Application of Flow-Through Dissolution Method for the Evaluation of Oral Formulations of Nifedipine

Dynamic Dissolution Testing To Establish In Vitro/In Vivo Correlations for Montelukast Sodium, a Poorly Soluble Drug

“…The flow through method was chosen because of its ability to simulate the in vivo hydrodynamics better compared with the USP Apparatus 1 or 2, thus allowing a more close simulation of the pH gradient in the GI tract (17,18). Dissolution tests were also performed in the USP Apparatus 2 using FaSSIF and the USP-SIF.…”

In vitro methods to assess drug precipitation

“…Compared with USP I/II dissolution methods, FTC methods have the advantage of allowing a change in the dissolution medium during each run, which allows for better simulation of the pH gradient and fluids associated with transit throughout the gastrointestinal tract (Thoma and Ziegler, 1998). Also, they simulate in vivo hydrodynamics more closely than the USP I/II dissolution methods (Perng et al, 2003;Qureshi et al, 1994), and demonstrate good in vitro/in vivo correlations (Derendorf et al, 1983;Ikegami et al, 2003;Qureshi et al, 1994;Sunesen et al, 2005). Another advantage is that FTC methods at low flow rates are more sensitive to detect differences in the disintegration properties than other USP dissolution methods (Wennergren et al, 1989).…”

“…USP dissolution FTC methods have been used to evaluate drug dissolution/precipitation of various oral solid dosage forms (Emara et al, 2000;Wirbitzki, 1990, 1993;Nicklasson et al, 1987;Perng et al, 2003;Phillips et al, 1989;Qureshi et al, 1994;Sunesen et al, 2005;Wennergren et al, 1989). Compared with USP I/II dissolution methods, FTC methods have the advantage of allowing a change in the dissolution medium during each run, which allows for better simulation of the pH gradient and fluids associated with transit throughout the gastrointestinal tract (Thoma and Ziegler, 1998).…”

Flow-Through Cell Method and IVIVR for Poorly Soluble Drugs

“…Data acquired via FTC could be correlated well to that of the paddle method (13,40) and to in vivo data (41)(42)(43)(44). Because of the widespread development of poorly soluble compounds in the pharmaceutical industry, the FTC will gain importance.…”