Application of mesenchymal stem cells derived from bone marrow and umbilical cord in human hair multiplication

Yoo, Bo-Young; Shin, Youn-Ho; Yoon, Hee-Hoon; Seo, Young-Kwon; Song, Kye‐Yong; Park, Jung-Keug

doi:10.1016/j.jdermsci.2010.08.017

Cited by 38 publications

(40 citation statements)

References 41 publications

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“…Finally, Yoo et al generated dermal papilla-like tissue (DPLT) from umbilical cord MSCs following exposure to the dermal papilla forming medium. These generated DPLT, in turn, self-aggregated [26]. When transplanted to athymic mice, these DPLT induced new hair follicle formation.…”

Section: Discussionmentioning

confidence: 99%

Generating CK19-Positive Cells with Hair-Like Structures from Wharton's Jelly Mesenchymal Stromal Cells

Aljitawi

Xiao²,

Zhang³

et al. 2013

Stem Cells and Development

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Wharton's jelly mesenchymal stromal cells (WJMSCs) are considered mesenchymal, multipotent, and capable of differentiating into cells of mesodermal origin. Ectodermal differentiation from mesenchymal cells has been recently reported. Herein, we show for the first time that we can generate cytokeratin 19-positive cells and hair-like structures from WJMSCs in vitro using 2 separate methodologies that utilize osteogenic media to induce WJMSCs to undergo osteogenic differentiation. In one method, WJMSCs were seeded on a matrix isolated from Wharton's jelly following decellularization. In the other method, WJMSCs were cultured to form spheroids. Our findings demonstrate that WJMSCs may have the capacity for ectodermal differentiation.

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Section: Discussionmentioning

confidence: 99%

Generating CK19-Positive Cells with Hair-Like Structures from Wharton's Jelly Mesenchymal Stromal Cells

Aljitawi

Xiao²,

Zhang³

et al. 2013

Stem Cells and Development

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“…For this purpose, a reverse transcription polymerase chain reaction (RT-PCR) was conducted on the cultured cells. 18 The products were then analyzed on 2% agarose gels and visualized by ethidium bromide staining.…”

Section: Characterization and Testingmentioning

confidence: 99%

Polycaprolactone–starch blends with corn-based coupling agent: physical properties and in vitro analysis

Nor

Kurniawan

Seo

et al. 2012

Proc Inst Mech Eng H

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In an attempt to improve properties of polycaprolcatone-starch blend, this study uses zein as coupling agent in preparing the blend through a single-step process. Zein, which has affinity to both polar and non-polar groups, is expected to improve miscibility between the blends' constituents and its overall biocompatibility. Mechanical properties of the blend were tested and further characterizations (Fourier transform infrared spectroscopy, thermal properties) were performed to analyze the effect of zein as an addition to the blend's physical properties. The blend's biocompatibility was examined by indirect methods (contact angle and weight gain after immersion in simulated body fluid) and in vitro analysis. No significant effect on the blend's strength and stiffness was caused by adding zein. Hydrophilicity and cell affinity were improved when zein was added. Zein did not perform as a coupling agent that improved miscibility between polycaprolactone and starch, but its addition improved the blend's biocompatibility.

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“…To this end researchers have used, culture-expanded Mesenchymal Stem Cells (MSCs) to produce self-aggregated spheroidal Dermal Papilla Like Tissues (DPLTs) with the aid of a special culture condition in vitro. 3 Hair inducing activity of selfaggregated DPLTs employing MSCs was tested in athymic mice and was found to have the same hair bulb structure inductive ability as natural DPLTs in vitro. 3 As a result, Umbilical cord derived UC-MSCs and Bone marrow derived BM-MSCs may be an applicable and novel cell source for the generation of human hair.…”

Section: Introductionmentioning

confidence: 99%

“…3 Hair inducing activity of selfaggregated DPLTs employing MSCs was tested in athymic mice and was found to have the same hair bulb structure inductive ability as natural DPLTs in vitro. 3 As a result, Umbilical cord derived UC-MSCs and Bone marrow derived BM-MSCs may be an applicable and novel cell source for the generation of human hair. 3 Stem cells have the capacity to self-renew and to give rise to cells of various lineages.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neonatal derived mesenchymal stem cell mesotherapy in androgenetic alopecia: a retrospective observational study and review of literature

et al. 2015

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Background: Androgenetic alopecia has been a stressful condition for the patients and treating dermatologists alike. With the advent of stem cell therapy in various diseases, and lot of controversies and ethical issues related to it, mesenchymal stem cells MSC have passed the acid test successfully, though with many challenges. Since the stem cells in the hair follicle bulge and the dermal papilla play an important role in hair cycle and growth, introducing an external source of neonatal mesenchymal stem cells seems to be a possibility in the treatment of AGA. Aims: To know the benefits and safety of stem cell treatment in patients who underwent mesotherapy with neonatal MSC in order to establish the safety and efficacy in the treatment of AGA.Methods: We collected data of 40 patients treated with mesoinjections of commercially prepared neonatal MSC, with AGA of grade 2 to 7. Before and after photographs, Patient (PtGA) and Physician (PGA) Global assessment scores were used to evaluate the treatment response.Results: We found that 70% of the patients showed a mild response and 25% of them showed a moderate improvement in the hair growth and reduction in hair loss after 4 sittings of monthly duration. One subject showed an improvement of 72%. Patients had 6 month follow up. No major adverse events were observed.Conclusions: Since this is an observational study, large randomized controlled studies, with longer follow ups is recommended to make MSC therapy a novel treatment option for AGA. Keywords: Mesenchymal stem cells, Mesotherapy, Androgenetic alopecia

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Application of mesenchymal stem cells derived from bone marrow and umbilical cord in human hair multiplication

Cited by 38 publications

References 41 publications

Generating CK19-Positive Cells with Hair-Like Structures from Wharton's Jelly Mesenchymal Stromal Cells

Generating CK19-Positive Cells with Hair-Like Structures from Wharton's Jelly Mesenchymal Stromal Cells

Polycaprolactone–starch blends with corn-based coupling agent: physical properties and in vitro analysis

Neonatal derived mesenchymal stem cell mesotherapy in androgenetic alopecia: a retrospective observational study and review of literature

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