Application of hyaluronic acid/sodium alginate-based microparticles to prevent tissue adhesion in a rabbit model

Back, Ja Hoon; Cho, Wan Jin; Kim, Jun Ho; Park, Il Kyu; Kwon, Sung Won

doi:10.1007/s00595-015-1186-3

Cited by 22 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This high-density polymer shows high viscosity, viscoelasticity, and water-retaining capacity, and could therefore function as a lubricant 18. Additionally, hyaluronic acid is biocompatible, biodegradable (completely degrades within 5 days), and nontoxic, which enhances its popularity as a barrier agent 18,21. In earlier studies, hyaluronic acid was not found to reduce adhesion formation or reformation 28,29.…”

Section: Discussionmentioning

confidence: 98%

“…Therefore, numerous studies are now focused on nonpharmacological agents to prevent adhesions. Nonpharmacological anti-adhesive agents are available in many forms, including liquid, membrane, and textile embodiments, and they mainly provide a physical barrier between adjacent peritoneal surfaces and organs, thus reducing adhesion formation/reformation in clinical use 21. ORC and hyaluronic acid are frequently used anti-adhesive agents in the clinic.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

Zhang

Liu

Yang

et al. 2016

DDDT

View full text Add to dashboard Cite

Postsurgical adhesion formation is the most common complication in abdominal and pelvic surgery. Adhesiolysis is the most commonly applied treatment for adhesion formation but is often followed by adhesion reformation. Therefore, an efficient strategy should be adopted to solve these problems. This study aimed to explore whether hyaluronic acid and oxidized regenerated cellulose (ORC) could prevent adhesion formation and reformation. Thirty female Sprague Dawley rats were randomly divided into three groups (n=10 each) and subjected to different treatments during the first and second surgery. The control group was treated with isotonic sodium chloride, the ORC group was treated with ORC (1.5×1 cm), and the medical sodium hyaluronate (MSH) group was treated with 1% MSH (0.5 mL). At 2 weeks after the first surgery, adhesion scores in the MSH group (1.90±0.99) and the ORC group (1.40±0.97) were significantly lower than those in the control group (3.00±0.82) (P=0.005). Similarly, 2 weeks after the second surgery, adhesion scores in the MSH group (2.00±0.82) and the ORC group (1.50±1.27) were significantly lower than those in the control group (3.50±0.53) (P=0.001). In addition, body weights in the MSH group and the ORC group did not change significantly, whereas the control group showed a consistent decrease in body weight during the experiment. Histological examination revealed that inflammatory infiltration was involved in both adhesion formation and reformation. In conclusion, hyaluronic acid and ORC were both efficient in reducing adhesion formation and reformation in the rat model.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

Zhang

Liu

Yang

et al. 2016

DDDT

View full text Add to dashboard Cite

show abstract

“…It can be inferred that the application of the hyaluronic acid gel is better than an IUD or balloon at improving the pregnancy rate after IUA separation. It was also demonstrated that hyaluronic acid can regulate inflammatory factors, promote the normal epithelialization and regeneration of wound tissues, effectively isolate adjacent healing tissues and prevent the formation of adhesions (30).…”

Section: Discussionmentioning

confidence: 99%

Meta‑analysis on the use of hyaluronic acid gel to prevent intrauterine adhesion after intrauterine operations

Zheng¹,

Xin

He³

et al. 2020

Exp Ther Med

View full text Add to dashboard Cite

Intrauterine adhesion (IUA) is a severe complication that occurs following abortion, and hyaluronic acid gel has been used to prevent IUA following intrauterine operation. The present study aimed to systematically evaluate the efficacy of hyaluronic acid gel in preventing IUA following intrauterine operation. In the current study, a literature search was performed using PubMed, Cochrane Library and EMbase databases for randomized controlled clinical trials that used hyaluronic acid gel as an adjuvant therapy following intrauterine operation. The terms 'hyaluronic acid', 'intrauterine adhesions', 'Asherman's syndrome', 'IUA', 'dilatation and curettage', 'abortion' and 'hysteroscopic' were used to search for articles published online before July 31, 2018. RevMan 5.3 software was used to analyze the indicators of uterine cavity adhesion formation and pregnancy rates following intrauterine operation. A total of seven randomized controlled clinical studies were included, consisting of 952 patients who underwent intrauterine operation. The meta-analysis indicated that the use of hyaluronic acid gel reduced the incidence of IUA [relative risk (RR)=0.42; 95% confidence interval (CI)=0.30-0.57; P<0.001] and the score for IUA after an intrauterine operation (mean difference=-1.29; 95%=-1.73 to-0.84; P<0.001). A subgroup analysis revealed that the preventive effect of hyaluronic acid gel on IUA was not affected by the type of intrauterine operation, namely abortion (RR=0.40; 95% CI=0.26-0.62; P<0.001) and hysteroscopy (RR=0.44; 95% CI=0.28-0.68; P<0.001). The preventive effect of hyaluronic acid gel on IUA was also not affected by primary disorders/diseases including the following: Abortion (RR=0.48; 95% CI=0.29-0.78; P=0.003); IUA (RR=0.38; 95% CI=0.21-0.67; P<0.001) and submucosal myoma of the uterus, endometrial polyps or mediastinum uterus (RR=0.40; 95% CI=0.18-0.90; P=0.03). Hyaluronic acid gel improved pregnancy rates after intrauterine operations (RR=1.94; 95% CI=1.46-2.60; P<0.001). In conclusion, hyaluronic acid gel was indicated to significantly reduce the incidence of IUA following intrauterine operation, regardless of the type of intrauterine operation or the presence of primary diseases. Treatment with hyaluronic acid gel was also revealed to increase pregnancy rates following intrauterine operation.

show abstract

“…13,14 In addition to wound healing, investigators have also evaluated alginate’s effect on fibrosis. Back et al 15 showed that alginate-impregnated dressing caused significantly less postoperative adhesion and fibrosis after experimental laparotomy in the rabbit model. Alginate-coated silicone sheeting has been used to deliver dexamethasone to the middle ear mucosa of guinea pigs, which showed favorable decreases in fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Alginate Ototoxicity in the Mouse Model

Alvi

Nelson-Brantley

Staecker

2018

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

Objective To determine whether alginate exposure to the round window of the mouse causes any measurable ototoxicity. Study Design Prospective animal study. Setting Basic science laboratory affiliated with a tertiary care university medical center. Subjects and Methods After Institutional Animal Care and Use Committee approval, 5 adult mice were obtained and underwent bullostomy and round window niche application of alginate. Auditory brainstem response (ABR) tests were completed at baseline prior to the procedure and also 5, 14, and 30 days postprocedure. Results were compared. At termination of procedure, the mice were sacrificed with harvest of the cochleae, which were viewed under histologic section. Results There were no significant increases in ABR thresholds in any of the test animals at all test periods after alginate exposure compared to baseline. There were also no observable behavioral changes after the procedure to indicate vestibular dysfunction. Cochlear sectioning revealed no evidence of histologic damage. Conclusion Exposure of alginate to the round window does not cause any obvious ototoxicity in the mouse model. Further clinical trials will be needed to elucidate the effect of alginate in the human middle ear.

show abstract

Application of hyaluronic acid/sodium alginate-based microparticles to prevent tissue adhesion in a rabbit model

Abstract: MP shows potential as an effective novel type of resorbable biomaterial to reduce postoperative adhesion. The easy placement and handling of this material make the MP powder attractive as a tissue adhesion barrier.

Cited by 22 publications

References 21 publications

Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

Meta‑analysis on the use of hyaluronic acid gel to prevent intrauterine adhesion after intrauterine operations

Alginate Ototoxicity in the Mouse Model

Contact Info

Product

Resources

About