Application of mineral support on cephamycin C production in culture using soybean oil as the sole carbon source

Mitsuru, Ichida; Park, Yong Soo; Kosakai, Yuko; Okabe, Mitsuyasu

doi:10.1002/(sici)1097-0290(19970120)53:2<207::aid-bit11>3.0.co;2-h

Cited by 12 publications

(2 citation statements)

References 13 publications

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“…This difference again could be due to the decreased oil droplet size and increased surface area of oil available to the microorganism. A similar increased oil consumption when using various oil emulsions has been reported (Mitsuru et al 1997). However, the residual oil concentration profile was always significantly higher for the PIT-RSO process.…”

Section: Resultsmentioning

confidence: 99%

The Use of Phase Inversion Temperature (PIT) Microemulsion Technology to Enhance Oil Utilisation during Streptomyces rimosus Fed-batch Fermentations to Produce Oxytetracycline

Papapanagiotou

Quinn

Molitor³

et al. 2005

Biotechnol Lett

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The use of a rapeseed oil emulsion feed, produced by a phase inversion temperature (PIT) process, produced more biomass, gave a 3-fold increase in oil utilisation and a higher oxytetracycline titre but a higher residual oil concentration when compared to a conventional fed-batch Streptomyces rimosus process fed with crude rapeseed oil. Importantly, microbial utilisation of the surfactant was confirmed for the first time.

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Section: Resultsmentioning

confidence: 99%

The Use of Phase Inversion Temperature (PIT) Microemulsion Technology to Enhance Oil Utilisation during Streptomyces rimosus Fed-batch Fermentations to Produce Oxytetracycline

Papapanagiotou

Quinn

Molitor³

et al. 2005

Biotechnol Lett

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“…The GC analysis of fatty acids and glycerides showed no fatty acids in the fermentation broth, although their accumulation at the interface could inhibit lipase synthesis. Mitsuru et al (1997) used a mineral support to increase the oil-water interfacial surface area and reduced their residual oil levels when using soybean oil as the sole carbon source in production of cephamycin C. The disadvantage of using the mineral support was the increase in viscosity, rendering this inapplicable at the industrial scale. Chartrain et al (1991) reported that lypolytic activity was produced late during the growth phase only when the glucose concentration had fallen below 10 g/L and the rate of triglyceride consumption in efrotomycin fermentation was directly related to the extracellular lipolytic activity.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Rapeseed Oil Uptake on the Production of Erythromycin and Triketide Lactone by Saccharopolyspora erythraea

Mirjalili

Zormpaidis

Leadlay

et al. 1999

Biotechnology Progress

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Saccharopolyspora erythraea was grown in an oil-based process medium at two different laboratory scales. The initial concentration of rapeseed oil in the medium was shown not to affect the growth, while addition of oil significantly increased erythromycin A production. Increasing the agitation speed at the 2 L scale increased the growth of the culture and the production of erythromycin A but had little effect on the level of oil remaining in the fermentation. Maximum oil utilization of 50% (w/w) was obtained in both 2 and 7 L cultures. Gas chromatography analysis of the process medium showed that there was no accumulation of fatty acids and glycerides during the fermentations. The specific oil utilization by the recombinant strain of S. erythraea was significantly lower compared to the wild-type strain grown at the same scale and initial oil concentration; the recombinant strain also produced lower concentrations of the novel polyketide, triketide lactone.

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Enhancement ofL(+)-lactic acid production using mycelial flocs ofRhizopus oryzae

Kosakai

Park

Okabe

1997

Biotechnol. Bioeng.

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Application of mineral support on cephamycin C production in culture using soybean oil as the sole carbon source

Cited by 12 publications

References 13 publications

The Use of Phase Inversion Temperature (PIT) Microemulsion Technology to Enhance Oil Utilisation during Streptomyces rimosus Fed-batch Fermentations to Produce Oxytetracycline

The Use of Phase Inversion Temperature (PIT) Microemulsion Technology to Enhance Oil Utilisation during Streptomyces rimosus Fed-batch Fermentations to Produce Oxytetracycline

The Effect of Rapeseed Oil Uptake on the Production of Erythromycin and Triketide Lactone by Saccharopolyspora erythraea

Enhancement ofL(+)-lactic acid production using mycelial flocs ofRhizopus oryzae

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