Application of halloysite clay nanotubes as a pharmaceutical excipient

Yendluri, Raghuvara; Otto, Daniel P.; Villiers, Melgardt M. de; Винокуров, В. А.; Lvov, Yuri

doi:10.1016/j.ijpharm.2017.02.055

Cited by 103 publications

(50 citation statements)

References 19 publications

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“…1a). There are several elds of application for this smart nanomaterial, including drug transport and delivery, 10,[13][14][15][16][17][18][19] environmental remediation, 20-26 as a ller in polymeric matrices, 27-30 ame retardant 31 and support for catalysts 13,23 (Fig. 1b).…”

Section: 12mentioning

confidence: 99%

Halloysite nanotubes as support for metal-based catalysts

Massaro,

Colletti,

Lazzara

et al. 2017

J. Mater. Chem. A

255

106

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Halloysite nanotubes (HNTs) are clay minerals with a hollow nanotubular structure. There is growing interest in these nanomaterials, due to their biocompatibility, potential applications and availability. The surface Moreover, the presence of an empty lumen opens new perspectives for the production of nanoarchitectures with synergistic catalytic effects, due to the increase in local concentrations and confinement. The main focus of this review is the research on modified halloysite nanotubes for the preparation of valuable supports for metal nanoparticles and their applications in catalytic processes.

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Section: 12mentioning

confidence: 99%

Halloysite nanotubes as support for metal-based catalysts

Massaro,

Colletti,

Lazzara

et al. 2017

J. Mater. Chem. A

255

106

View full text Add to dashboard Cite

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“…Hence, HNTs attracted a lot of attention in biological medicine, biological science, and technology. HNTs were used as multi-purpose excipient to improve the stability of drugs and to achieve controlled release [42]. They possess a special periodic multilayer with the structure of gibbsite octahedral (Al-OH) in internal surface and siloxane (Si-O-Si) on external surface [43].…”

Section: As the Nanocarriers For Drug Deliverymentioning

confidence: 99%

Recent Advances on Surface Modification of Halloysite Nanotubes for Multifunctional Applications

et al. 2017

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Halloysite nanotubes (HNTs) are natural occurring mineral clay nanotubes that have excellent application potential in different fields. However, HNTs are heterogeneous in size, surface charge, and formation of surfacial hydrogen bond, which lead to weak affinity and aggregation at a certain extent. It is very important to modify the HNTs' surface to expand its applications. In this review, the structural characteristics, performance, and the related applications of surface-modified HNTs are reviewed. We focus on the surface-modified variation of HNTs, the effects of surface modification on the materials and related applications in various regions. In addition, future prospects and the meaning of surface modification were also discussed in HNTs studies. This review provides a reference for the application of HNTs modifications in the field of new nanomaterials.

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“…They are characterized by high mechanical strength and modulus, and due to their hollow nanostructure they are widely used for loading and controlled release of functional compounds (Makaremi et al, 2017;Yang et al, 2016;Huang et al, 2016;Saif and Asif, 2015;Lvov et al, 2016a). HNTs are used in, e.g., self-healing anticorrosive coatings (Wei et al, 2015), hydrogen production and storage (Sahiner and Sengel, 2017;Jin et al, 2017), pharmaceutical excipients (Hanif et al, 2016;Lvov et al, 2016b;Yendluri et al, 2017), biomedical applications Bonifacio et al, 2017), cosmetics (Saif and Asif, 2015), active food packaging materials (Shemesh et al, 2016;Tas et al, 2017;Krepker et al, 2017), water treatment (Yu et al, 2016), and for improvement the mechanical properties and thermal stability of polymer composites (Liu et al, 2014). Globally, HNTs annual production is over 50,000 metric tonnes (Lvov et al, 2008), which is similar to that of carbon fibers (40,000 t/y; Gutiérrez and Bono, 2013), and approximately 10 times higher than the production of carbon nanotubes which is only ca.…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure during handling and loading of halloysite nanotubes – A case study of counting nanofibers

et al. 2018

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A B S T R A C THalloysite nanotubes (HNTs) are abundant naturally-occurring hollow aluminosilicate clay mineral fibers with a typical diameter < 100 nm and an aspect ratio of up to 200. Here we assessed the potential inhalation exposure to HNTs in an industrial research laboratory. Inside a fume hood, ten times 100 g of HNTs were poured at rate of 0.5 kg min . Inside the fume hood, the respirable mass concentration was 143 μg m −3 including background particles.Outside the fume hood we did not measure elevated concentrations. We classified 1895 particles according to their length and aspect ratio. Five particles were in aspect ratio > 3 and in length > 2 μm. These particles were agglomerated and/or aggregated particles where the longest individual fiber was 2 μm in length. The occupational exposure limits for refractory mineral fibers vary from 0.1 to 2 fibers cm −3. Following standard protocols for fiber analysis, detection of 0.1 fibers cm −3 would require analysis on 4 × 10 4 images when the filter loading is good. Thus, the fiber sampling and quantification procedures needs to be improved significantly if nanofibers < 100 nm in diameter are included in regulatory exposure assessment. Due to very limited toxicological information of HNTs we recommend avoiding inhalation exposure.

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Application of halloysite clay nanotubes as a pharmaceutical excipient

Cited by 103 publications

References 19 publications

Halloysite nanotubes as support for metal-based catalysts

Halloysite nanotubes as support for metal-based catalysts

Recent Advances on Surface Modification of Halloysite Nanotubes for Multifunctional Applications

Occupational exposure during handling and loading of halloysite nanotubes – A case study of counting nanofibers

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