Application of hyaluronic acid as carriers in drug delivery

Huang, Gangliang; Huang, Hualiang

doi:10.1080/10717544.2018.1450910

Cited by 352 publications

(163 citation statements)

References 49 publications

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“…Binding of low‐MW HA nanoparticles to THP‐1 cells is associated with higher CD44 expression and has been correlated positively to binding of soluble and (siRNA‐loaded) HA nanoparticles, but negatively with HA internalization . Because of their biocompatibility, HA particles have been used extensively in the development of vehicles for cancer therapeutics, delivering nucleic acids, peptides, and other applications . Conjugation and surface modification are mainly facilitated by carboxylic acid coupling chemistry.…”

Section: Immunomodulation By Naturally Derived Ecmsmentioning

confidence: 99%

Extracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering

Rowley

Nagalla

Wang

et al. 2019

Adv Healthcare Materials

135

123

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The extracellular matrix (ECM) is a complex and dynamic structural scaffold for cells within tissues and plays an important role in regulating cell function. Recently it has become appreciated that the ECM contains bioactive motifs that can directly modulate immune responses. This review describes strategies for engineering immunomodulatory biomaterials that utilize natural ECM‐derived molecules and have the potential to harness the immune system for applications ranging from tissue regeneration to drug delivery. A top‐down approach utilizes full‐length ECM proteins, including collagen, fibrin, or hyaluronic acid‐based materials, as well as matrices derived from decellularized tissue. These materials have the benefit of maintaining natural conformation and structure but are often heterogeneous and encumber precise control. By contrast, a bottom‐up approach leverages immunomodulatory domains, such as Arg–Gly–Asp (RGD), matrix metalloproteinase (MMP)‐sensitive peptides, or leukocyte‐associated immunoglobulin‐like receptor‐1(LAIR‐1) ligands, by incorporating them into synthetic materials. These materials have tunable control over immune cell functions and allow for combinatorial approaches. However, the synthetic approach lacks the full natural context of the original ECM protein. These two approaches provide a broad range of engineering techniques for immunomodulation through material interactions and hold the potential for the development of future therapeutic applications.

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Section: Immunomodulation By Naturally Derived Ecmsmentioning

confidence: 99%

Extracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering

Rowley

Nagalla

Wang

et al. 2019

Adv Healthcare Materials

135

123

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“…[10][11][12][13] The advent of ''click'' chemistry and the implementation of ''precision macromolecular synthesis'' concepts, together with the developments in nanotechnology and self-assembly, have further provided a fantastic toolbox to sculpt the topology of glycoobjects and, eventually, incorporate refined functional properties. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] Collectively, this vast work has contributed to settle the assumption that presenting a given glycotope in multiple copies on a suitable scaffold is a safe and efficacious way to target a complementary lectin, preserving or even enhancing binding selectivity.…”

Section: Introductionmentioning

confidence: 99%

Carbohydrate supramolecular chemistry: beyond the multivalent effect

2020

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It has been amply constated that sugar ligand multivalency increases lectin-binding avidities dramatically, thereby modulating the capacity of carbohydrates to participate in supramolecular recognition processes involving transfer of biological information. The importance of this concept, the multivalent or glycoside cluster effect, in cell biology in general and in the glycosciences in particular is reflected in the ever-growing number of papers in the field. An impressive range of glycoarchitectures has been conceived to imitate the glycan coating of cells (the glycocalyx) in order to target complementary lectin receptors. However, these models rarely address the heterogeneity and the fluidity of the densely glycosylated cell membrane. They also disregard the impact that high-density nanosized arrangements could have in their interactions with the whole spectrum of carbohydrate-interacting proteins, among which glycosidases are notable representatives. For many years it has been tacitly assumed that:(i) efficient recognition by lectins generally requires high densities of the putative primary ligand and (ii) the mechanisms governing binding of a carbohydrate motif by a lectin or a glycosidase are totally disparate.Notwithstanding, an increasing amount of evidence seriously questions this paradigm. First, it was shown that secondary ''innocent'' ligands can play important roles in the recognition of heteroglycocluster constructs by lectins through synergistic or antagonistic contributions, a phenomenon termed the heterocluster effect. Second, the existence of multivalent effects in the inhibition of certain glycosidases by glycomimetic-and, even more disturbing, glyco-coated architectures (multivalent enzyme inhibition) was demonstrated. These observations call for a generalized multivalent effect governing the supramolecular chemistry of carbohydrate or glycomimetic structures in a biological context, with (hetero)multivalency acting as a multimodal switcher to drive the encoded information through different pathways. In this Feature Article we review the advancements made in the last few years in our understanding of the mechanisms underpinning the generalized multivalent effect, with an emphasis on the potential risks and opportunities derived from (hetero)multivalency-elicited promiscuity.

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“…A variety of chemical modifications aimed to enhance, modulate, or control the properties of HA have been described in literature . Among the possible chemical modifications, cross‐linking and conjugation are the most widely used . The conjugation entails that a compound is grafted onto one HA chain by a single bond only, whereas for cross‐linking, different HA chains are linked together by two bonds or more.…”

Section: Introductionmentioning

confidence: 99%

“…22,23 Among the possible chemical modifications, cross-linking and conjugation are the most widely used. 24 The conjugation entails that a compound is grafted onto one HA chain by a single bond only, whereas for cross-linking, different HA chains are linked together by two bonds or more. Chemical modification of HA can be performed on two available functional sites of HA: the carboxylic acid (-COOH) and hydroxyl groups (-OH) from the backbone chain.…”

Section: Introductionmentioning

confidence: 99%

Bioactive composites based on double network approach with tailored mechanical, physico‐chemical, and biological features

D’Amora

Ronca

Raucci

et al. 2018

J Biomedical Materials Res

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Hyaluronic acid (HA)-based hydrogels are one of the most promising naturally derived biomaterials for tissue engineering applications, as they can play an important role in many key cellular processes. In this study, HA was chemically functionalized with photo-cross-linkable motifs by reacting with methacrylic anhydride (MA) to obtain methacrylated hyaluronic acid (MeHA). A range of MA/HA molar ratios was used to obtain different degrees of substitution (DS) ranging from 3.5% to 74.5%, as showed by nuclear magnetic resonance and attenuated total reflection spectroscopy. By fine tuning the DS, the chemical reaction parameters, and the polymer concentration, it was demonstrated the possibility to tailor their mechanical features. Double network (DN) hydrogels were prepared through the synergic use of MeHA and polyethylene glycole diacrylate (PEGDA). To improve the biological properties of DN hydrogels, bioactive solid signals such as hydroxyapatite nanoparticles (HAp) prepared by sol-gel approach were used in combination with DN hydrogels to obtain an advanced composite material with dual function in terms of mechanical and biological support for soft/hard tissue formation. The results highlighted that composite-DN hydrogels showed a 10-time increase of the storage modulus, if compared to neat MeHA, and an early alkaline phosphatase expression from human mesenchymal stem cells in basal medium. This work can be considered a first systematic approach for the designing of photo-cross-linkable hydrogels, based on a combination of natural/synthetic polymers and HAp, that could be applied in three-dimensional additive manufacturing techniques such as stereolithography. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3079-3089, 2018.

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Application of hyaluronic acid as carriers in drug delivery

Cited by 352 publications

References 49 publications

Extracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering

Extracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering

Carbohydrate supramolecular chemistry: beyond the multivalent effect

Bioactive composites based on double network approach with tailored mechanical, physico‐chemical, and biological features

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