2023
DOI: 10.3389/fcimb.2023.1200157
|View full text |Cite
|
Sign up to set email alerts
|

Application of mNGS in the study of pulmonary microbiome in pneumoconiosis complicated with pulmonary infection patients and exploration of potential biomarkers

Abstract: BackgroundPneumoconiosis patients have a high prevalence of pulmonary infections, which can complicate diagnosis and treatment. And there is no comprehensive study of the microbiome of patients with pneumoconiosis. The application of metagenomic next-generation sequencing (mNGS) fills the gap to some extent by analyzing the lung microbiota of pneumoconiosis population while achieving accurate diagnosis.MethodsWe retrospectively analyzed 44 patients with suspected pneumoconiosis complicated with pulmonary infec… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(2 citation statements)
references
References 64 publications
0
2
0
Order By: Relevance
“…utilize mNGS to uncover the relationship between lung microbiota and lung diseases in patients with pneumoconiosis and pulmonary infection, implying that lung microbiota could be biomarkers in lung diseases. 15 CRP and PCT could exclude the infection probabilities in critical ill patients but the predictive performance was vulnerable to the impact of antibiotic utility. 30 Compared to CRP or PCT, microbiota would serve as better biomarkers for assessing therapeutic efficacy and monitoring disease progression in lung diseases, as they are less influenced by prior antibiotic exposure.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…utilize mNGS to uncover the relationship between lung microbiota and lung diseases in patients with pneumoconiosis and pulmonary infection, implying that lung microbiota could be biomarkers in lung diseases. 15 CRP and PCT could exclude the infection probabilities in critical ill patients but the predictive performance was vulnerable to the impact of antibiotic utility. 30 Compared to CRP or PCT, microbiota would serve as better biomarkers for assessing therapeutic efficacy and monitoring disease progression in lung diseases, as they are less influenced by prior antibiotic exposure.…”
Section: Discussionmentioning
confidence: 99%
“…Medical modification could be dependent on these results. 14 Moreover, compared to 16S rRNA, mNGS furnishes a broader spectrum of information about the background microbiota, 15 which may be associated with the manifestations of the disease.…”
Section: Introductionmentioning
confidence: 99%