“…The integrated optimization approach that combines mechanistic-modeling and machine-learning has been applied in various fields for parameter optimization, such as electronic system design [ 24 ], additive manufacture [ 28 ], solid mechanics [ 29 ], fluid flow [ 30 ], precision medicine [ 31 ], and biomedical engineering [ 32 ]. For example, by coupling machine-learning with electric-thermal simulation, the optimal conditions (e.g., airflow, material, and geometry) for 3-D integrated circuits and systems were explored by Park et al [ 24 ]. In that study, a Bayesian optimization-based machine-learning approach was successfully developed to optimize the operation parameters and system designs, including airflow velocity, thermal conductivity of the thermal interface material, thermal conductivity of under-fill material, thermal conductivity of the printed circuit board, and thickness of thermal interface material, to minimize the maximum temperature and temperature gradient.…”