Application of High-Intensity Focused Ultrasound for the Treatment of Vascular Anomalies: An Experimental Study in a Cockscomb Model

Wang, S.; Zhang, J.; Li, C.; Jin, Xiuli; Guo, Chuanfa; Wang, Z.

doi:10.1055/s-2008-1038959

Cited by 4 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…New treatment opportunities for HIFU are constantly evolving, [20][21][22][23] and the feasibility of HIFU for the treatment of VMs has been investigated by other groups, with encouraging initial results. [24][25][26] Most of these studies used MRI guidance to direct and deliver HIFU. Although MRI-guided HIFU offers exquisite tissue contrast and accurate quantitative feedback from the targeted region, it has significant difficulties in widespread clinical adoption, including the high cost and technical equipment requirements.…”

Section: Discussionmentioning

confidence: 99%

Imaging of vascular malformations with a high-intensity focused ultrasound probe for treatment planning

Danahey

Seip

Lee

et al. 2021

Journal of Vascular Surgery: Venous and Lymphatic Disorders

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Imaging of vascular malformations with a high-intensity focused ultrasound probe for treatment planning

Danahey

Seip

Lee

et al. 2021

Journal of Vascular Surgery: Venous and Lymphatic Disorders

View full text Add to dashboard Cite

“…The concept of exposing a higher thermal dosage than the critical value of induced coagulation of a tumour vessel has been proposed. However, it was found that the coagulation process is accompanied by vessel rupture (Wang et al 2008). This may also cause inflammation, which results in uncertainty about treatment.…”

Section: Introductionmentioning

confidence: 99%

Inducing occlusion effect in Y-shaped vessels using high-intensity focused ultrasound: finite element analysis and phantom validation

Jiang

Wu²,

2012

Computer Methods in Biomechanics and Biomedical Engineering

View full text Add to dashboard Cite

High-intensity focused ultrasound (HIFU) surgery offers a truly non-invasive treatment method with no skin incision, but precise targeting of tumour tissues for thermotherapy. Clinical experience reveals that the efficacy of tumour destruction not only involves in coagulating necrosis, but also involves in damaging the tumour vessels, which play an important role in tumour progression. These vessels take the elevated temperature away by perfusion, resulting in uncertainty of the occlusion effect during HIFU treatment. In this study, a Y-shaped vessel model comprising common and tumour vessels and an indirect fabrication method are proposed. The physical properties of the fabricated vessel phantom are measured and compared with human tissue. Simulation is performed using finite element modelling according to the tissue parameter, perfusion rate of the tumour vessel and treatment parameters including power intensity and exposure duration. The phantom experiments are carried out with perfusion of egg white to validate the threshold time prediction obtained from the simulation results. Our findings reveal that the threshold time obtained from experiments is consistent with the simulated one.

show abstract

“…It offers a sufficient time for local thermal diffusion and heat dissipation from the target region during the exposure. Even if a surgeon proposes to expose higher HIFU energy on the tumor vessel, it may be accompanied by the risk of tumor vessel rupture (Wang et al , 2008). This is because the concentrated pressure field on the focal region induced by HIFU energy exceeds the maximum stress of vessel tissue.…”

Section: Introductionmentioning

confidence: 99%

Vessel phantom fabrication using rapid prototyping technique for investigating thermal dosage profile in HIFU surgery

Jiang

2010

Rapid Prototyping Journal

View full text Add to dashboard Cite

PurposeThe purpose of this paper is to propose a method for fabricating tumor vessel phantom and then investigate the thermal dosage profile caused by high‐intensity‐focused ultrasound (HIFU) surgery.Design/methodology/approachIn this paper, a thermal sensitive powder has been added to silicon‐based gel as a vessel phantom raw material for displaying the thermal dosage profile caused by HIFU. A fused deposition modeling system was used for fabricating the shell casting mold and the vessel arbor mold. The arbor prototype, made of wax, was solidified in the cavity of vessel arbor mold. The vessel phantom object embedded with the arbor prototype was created in the shell mold casting process. The vessel phantom was obtained by immersing the vessel phantom object into hot water (65°C) for melting the vessel arbor prototype. A HIFU experiment has been conducted for verifying the feasibility of displaying the thermal dosage profile of the fabricated vessel phantom. The HIFU experimental parameters including the driving power of HIFU transducer, ultrasound exposure duration and volume flow rate were used for investigating the thermal dosage variation by the perfusion of vessel phantom.FindingsThe properties of fabricated mimicking phantom agree well with those of human tissue. The experimental results show that the proposed method can fabricate the Y‐type vessel phantom. The proposed method has been proved as a promising fabrication process in fabricating the vessel phantom and it displays the thermal dosage profile in HIFU experiment.Originality/valueThe proposed method and the developed experimental apparatus are helpful for pre‐clinical HIFU surgery.

show abstract

Application of High-Intensity Focused Ultrasound for the Treatment of Vascular Anomalies: An Experimental Study in a Cockscomb Model

Abstract: HIFU exposure is effective in destroying the vascular targeted anomaly with no skin burns, bleeding, large vessel ruptures or other complications. HIFU is feasible, noninvasive and safe for the treatment of vascular anomalies, but clinical trials are necessary.

Cited by 4 publications

References 26 publications

Imaging of vascular malformations with a high-intensity focused ultrasound probe for treatment planning

Imaging of vascular malformations with a high-intensity focused ultrasound probe for treatment planning

Inducing occlusion effect in Y-shaped vessels using high-intensity focused ultrasound: finite element analysis and phantom validation

Vessel phantom fabrication using rapid prototyping technique for investigating thermal dosage profile in HIFU surgery

Contact Info

Product

Resources

About