Application of HIF‐1α by gene therapy enhances angiogenesis and osteogenesis in alveolar bone defect regeneration

Zhang, Yang; Huang, Jiao; Wang, Chao; Zhang, Yan; Hu, Changhong; Li, Guangyue; Xu, Ling

doi:10.1002/jgm.2876

Cited by 16 publications

(7 citation statements)

References 28 publications

(32 reference statements)

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“…Hypoxia is an important factor that induces ECs toward the formation of functional vasculature supporting blood supply [95,96]. The in vitro and in vivo effects of HIF-1α on osteogenesis and angiogenesis have been in-depth studied [97][98][99][100][101][102][103]. Wu et al [104] incorporated Cu within mesoporous bioactive glass (MBG) scaffolds with large pores (300-500 μm) and well-ordered mesopores (5 nm), and investigated the effects of Cu-induced hypoxia on hMSCs.…”

Section: Coppermentioning

confidence: 99%

Materials roles for promoting angiogenesis in tissue regeneration

Lee

Parthiban

Jin

et al. 2021

Progress in Materials Science

116

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Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of tissueengineered constructs. Although many biochemical signaling molecules have been used, their biological functions in vivo are known to be limited, mainly due to their short lifetime and poor activity. Matrices (or engineered biomaterials), beyond the biochemical signals, play pivotal roles in stimulating angiogenic processes. Here we discuss the proangiogenic effort taken to repair and regenerate various tissues including skin, bone, muscle and nerve, focusing on the roles of engineered matrices. This includes the design of pore structure and physico-chemical properties (nanotopology, stiffness, chemistry and degradability), the tailoring of matrices for proper presentation of growth factors and their crosstalks with adhesion ligands, the controlled and sustained delivery of angiogenic molecules and metallic ions, and the engineering of cells and construction of prevascularized tissues. Collectively, the materials-driven strategies are envisaged

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Section: Coppermentioning

confidence: 99%

Materials roles for promoting angiogenesis in tissue regeneration

Lee

Parthiban

Jin

et al. 2021

Progress in Materials Science

116

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“…A recent animal study reported new bone and vessel formation induced by the over-expression of HIF-1α through adenovirus, leading to enhanced alveolar bone defect regeneration. [30] Cementoblastic differentiation of human dental stem cells, a key cellular mechanism concerning periodontal regeneration, was reported to be stimulated by hypoxia in a HIF-1dependent manner. [31] The mechanisms underlying the role of HIF-1 and periodontal defense/pathogenesis, however, remain elusive.…”

Section: Co-relation With Cytokinesmentioning

confidence: 99%

Hypothesis: Relationship between Coronavirus Disease-19 and Periodontal status

Ligade

Shah

2021

JGOH

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Coronavirus disease 2019 (COVID-19) is a global pandemic affecting 185 countries and >18.8 million patients worldwide as of July 2020. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-2) and majorly manifesting as a hypoxic condition in the affected patients. It has shown to multiply rapidly among patients showing other debilities, majorly hypertension, and diabetes mellitus. Periodontitis is defined as a multifactorial disease predominantly governed by microbial dysbiosis and having risk factors as the presence of systemic pathology, decline in immunity, and increased stress. Keeping these factors as a plausible threat for periodontitis, there can be a postulation made that periodontitis can act as a probable risk factor for COVID-19. Limited resources and novelty of the disease hold back any confirmation of the co-relation.

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“…It was suggested that HIF, HIF mimicking agents, or HIF stabilizing agents were considered triggers for the initiation and promotion of angiogenic-osteogenic coupling [100,101]. A recent animal study reported new bone and vessels formation induced by the overexpression of HIF-1α via adenovirus, leading to enhanced alveolar bone defect regeneration [102]. A similar result was reported from a study investigating bone loss arrest in ovariectomized C57BL/6 J mice via activated HIF-1α and Wnt/β-catenin signaling pathways [103].…”

Section: Hif and Bone Homeostasismentioning

confidence: 99%

Role of the Hypoxia-Inducible Factor in Periodontal Inflammation

Wang¹,

Chen²,

Leung³

2017

Hypoxia and Human Diseases

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Human periodontitis is a chronic inlammatory disease induced by opportunistic Gramnegative anaerobic bacteria at the tooth-supporting apparatus. Within the gingivitisafected sulcus or periodontal pocket, the resident anaerobic bacteria interact with the host inlammatory reactions leading to a lower oxygen or hypoxic environment. A cellular/tissue oxygen-sensing mechanism and its appropriate regulation are needed to assist tissue adaptation to natural/pathology-induced variations in oxygen availability. In this chapter, we reviewed the biological relevance of hypoxia in periodontal/oral cellular development, epithelial barrier function, periodontal inlammation, and immunity. The role of hypoxia-inducible factor-1α in pathogen-host cross talk and alveolar bone homeostasis was also discussed. The naturally occurring pathophysiological process of hypoxia appeared to entail fundamental relevance for periodontal defense and regeneration.

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Application of HIF‐1α by gene therapy enhances angiogenesis and osteogenesis in alveolar bone defect regeneration

Abstract: Overexpression of HIF-1α by gene therapy may be a useful method for enhancing alveolar bone defect osteogenesis and angiogenesis. Copyright © 2016 John Wiley & Sons, Ltd.

Cited by 16 publications

References 28 publications

Materials roles for promoting angiogenesis in tissue regeneration

Materials roles for promoting angiogenesis in tissue regeneration

Hypothesis: Relationship between Coronavirus Disease-19 and Periodontal status

Role of the Hypoxia-Inducible Factor in Periodontal Inflammation

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