, Amjed; Gonzalez, Santiago R.; Chamata, Edward; Rammos, Charalambos K.; Winocour, Sebastian

doi:10.1055/s-0039-1700958

Cited by 30 publications

(18 citation statements)

References 69 publications

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“…During the last few years, SVF-based autologous cellular therapies have been tested in several clinical settings, like scars [ 2 , 7 ], hemifacial atrophy [ 8 ], breast reconstruction [ 9 ], wound healing and cancer therapy [ 10 ], hair regrowth [ 11 ], breast augmentation [ 12 ], and in vitro applications [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Systematic Review: Allogenic Use of Stromal Vascular Fraction (SVF) and Decellularized Extracellular Matrices (ECM) as Advanced Therapy Medicinal Products (ATMP) in Tissue Regeneration

Gentile

Sterodimas

Pizzicannella

et al. 2020

IJMS

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Stromal vascular fraction (SVF) containing adipose stem cells (ASCs) has been used for many years in regenerative plastic surgery for autologous applications, without any focus on their potential allogenic role. Allogenic SVF transplants could be based on the possibility to use decellularized extracellular matrix (ECM) as a scaffold from a donor then re-cellularized by ASCs of the recipient, in order to develop the advanced therapy medicinal products (ATMP) in fully personalized clinical approaches. A systematic review of this field has been realized in accordance with the Preferred Reporting for Items for Systematic Reviews and Meta-Analyses-Protocols (PRISMA-P) guidelines. Multistep research of the PubMed, Embase, MEDLINE, Pre-MEDLINE, PsycINFO, CINAHL, Clinicaltrials.gov, Scopus database, and Cochrane databases has been conducted to identify articles and investigations on human allogenic ASCs transplant for clinical use. Of the 341 articles identified, 313 were initially assessed for eligibility on the basis of the abstract. Of these, only 29 met all the predetermined criteria for inclusion according to the PICOS (patients, intervention, comparator, outcomes, and study design) approach, and 19 have been included in quantitative synthesis (meta-analysis). Ninety-one percent of the studies previously screened (284 papers) were focused on the in vitro results and pre-clinical experiments. The allogenic use regarded the treatment of perianal fistulas, diabetic foot ulcers, knee osteoarthritis, acute respiratory distress syndrome, refractory rheumatoid arthritis, pediatrics disease, fecal incontinence, ischemic heart disease, autoimmune encephalomyelitis, lateral epicondylitis, and soft tissue defects. The information analyzed suggested the safety and efficacy of allogenic ASCs and ECM transplants without major side effects.

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Section: Introductionmentioning

confidence: 99%

Systematic Review: Allogenic Use of Stromal Vascular Fraction (SVF) and Decellularized Extracellular Matrices (ECM) as Advanced Therapy Medicinal Products (ATMP) in Tissue Regeneration

Gentile

Sterodimas

Pizzicannella

et al. 2020

IJMS

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“…Only 1 to 3 mL of fat injection is required to achieve the aesthetic goal. 12,13 The space for fat injection is considerably smaller in the lower eyelid, and because of its thin and less elastic skin texture, the injected fat space may be more restricted. The fat graft in lower eyelid can be distributed equally as a thinner layer with theologically better nutrition supplement.…”

Section: Discussionmentioning

confidence: 99%

Oil Cyst Formation after Lower Blepharoplasty with Fat Grafts

Huang

Yen

et al. 2022

Ann Plast Surg

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Background: Fat grafting is increasingly used as an adjuvant surgery to blepharoplasty to refill the volume loss of an aged face and promote cellular regeneration. Complications, such as hematoma, infection, seroma, and palpable mass, may occur. We collected the patients that underwent lower blepharoplasty combined with fat graft to evaluate the incidence of oil cyst formation in the lower eyelid and to identify risk factors. Material and Methods: A retrospective review was performed of all patients who underwent lower or total blepharoplasty combined with fat graft at the authors' institution between January 2018 and June 2020. Complication rates were observed, and associations between preoperative variables and outcomes were assessed. Results: A total of 119 patients were included in the series (all bilateral, 238 eyelids). The average patient age was 54.88 ± 11.94 years, and the average grafted fat was 1.88 ± 1.0 mL. On a per-eyelid basis for all patients, the complication rate of oil cyst formation was 6.72% (16 of 238 eyelids). The occurrence of oil cyst formation was associated with hypertension ( P = 0.012; adjusted odds ratio, 9.27; 95% confidence interval, 1.62-52.99) and diabetes mellitus ( P = 0.005; adjusted odds ratio, 14.02; 95% confidence interval, 2.22-88.45), but not associated with anticoagulants use ( P = 0.931), age ( P = 0.784), sex ( P = 0.317), or fat volume ( P = 0.215). The mean interval between the fat graft procedure and oil cyst noted was 236.5 ± 118.9 days. Conclusions: Oil cyst in lower eyelid can be defined as a palpable, firm, and persistent subcutaneous cystic lesion found postoperatively in any size during physical examination. The complication rate of oil cyst formation occurring after lower blepharoplasty with autologous fat grafting is 6.72%. Hypertension and diabetes mellitus maybe are risk factors of oil cyst formation. Steroid injection, needle capsulotomy, liposuction, and excision are safe and effective treatments. Reduce surgical trauma by diminishing anterior lamina trauma and capsulopalpebral fascia repair might decrease the complication rate of oil cyst formation.Transconjunctival lower blepharoplasty with fat graft or 2-stage surgery may be a choice to prevent oil cyst formation.

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“…Previous studies have revealed that resistance to platinum-based chemotherapy may be due to somatic reversion mutations or intragenic deletions that restore BRCA1 or BRCA2 function in breast cancer [32]. Cytochromes P450s (CYPs) are composed of a superfamily which catalyze the metabolism of drugs and other substances.…”

Section: Discussionmentioning

confidence: 99%

A Network Pharmacological analysis of Baishao in clinical treatment of breast cancer

2022

Preprint

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Background: Baishao has been applied into clinical treatment of breast cancer. Network pharmacology revealed multiple and complicated correlations among chemical compounds, genes, proteins and predicted possible pathways relating therapeutic targets. This study aims to predict the pharmacological mechanism of Baishao in the treatment of breast cancer by network using pharmacological method. Methods：Major chemical constituents of Baishao were obtained from TCMSP database. Uniport database was used for the extraction of gene names of targeted sites. Target sites of breast cancer was obtained from CTD database. GO and KEGG analysis for targets were performed using DAVID database. Cytoscape 3.7.2 was used to conduct the‘drug-compound-target-disease’ network. Results: A total of 70 target genes were found between breast cancer and Baishao. GO analysis showed that the biological functions of common target genes of breast cancer and Baishao include response to steroid hormones, response to toxic substances, response to xenobiotic stimulus, response to antibiotic and response to lipopolysaccharide. Enrichment of KEGG signaling pathways are mainly related with platinum drug resistance，metabolism of xenobiotics by cytochrome P450，NF-kappa B signaling pathway，steroid hormone biosynthesis and antifolate resistance pathways.Conclusion: The network pharmacology reveals the complicated effects of Baishao on breast cancer, providing multi target sites and pathways for the underlying mechanism studying of the effects of Baishao on breast cancer.

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Application of Fat Grafting in Cosmetic Breast Surgery

Cited by 30 publications

References 69 publications

Systematic Review: Allogenic Use of Stromal Vascular Fraction (SVF) and Decellularized Extracellular Matrices (ECM) as Advanced Therapy Medicinal Products (ATMP) in Tissue Regeneration

Systematic Review: Allogenic Use of Stromal Vascular Fraction (SVF) and Decellularized Extracellular Matrices (ECM) as Advanced Therapy Medicinal Products (ATMP) in Tissue Regeneration

Oil Cyst Formation after Lower Blepharoplasty with Fat Grafts

A Network Pharmacological analysis of Baishao in clinical treatment of breast cancer

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