Application of micro<scp>RNA</scp>s in diagnosis and treatment of cardiovascular disease

Wronska, Anetta; Kurkowska‐Jastrzębska, Iwona; Santulli, Gaetano

doi:10.1111/apha.12416

Cited by 148 publications

(135 citation statements)

References 175 publications

(188 reference statements)

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“…miRNAs regulate gene expression by accelerating mRNA degradation or inhibiting translation at the posttranscriptional level by binding the 3'-untranslated region (UTR) of their target mRNAs [4][5][6] . Numerous studies have revealed that some miRNAs play a significant role in atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Altered Plasma MicroRNAs as Novel Biomarkers for Arteriosclerosis Obliterans

Zheng

Liu

et al. 2016

JAT

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Aim: Arteriosclerosis obliterans (ASO) of the lower extremities is a major cause of adult limb loss worldwide. A timely diagnosis in the early stages of the disease determines the clinical outcomes, however lacking of palpable symptoms remains the biggest obstacle. This study aimed to screen a cluster of microRNAs (miRNAs) that can be used as biomarker for the ASO in the earlier stages. Methods: Plasma from 3 patients with ASO and 3 healthy controls were profiled to screen altered miRNAs by microarray, then Real time PCR was further used to confirm the changes in 55 ASO patients and 54 controls.We also analyzed the correlation of miRNAs level with Fontaine stages and the influence of T2DM which is a common complication with ASO on the level of miRNAs.

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Section: Introductionmentioning

confidence: 99%

Altered Plasma MicroRNAs as Novel Biomarkers for Arteriosclerosis Obliterans

Zheng

Liu

et al. 2016

JAT

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“…MicroRNAs (miRs) are small, generally noncoding RNAs, that regulate gene expression via post-transcriptional degradation or translational repression [14]. Unquestionably, miRs are fundamental regulators of numerous biological processes.…”

Section: Coding or Noncoding: Whether “Tis Nobler In The Mind To Suffmentioning

confidence: 99%

microRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent Restenosis

Santulli

2015

Advances in Experimental Medicine and Biology

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Endothelial cells (EC) and vascular smooth muscle cells (VSMC) are the main cell types within the vasculature. We describe here how microRNAs (miRs)—noncoding RNAs that can regulate gene expression via translational repression and/or post-transcriptional degradation—distinctively modulate EC and VSMC function in physiology and disease. In particular, the specific roles of miR-126 and miR-143/145, master regulators of EC and VSMC function, respectively, are deeply explored. We also describe the mechanistic role of miRs in the regulation of the pathophysiology of key cardiovascular processes including angiogenesis, atherosclerosis, and in-stent restenosis post-angioplasty. Drawbacks of currently available therapeutic options are discussed, pointing at the challenges and potential clinical opportunities provided by miR-based treatments.

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“…33 Endothelium-specific inactivation of this enzyme is associated with altered expression of vascular endothelial growth factor (VEGF), eNOS, IL-8, and the angiopoietin cell surface receptors Tie-I and Tie-2, compromising endothelial function. 34 In addition, miRNAs also serve as paracrine ligands of the toll-like receptors, an exosome-mediated activity that is independent of post-transcriptional regulatory function. 35 Several miRNAs have been identified to play an important role in regulating endothelial function in normal as well as pathological conditions (Table 1).…”

Section: Microrna and Their Role In Vascular Homeostasismentioning

confidence: 99%

Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases

Deshpande¹,

Janero²,

Segura‐Ibarra³

et al. 2016

Methodist DeBakey Cardiovascular Journal

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Endothelial dysfunction has been implicated in the pathophysiology of multiple cardiovascular diseases and involves components of both innate and acquired immune mechanisms. Identifying signature patterns and targets associated with endothelial dysfunction can help in the development of novel nanotherapeutic platforms for treatment of vascular diseases. This review discusses nucleic acid-based regulation of endothelial function and the different nucleic acid-based nanotherapeutic approaches designed to target endothelial dysfunction in cardiovascular disorders.

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Application of microRNAs in diagnosis and treatment of cardiovascular disease

Cited by 148 publications

References 175 publications

Altered Plasma MicroRNAs as Novel Biomarkers for Arteriosclerosis Obliterans

Altered Plasma MicroRNAs as Novel Biomarkers for Arteriosclerosis Obliterans

microRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent Restenosis

Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases

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