Application of molecular SERS nanosensors: where we stand and where we are headed towards?

Jahn, Martin; Mühlig, Anna; Cialla‐May, Dana

doi:10.1007/s00216-020-02779-2

Cited by 20 publications

(15 citation statements)

References 33 publications

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“…[151][152][153][154] Although Raman is a label-free technique, it can benefit from the use of specific markers, as DNPH in the previous example. This is especially relevant for SERS, SERRS, or SRS techniques, [155] where a metallic particle can be used to enhance the Raman signal that is usually very weak (i.e., less than 1 in 10 8 of incident photons undergoes Raman scattering). [149] As an example, specific ratiometric sensors for SRS can be developed for the detection of intracellular pH.…”

Section: Raman Spectroscopymentioning

confidence: 99%

Multichannel Fluorescence Microscopy: Advantages of Going beyond a Single Emission

Rodríguez‐Sevilla

Thompson

Jaque

2022

Advanced NanoBiomed Research

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Fluorescent microscopy has enabled the study of intracellular processes and revealed the most intricate details of the subcellular structure. This has benefitted not only the basic biological science, but also has had an impact in numerous biomedical applications. Basic fluorescent sensing techniques use the change in the absolute emission of a fluorescent sensor. This entails some disadvantages as the signal might be influenced by factors not directly related to the process under study (e.g., fluctuations in the excitation source). To overcome these drawbacks, one can use multiple emissions of a single or various fluorophores. There are numerous examples of multichannel fluorescence microscopy techniques that have given rise to numerous ratiometric methods and multiplexing assays. Herein, how the use of multiple emission channels has impacted fluorescence microscopy in terms of speed, sensitivity, and resolution is reviewed. Using recent examples, how the easy implementation of multichannel detection can overcome current limitations of the main used fluorescence techniques and promote the development of novel microscopy methods is shown.

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Section: Raman Spectroscopymentioning

confidence: 99%

Multichannel Fluorescence Microscopy: Advantages of Going beyond a Single Emission

Rodríguez‐Sevilla

Thompson

Jaque

2022

Advanced NanoBiomed Research

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“…[ 98 ] Currently, most ROS response strategies assemble molecules that chemically react with ROS on the surface of plasma NP, for example, 4‐mercaptophenyl ester (4‐MPBE) for H 2 O 2 detection, [ 91 ] 2‐mercapto‐4‐methoxyphenol (MMP) for HOCl detection, [ 99 ] and 4‐mercapto‐phenyl borate pincinol ester (MBAPE) for peroxy nitrate detection. [ 100 ]…”

Section: Tumor Metabolite‐responsive Sers Probesmentioning

confidence: 99%

Emergence of Responsive Surface‐Enhanced Raman Scattering Probes for Imaging Tumor‐Associated Metabolites

Yin

Jin

Duan

et al. 2022

Adv Healthcare Materials

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As a core hallmark of cancer, metabolic reprogramming alters the metabolic networks of cancer cells to meet their insatiable appetite for energy and nutrient. Tumor-associated metabolites, the products of metabolic reprogramming, are valuable in evaluating tumor occurrence and progress timely and accurately because their concentration variations usually happen earlier than the aberrances demonstrated in tissue structure and function. As an optical spectroscopic technique, surface-enhanced Raman scattering (SERS) offers advantages in imaging tumor-associated metabolites, including ultrahigh sensitivity, high specificity, multiplexing capacity, and uncompromised signal intensity. This review first highlights recent advances in the development of stimuli-responsive SERS probes. Then the mechanisms leading to the responsive SERS signal triggered by tumor metabolites are summarized. Furthermore, biomedical applications of these responsive SERS probes, such as the image-guided tumor surgery and liquid biopsy examination for tumor molecular typing, are summarized. Finally, the challenges and prospects of the responsive SERS probes for clinical translation are also discussed.

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“…Thus, it is essential to provide a diagnostic tool for monitoring these species for maintaining the quality of healthy life. In the last few decades, the analysis of samples was mainly dependent on sophisticated analytical tools such as high‐performance liquid chromatography (HPLC), [12,13] gas chromatography (GC), [14,15] liquid chromatography (LC), mass spectrometry (MS), [16,17] colorimetric assays, [18] and Raman spectroscopy [19] . Developing fluorescence‐based chemical sensors/probes offer an alternative and simple analytical platform by providing economic viability.…”

Section: Introductionmentioning

confidence: 99%

“…In the last few decades, the analysis of samples was mainly dependent on sophisticated analytical tools such as highperformance liquid chromatography (HPLC), [12,13] gas chromatography (GC), [14,15] liquid chromatography (LC), mass spectrometry (MS), [16,17] colorimetric assays, [18] and Raman spectroscopy. [19] Developing fluorescence-based chemical sensors/probes offer an alternative and simple analytical platform by providing economic viability. The fluorescence technique has been considered a powerful tool for monitoring the living samples due to its non-invasiveness, accessibility, sensitivity, costeffectiveness, and faster analysis.…”

Section: Introductionmentioning

confidence: 99%

Activity‐Based Fluorescent Probes for Sensing and Imaging of Reactive Carbonyl Species (RCSs)

Jana

Baruah

Samanta

2022

Chemistry An Asian Journal

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This review explains various strategies for developing fluorescent probes to detect reactive carbonyl species (RCS). There are several mono and diacarbonyls among 30 varieties of reactive carbonyl species (RCSs) so far discovered, which play pivotal roles in pathological processes such as cancer, neurodegenerative diseases, cardiovascular disease, renal failure, and diabetes mellitus. These RCSs play essential roles in maintaining ion channel regulation, cellular signaling pathways, and metabolisms. Among RCSs, carbon monoxide (CO) is also utilized for its cardioprotective, anti-inflammatory, and anti-apoptotic effects. Fluorescence-based non-invasive optical tools have come out as one of the promising methods for analyzing the concentrations and co-localizations of these small metabolites. There has been a tremendous eruption in developing fluorescent probes for selective detection of specific RCSs within cellular and aqueous environments due to their high sensitivity, high spatial and temporal resolution of fluorescence imaging. Fluorescence-based sensing mechanisms such as intramolecular charge transfer (ICT), photoinduced electron transfer (PeT), excited-state intramolecular proton transfer (ESIPT), and fluorescence resonance energy transfer (FRET) are described. In particular, probes for dicarbonyls such as methylglyoxal (MGO), malondialdehyde (MDA), along with monocarbonyls that include formaldehyde (FA), carbon monoxide (CO) and phosgene are discussed. One of the most exciting advances in this review is the summary of fluorescent probes of dicarbonyl compounds.

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Application of molecular SERS nanosensors: where we stand and where we are headed towards?

Cited by 20 publications

References 33 publications

Multichannel Fluorescence Microscopy: Advantages of Going beyond a Single Emission

Multichannel Fluorescence Microscopy: Advantages of Going beyond a Single Emission

Emergence of Responsive Surface‐Enhanced Raman Scattering Probes for Imaging Tumor‐Associated Metabolites

Activity‐Based Fluorescent Probes for Sensing and Imaging of Reactive Carbonyl Species (RCSs)

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