Application of Ligilactobacillus salivarius CECT5713 to Achieve Term Pregnancies in Women with Repetitive Abortion or Infertility of Unknown Origin by Microbiological and Immunological Modulation of the Vaginal Ecosystem

Fernández, Leónides; Castro, Irma; Arroyo, Rebeca; Alba, Claudio; Beltrán, David; Rodríguez, Juan M.

doi:10.3390/nu13010162

Cited by 17 publications

(18 citation statements)

References 135 publications

(184 reference statements)

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“…In another study, Ligilactobacillus salivarius CECT5713 (formerly Lactobacillus salivarius) was administered daily for 6 months to 44 pregnant women either with a history of recurrent miscarriages or infertility with abnormal VMB and vaginal pH at baseline. The intervention resulted in 56% of successful pregnancy rate in these women and those with full-term pregnancy had significant increase in vaginal lactobacilli, decrease in vaginal pH, and Nugent score after intervention, suggesting probiotic's ability to balance VMB and support healthy pregnancy in women with fertility issues (Fernández et al, 2021). Women with unexplained infertility diagnosis and receiving a 4-week probiotic supplementation of L. crispatus LbV 88, L. rhamnosus LbV 96, L. jensenii LbV 116, and L. gasseri LbV 150N had no change in overall VMB diversity or composition when compared with controls (Schenk et al, 2021).…”

Section: Probioticsmentioning

confidence: 89%

Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span

Lehtoranta¹,

Ala-Jaakkola²,

Laitila³

et al. 2022

Front. Microbiol.

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Vaginal microbiota plays a central role in women’s health and reproduction. Vaginal microbiota is dynamic and shaped by hormonal shifts in each stage of a woman’s life from pre-puberty to postmenopause. Current research has mainly focused on vaginal bacterial and fungal members of the community and emphasized their role in disease. However, the impact of balanced vaginal microbiota on health and its interaction with the host is yet poorly understood. High abundance of vaginal lactobacilli is most strongly associated with health, but the concept of health may vary as vaginal dysbiosis may be asymptomatic. Furthermore, there is a lot of variation between ethnic groups in terms of dominating vaginal bacteria. Probiotic lactobacilli could be a safe and natural means to balance and maintain healthy vaginal microbiota. Research evidence is accumulating on their role in supporting women’s health throughout life. This review describes the current literature on vaginal microbiota, the major factors affecting its composition, and how the communities change in different life stages. Furthermore, we focused on reviewing available literature on probiotics and their impact on vaginal microbiota and health.

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Section: Probioticsmentioning

confidence: 89%

Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span

Lehtoranta¹,

Ala-Jaakkola²,

Laitila³

et al. 2022

Front. Microbiol.

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“…In semen, high concentrations of TGF-β1 and TGF-β2 can regulate women’s immune tolerance to sperm, embryo implantation, and subsequent pregnancy. After intercourse, the pH of the vagina will activate TGF-β-involved immune tolerance ( 100 ). Furthermore, existing studies show that TGF-β seems to be a factor controlling the apoptosis and proliferation of endometrial cells during the process of embryo implantation.…”

Section: Tgf-β1 In Pathological Pregnancymentioning

confidence: 99%

Role of Transforming Growth Factor-β1 in Regulating Fetal-Maternal Immune Tolerance in Normal and Pathological Pregnancy

et al. 2021

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Transforming growth factor-β (TGF-β) is composed of three isoforms, TGF-β1, TGF-β2, and TGF-β3. TGF-β1 is a cytokine with multiple biological functions that has been studied extensively. It plays an important role in regulating the differentiation of immune cells and maintaining immune cell functions and immune homeostasis. Pregnancy is a carefully regulated process. Controlled invasion of trophoblasts, precise coordination of immune cells and cytokines, and crosstalk between trophoblasts and immune cells play vital roles in the establishment and maintenance of normal pregnancy. In this systematic review, we summarize the role of TGF-β1 in regulating fetal-maternal immune tolerance in healthy and pathological pregnancies. During healthy pregnancy, TGF-β1 induces the production of regulatory T cells (Tregs), maintains the immunosuppressive function of Tregs, mediates the balance of M1/M2 macrophages, and regulates the function of NK cells, thus participating in maintaining fetal-maternal immune tolerance. In addition, some studies have shown that TGF-β1 is dysregulated in patients with recurrent spontaneous abortion or preeclampsia. TGF-β1 may play a role in the occurrence and development of these diseases and may be a potential target for the treatment of these diseases.

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“…Microbiological analyses of six batches showed that the fermented product only contained L. salivarius MP101 and contained the appropriate amount of viable probiotic cells considered valid for the assay (≥9 log 10 CFU/container) for five weeks, provided that the probiotic dairy product was stored at refrigeration temperatures. L. salivarius is a species that contains strains with a high probiotic potential, as assessed by in vitro and in vivo assays and clinical trials [ 27 , 28 , 29 , 30 ]. However, very few strains are commercially available because of their short stability at room temperature.…”

Section: Discussionmentioning

confidence: 99%

Administration of Ligilactobacillus salivarius MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact

Mozota

Castro

Gómez‐Torres

et al. 2021

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The elderly population living in nursing homes is particularly vulnerable to COVID-19 although individual susceptibility to SARS-CoV-2 infection may be related to the host microbiota. The objective of this work was to investigate the effect of Ligilactobacillus salivarius MP101 on the functional (Barthel index), cognitive (GDS/FAST), and nutritional (MNA) status as well as on the nasal and fecal inflammatory profiles of elderly residents living in a nursing home that is highly affected by COVID-19. A total of 25 residents participated in the trial, which involved the daily ingestion of a dairy product (L. salivarius MP101: 9.3 log10 CFU per unit) for 4 months. Nasal and fecal samples were analyzed for 37 immune factors at recruitment and at the end of the study. After the trial, no change in the GDS/FAST scores were found but, in contrast, the values for the Barthel index and the MNA score improved significantly. The concentrations of some immune factors changed significantly after the trial, including a decrease in the concentrations of BAFF/TNFSF13B, APRIL/TNFSF13, IL8, IL31, osteopontin, sTNF-R1, and sTNF-R2, and an increase in chitinase 3-like 1, IL19, IL35, and pentraxin 3 was also observed. In conclusion, L. salivarius MP101 seems to be a promising strain for improving or maintaining health in this highly vulnerable population.

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Application of Ligilactobacillus salivarius CECT5713 to Achieve Term Pregnancies in Women with Repetitive Abortion or Infertility of Unknown Origin by Microbiological and Immunological Modulation of the Vaginal Ecosystem

Cited by 17 publications

References 135 publications

Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span

Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span

Role of Transforming Growth Factor-β1 in Regulating Fetal-Maternal Immune Tolerance in Normal and Pathological Pregnancy

Administration of Ligilactobacillus salivarius MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact

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