This paper investigates the issue of beam misalignment in curved continuous beam bridges. Taking the D0 to D6 spans of the Gongbin Road viaduct as the basis, the main influencing factors causing misalignment in curved beam bridges are analyzed and the causes of transverse and longitudinal misalignment in curved beam bridges are calculated and analyzed using Midas/Civil finite element simulation software. The results indicate that the main influencing factor causing misalignment in the operation of curved continuous beam bridges is the system temperature, with the displacement caused by it being larger than the cumulative displacement caused by self-weight, construction phase, gradient load, vehicle load, and bearing settlement. During operation, the failure of expansion joints changes the boundary conditions of the beam, preventing the bridge from freely expanding and contracting longitudinally under temperature load. As a result, the transverse displacement increases to 2-3 times the normal working state of the expansion joint, leading to beam misalignment.