Application of Hydroxytyrosol in the Functional Foods Field: From Ingredient to Dietary Supplements

Silva, Andreia F. R.; Resende, Daniela; Monteiro, Mariana; Coimbra, Manuel A.; Cardoso, Susana M.

doi:10.3390/antiox9121246

Cited by 27 publications

(20 citation statements)

References 107 publications

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“…Secoiridoids include several bioactive compounds found expressed in all species of Oleaceae plants. The composition of bioactive molecules in the leaves depends on plant variety and season harvesting [1][2][3][4][5][6]. In the leaves, oleuropein is the most abundant secoiridoid, having welldocumented health effects.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, OWW is enriched with hydroxytyrosol (HT), which is considered a potent antioxidant compound. In this respect, HT-enriched extracts are marketed as food supplements and patented for their organoleptic and healthy properties [4]. The beneficial effects of olive oil byproducts are mainly due to their antioxidant and antiinflammatory potential.…”

Section: Introductionmentioning

confidence: 99%

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Health benefits of olive oil and by-products and possible innovative applications for industrial processes

Centrone

Ranieri

Mise

et al. 2021

FFHD

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In the last few years, the production of olive oil has incredibly increased due to its beneficial properties on human health. On the other hand, the amount of waste and by-products derived from the olive oil industry has increased as well, prompting the development of new fields of research aiming to reduce disposal costs and valorize bioactive compounds from the viewpoint of the green economy. Interestingly, olive oil and by-products contain numerous molecules, including phenols, exhibiting pleiotropic effects in both in vitro and in vivo studies. This review aims to describe the more recent studies focusing to identify and describe the potential roles and the new applications of extracts isolated from wastes and by-products or specific compounds, such as hydroxytyrosol (HT) and oleuropein. Extracts or bioactive molecules from olive oil and by-products have been proposed as a food additive, to produce biofuel, for animal feeding, and to create new matrices in bioremediation protocols. Moreover, bio-compounds have been described to have numerous beneficial effects on human health as they reduce the risk of developing certain chronic diseases. Despite the already published studies, more research is necessary to valorize bioactive compounds in olive oil and by-products, as well as their potential use to improve human health and green applications in different industrial processes. Keywords: extra virgin olive oil, by-products, olive leaf extract, bioactive compounds, human health, and industrial application

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Health benefits of olive oil and by-products and possible innovative applications for industrial processes

Centrone

Ranieri

Mise

et al. 2021

FFHD

View full text Add to dashboard Cite

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“…The conviction that “diet is the best medicine” applies to the valuing of food ingredients, especially health-promoting bioactive compounds [ 96 ]. The Mediterranean diet trend is described by a high intake of fruits, vegetables, and fish and a lower intake of meats and full-fat dairy products.…”

Section: Discussionmentioning

confidence: 99%

Hidrox® Counteracts Cyclophosphamide-Induced Male Infertility through NRF2 Pathways in a Mouse Model

et al. 2021

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Background: Every year, men use cyclophosphamide to treat various cancers and autoimmune diseases. On the one hand, this chemotherapy often has the beneficial effect of regressing the tumor, but on the other hand, it leads to infertility due to excessive oxidative stress and apoptosis in the testes caused by its metabolite, acrolein. Methods: The objective of this study was to evaluate the beneficial power of a new compound called Hidrox®, containing 40–50% hydroxytyrosol, in counteracting the damage related to fertility induced by cyclophosphamide. The study was conducted using a single intraperitoneal injection of cyclophosphamide at a dose of 200 mg/kg b.w, in distilled water at 10 mL/kg b.w. The treatment was administered via the oral administration of Hidrox® at a dose of 50 mg/kg. Results: Our study confirms that the use of cyclophosphamide causes a series of sperm and histological alterations strongly connected with oxidative stress, lipid peroxidation, and apoptosis. Conclusion: Our results demonstrate for the first time that Hidrox® protects testes from CYP-induced alterations by the modulation of physiological antioxidant defenses.

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“…Regarding extract combinations with higher bioactivities in our data, the combination of extracts rich in 3,4-dihydroxyphenylglycol (P2), hydroxytyrosol (P3), and oleuropein (P4) resulted in the greatest improvement of the cardioprotective bioactivities in most of the experiments (antioxidant, vasoprotective, and anti-inflammatory properties). 3,4-dihydroxyphenylglycol [38,39], hydroxytyrosol [40,41], and oleuropein [42] have previously shown diverse protective effects in molecular mechanisms related to cardiovascular and other non-communicable disease, and the potential synergistic effect among them may play a role in the most complete protective action. These results agree with those shown by De Roos et al, in which a synergistic effect between hydroxytyrosol and 3,4-dihydroxyphenylglycol was observed in the inhibition of platelet aggregation [43].…”

Section: Discussionmentioning

confidence: 99%

From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities

et al. 2021

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Our aim was to assess the combination of olive tree-related extracts with the most favorable profile of in vitro bioactive properties. We tested the antioxidant (increment of low-density lipoprotein resistance against oxidation), vasoactive (promotion of nitric oxide release and decrease of endothelin-1 production in human umbilical vein endothelial cells), anti-inflammatory (decrease of the endothelial production of vascular cell adhesion molecule-1), and antithrombotic (reduction of the endothelial release of plasminogen activator inhibitor-1) capacities of six phenolic extracts and three triterpenic acid solutions (Ps and Ts, respectively). We tested extracts alone and in combination, at nutritional (Ps: 0.05–0.5 μmol/L; Ts: 0.001–0.1 μmol/L) and nutraceutical doses (Ps: 1–10 μmol/L; Ts: 0.25–10 μmol/L). The combination of Ps rich in 3,4-dihydroxyphenylglycol (76%, P2), hydroxytyrosol (95%, P3), and oleuropein (70%, P4) (final nutritional concentration: 0.15 μmol/L; final nutraceutical concentration: 3 μmol/L) was the best in order to prepare functional products and nutraceuticals with cardioprotective properties, despite the fact that the isolated extract with the greatest in vitro properties was P5 (75% oleocanthal), suggesting a potential synergistic effect among different olive components.

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Application of Hydroxytyrosol in the Functional Foods Field: From Ingredient to Dietary Supplements

Cited by 27 publications

References 107 publications

Health benefits of olive oil and by-products and possible innovative applications for industrial processes

Health benefits of olive oil and by-products and possible innovative applications for industrial processes

Hidrox® Counteracts Cyclophosphamide-Induced Male Infertility through NRF2 Pathways in a Mouse Model

From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities

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