Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

Abstract

Postsurgical adhesion formation is the most common complication in abdominal and pelvic surgery. Adhesiolysis is the most commonly applied treatment for adhesion formation but is often followed by adhesion reformation. Therefore, an efficient strategy should be adopted to solve these problems. This study aimed to explore whether hyaluronic acid and oxidized regenerated cellulose (ORC) could prevent adhesion formation and reformation. Thirty female Sprague Dawley rats were randomly divided into three groups (n=10 each) and subjected to different treatments during the first and second surgery. The control group was treated with isotonic sodium chloride, the ORC group was treated with ORC (1.5×1 cm), and the medical sodium hyaluronate (MSH) group was treated with 1% MSH (0.5 mL). At 2 weeks after the first surgery, adhesion scores in the MSH group (1.90±0.99) and the ORC group (1.40±0.97) were significantly lower than those in the control group (3.00±0.82) (P=0.005). Similarly, 2 weeks after the second surgery, adhesion scores in the MSH group (2.00±0.82) and the ORC group (1.50±1.27) were significantly lower than those in the control group (3.50±0.53) (P=0.001). In addition, body weights in the MSH group and the ORC group did not change significantly, whereas the control group showed a consistent decrease in body weight during the experiment. Histological examination revealed that inflammatory infiltration was involved in both adhesion formation and reformation. In conclusion, hyaluronic acid and ORC were both efficient in reducing adhesion formation and reformation in the rat model.

Scarless Completion Thyroidectomy After Initial Transoral Approach for Differentiated Thyroid Cancer: How and When to Start?

“…We speculate that the surgical plane of transoral approach would disappear because the fibrous adhesions that occur in surgeries completed beyond 14 days eliminate this approach of a subplatysmal flap for re-TOETVA. 16 Consequently, re-TCA or TAA were adopted for CT beyond the interval of 14 days after initial TOETVA.…”

Hyaluronic acid in gynecology and obstetrics

“…These, in turn, can lead to uterine rupture or postpartum hemorrhage, increasing the risk of pregnancy-related morbidity and mortality [4]. Studies on animal models, both in rats and pigs, suggest, that hyaluronic acid may reduce the incidence of postoperative adhesions [5,6,7,8]. Hence, more and more studies are involving patients with gynecological diseases.…”

Some features of the pathogenetic mechanisms of the development of acute adhesive small bowel obstruction

“…Результаты многочисленных экспериментальных и клинических исследований свидетельствуют о том, что в патогенезе стойкого пареза тонкой кишки особую роль играют нарушения мезентеральной гемодинамики в брыжейке и кишечной стенке [9,10,11,12]. Также учёные полагают, что одним из патогенетических аспектов развития длительного пареза тонкого кишечника в раннем послеоперационном периоде является нарушение обмена серотонина [13,14,15], однако количественное и качественное снижение ЕС-клеток тонкой кишки, продуцирующих серотонин у больных с ОСТКН, остаётся не до конца изученной проблемой.…”