“…In the present proteomics study, we analyzed the blood samples of 284 subjects, generating the data resource that allowed us to reveal molecular similarities and differences within the plasma/ serum proteome in different human cancers: colorectal, pancreatic, lung, prostate, and ovarian carcinomas. To date, no current blood proteomics investigation combines multi-cancer comparisons within the same analysis; such studies rely on meta-analyses and can be confounded by variable pre-analytical factors, proteomics techniques, and measurement machines (Amess et al, 2013). To avoid experimental bias by using one universal control group for all comparisons, our study design included, for each cancer type, a matched control from each hospital center.…”