Application of microneedle patches for drug delivery; doorstep to novel therapies

Abrbekoh, Fateme Nazary; Salimi, Leila; Saghati, Sepideh; Amini, Hassan; Karkan, Sonia Fathi; Moharamzadeh, Keyvan; Sokullu, Emel; Rahbarghazi‬, Reza

doi:10.1177/20417314221085390

Cited by 34 publications

(14 citation statements)

References 190 publications

(363 reference statements)

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“…Various approaches are therefore used, depending on the applied drug [18]. While some methods damage the skin barrier to promote substance penetration (e.g., microneedling, tape stripping, abrasion) [6,7,19], other methods work with changes in the connectivity of the skin layers (e.g., chemical penetration enhancers like dimethyl sulfoxide or Azone) [1].…”

Section: Discussionmentioning

confidence: 99%

Effect of an Oxygen-Based Mechanical Drug Delivery System on Percutaneous Permeation of Various Substances In Vitro

Elksnat

Zscherpe²,

Klein³

et al. 2022

Pharmaceutics

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Transdermal drug administration is an elegant method to overcome various side effects of oral or parenteral drug administration. Nevertheless, due to an effective skin barrier, which is provided by the stratum corneum, transdermal drug delivery is sometimes very slow and ineffective. Thus, the effect of a medical device (DERMADROP TDA) for transdermal penetration of drugs in conjunction with a special vehicle emulsion on percutaneous permeation of several substances (with different physicochemical properties) was investigated in Franz-type diffusion cells with porcine skin over 28 h. This medical device disperses pharmaceutical agents via oxygen flow through an application system, which is used in conjunction with specially developed vehicle substances. Substance permeation of various substances with different physicochemical properties (diclofenac, enrofloxacin, flufenamic acid, indomethacin, and salicylic acid) was examined after application with a pipette and with the medical device. Therefore, acceptor media samples were collected up to 28 h after drug administration. Drug concentration in the acceptor medium was determined via high-performance liquid chromatography. Enhanced permeation was observed for diclofenac, enrofloxacin, flufenamic acid, indomethacin, and salicylic acid after oxygen-based administration. This correlates negatively with the molecular weight. Thus, drug administration can effectively be enhanced by a medical device using oxygen.

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Section: Discussionmentioning

confidence: 99%

Effect of an Oxygen-Based Mechanical Drug Delivery System on Percutaneous Permeation of Various Substances In Vitro

Elksnat

Zscherpe²,

Klein³

et al. 2022

Pharmaceutics

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“…A lower dose is required when the drug is administered using hollow MNs compared to when using an intramuscular injection. Anthrax and rabies vaccine delivery using hollow MNs have been studied [ 3 ]. Ogai et al have developed hollow MNs by using biodegradable PLGA to improve the delivery and efficiency of the vaccine by intradermal route.…”

Section: Applications Of Mnsmentioning

confidence: 99%

“…Although, these developed systems also have some disadvantages, such as poor patient compliance due to the pain in administration and the invasive nature that requires trained medical practitioners. Furthermore, with the advent of polymer science, nanotechnology, and applied engineering, the concept of MNs was introduced in the literature report [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

Kulkarni¹,

Damiri

Rojekar

et al. 2022

Pharmaceutics

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Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and poor biodistribution, can be overcome by MN-based drug delivery. Nanotechnology made significant changes in fabrication techniques for microneedles (MNs) and design shifted from conventional to novel, using various types of natural and synthetic materials and their combinations. Nowadays, MNs technology has gained popularity worldwide in biomedical research and drug delivery technology due to its multifaceted and broad-spectrum applications. This review broadly discusses MN’s types, fabrication methods, composition, characterization, applications, recent advancements, and global intellectual scenarios.

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“…However, injections are less accepted by patients due to the pain, and topical creams show less bioavailability. [ 8 ] Therefore, designing a formulation that both improves patient compliance and promotes drug penetration has become a key strategy for developing the next generation of TDDS. [ 9 ]…”

Section: Introductionmentioning

confidence: 99%

Advances in Intelligent Stimuli‐Responsive Microneedle for Biomedical Applications

Weng

et al. 2023

Macromolecular Bioscience

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Microneedles (MNs) are a new type of drug delivery method that can be regarded as an alternative to traditional transdermal drug delivery systems. Recently, MNs have attracted widespread attention for their advantages of effectiveness, safety, and painlessness. However, the functionality of traditional MNs is too monotonous and limits their application. To improve the efficiency of disease treatment and diagnosis by combining the advantages of MNs, the concept of intelligent stimulus‐responsive MNs is proposed. Intelligent stimuli‐responsive MNs can exhibit unique biomedical functions according to the internal and external environment changes. This review discusses the classification and principles of intelligent stimuli‐responsive MNs, such as magnet, temperature, light, electricity, reactive oxygen species, pH, glucose, and protein. This review also highlights examples of intelligent stimuli‐responsive MNs for biomedical applications, such as on‐demand drug delivery, tissue repair, bioimaging, detection and monitoring, and photothermal therapy. These intelligent stimuli‐responsive MNs offer the advantages of high biocompatibility, targeted therapy, selective detection, and precision treatment. Finally, the prospects and challenges for the application of intelligent stimuli‐responsive MNs are discussed.

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Application of microneedle patches for drug delivery; doorstep to novel therapies

Cited by 34 publications

References 190 publications

Effect of an Oxygen-Based Mechanical Drug Delivery System on Percutaneous Permeation of Various Substances In Vitro

Effect of an Oxygen-Based Mechanical Drug Delivery System on Percutaneous Permeation of Various Substances In Vitro

Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

Advances in Intelligent Stimuli‐Responsive Microneedle for Biomedical Applications

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