Application of β‐Nitrostyrene in Multicomponent Reactions for the Synthesis of Pyrrole Derivatives

Abstract

β-nitrostyrene is an important and effective starting material for the synthesis of heterocycle compounds such as pyrrole derivatives via multicomponent reactions. β-nitrostyrene in its reactions undergoes Michael addition. Pyrroles derivatives are an important group of heterocycle compounds that have many biological and pharmacological activities and are exist in the structure many of natural products. Usually, synthesis of pyrrole derivatives by β-nitrostyrene performed through multicomponent reactions. In this review, synthesis of pyrroles derivatives by β-nitrostyrene through multicomponent reactions is discussed.

Synthesis of Highly Substituted 3-Acylpyrroles by a Four-Component Sonogashira Alkynylation–Amine Addition–Nitroalkene Michael Addition–Cyclocondensation

“…Starting from readily accessible enaminones 18 and nitroalkenes, 19 a highly interesting approach to diversly substituted pyrroles can arise. 15a Several methodologies for the generation of 3-acylpyrroles by the reaction of nitroalkenes with enamino carbonyl compounds have been reported in the literature (Scheme 1 ).…”

Developments and applications of α-bromonitrostyrenes in organic syntheses

“…Bromonitroalkenes, especially bromonitrostyrenes are versatile building blocks for the construction of biological and pharmaceutical molecules and optically active compounds, such as dihydrofurans, 1,2 pyrroles, [3][4][5][6] and pyrazoles. [7][8][9] Selected examples of biologically active molecules containing pyrrole, furan, dihydrofuran, or cyclopropane cores are shown in Scheme 1.…”

Recent progress of nanocatalyst in the synthesis of heterocyclic compounds by barbituric acids

“…In biological processes, they have a role in gene and drug delivery, the immobilization of enzymes, and the detection of pathogens and proteins (Figure 1). 11–13 Applying nanocatalysts in synthetic organic chemistry is a valuable strategy because this method provides various merits involving high catalytic activity, a greener approach, a short period of reaction, excellent yields, catalyst reusability, high substrate tolerance, and scalability 14 . Design and development of new and pivotal nanocatalysts with recyclability and high selectivity is a critical point, and also greener and eco‐friendly methods for producing them are essential and must be developed.…”