Application of Molecularly Imprinted Electrochemical Biomimetic Sensors for Detecting Small Molecule Food Contaminants

Shao, Yunling; Duan, Jiaqi; Wang, Miao; Cao, Jing; She, Yongxin; Cao, Zhen; Li, Guangyue; Jin, Fen; Wang, Jing; El‐Aty, A. M. Abd

doi:10.3390/polym15010187

Cited by 16 publications

(6 citation statements)

References 131 publications

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“…The pseudo‐first‐order model implies a linear association involving the logarithm of the difference in solute adsorption between any given time and equilibrium, whereas the pseudo‐second‐order model proposes a connection that incorporates the reciprocal of time and the quantity of solute adsorbed. The fitting of experimental data to these models aids in determining the respective rate constants and predicting the adsorption behavior over time (Andaç et al, 2004; Shao et al, 2022).…”

Section: Methodsmentioning

confidence: 99%

Development of a molecularly imprinted polymer on silanized graphene oxide for the detection of 17‐estradiol in wastewater

Mughal,

Aylaz,

Shaikh

et al. 2024

Water Environment Research

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This research article demonstrates the synthesis, characterization, and electrochemical evaluation of a molecularly imprinted polymer (MIP) on the surface of silanized graphene oxide (silanized GO), which is nanostructured and used to quantify 17‐estradiol (E2) in wastewater. As characterization methods, X‐ray diffraction (XRD), Raman spectroscopy, dynamic scattering light (DSL), scanning electron microscope (SEM), and Fourier transform infrared spectroscopy (FTIR) were utilized to examine the synthesized GO, silanized GO, MIP‐GO composite, and non‐imprinted polymer (NIP)–GO (NIP‐GO) composite. FTIR results confirmed the successful synthesis of GO composites. Raman study confirmed the synthesis of monolayer silanized GO, MIP‐GO composite, and NIP‐GO composite. Surface morphology revealed that after polymerization, the surface of silanized GO sheet‐like morphology is covered with nanoparticles. Adsorption kinetics studies revealed that adsorption follows the pseudo‐second‐order kinetics. Further, we studied the performance of a MIP‐GO‐based sensor by optimizing the effects of pH, scan rate, and incubation period. The linear calibration was achieved between the oxidation peak current and E2 concentration from 0.1 to 0.81 ppm, with a detection limit of 0.037 ppm. The selectivity of the MIP‐GO composite was also checked by using other estrogens, and it was found that E2 is 3.3, 0.5, and 1.4 times more selective than equilin, estriol, and estrone, respectively. The composite was successfully applied to the wastewater samples for the detection of E2, and a good percentage of recoveries were achieved. It suggests that the reported composite can be applied to real samples.Practitioner Points An innovative electrochemical sensor was developed for selective detection of 17‐estradiol through molecularly imprinted polymer fabricated on the surface of silanized GO (MIP‐GO composite). The developed method was comprehensively validated and found to be linear in the range of 0.1 to 0.8 ppm of 17‐estradiol, with 0.037 ppm of limit of detection and 0.1 ppm of limit of quantification, respectively. The developed MIP‐GO‐composite‐based electrochemical sensor was found 3.3, 0.5, and 1.4 times more selective for 17‐estradiol than equiline, estriol, and estrone, respectively. The applicability of a developed sensor was also checked on wastewater samples, and a good percent recovery was obtained.

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Section: Methodsmentioning

confidence: 99%

Development of a molecularly imprinted polymer on silanized graphene oxide for the detection of 17‐estradiol in wastewater

Mughal,

Aylaz,

Shaikh

et al. 2024

Water Environment Research

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show abstract

“…148 MIP-based sensors are used to find types of pollutants in the environment, like chemical residues, organic chemicals, and pharmaceuticals. 149 They do exceptionally well in terms of resilience to adverse environmental conditions. Environmental biosensors are more sensitive, selective, and adaptable when they combine aptamers and biomimetic receptors.…”

Section: Applications Of Aptamers and Biomimetic Receptors In Biosensingmentioning

confidence: 99%

Review—Aptamers and Biomimetic Receptors in Biosensing: Innovations and Applications

Tripathi,

Pandey,

Mishra

et al. 2024

J. Electrochem. Soc.

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The fields of biosensing have been transformed by the discovery of extraordinary molecular recognition components, such as aptamers and biomimetic receptors. Systematic Evolution of Ligands by Exponential Enrichment (SELEX) is a method used to select aptamers, or short sequences of single-stranded DNA (ssDNA) or RNA (ssRNA), based on their unique binding affinity to target molecules. Molecularly imprinted polymers (MIPs) are a type of biomimetic receptor that mimics the selectivity of natural receptors inside a synthetic matrix. They make it possible to identify pathogens, and illness biomarkers with accuracy. Aptamers and biomimetic receptors play crucial roles in various fields including diagnostics, therapeutics, and biosensing. Their high specificity, versatility, and adaptability enable targeted detection, drug delivery, and biomolecule manipulation, thereby contributing to advancements in personalized medicine, biotechnology, and disease diagnosis. Aptamers and biomimetic receptors have been combined with cutting-edge technologies, like nanotechnology and lab-on-a-chip systems, to create biosensors that are quick, portable, and extremely sensitive. These recognition features are anticipated to become more important as technology develops, helping to address global issues, advance biosensing capabilities, and raise people's standard of living everywhere. Recent advancements and innovation on Aptamers and Biomimetic Receptors in Biosensing have been discussed in this review article.

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“…Molecularly imprinted polymers are another affinity material manufactured via chemical processes. Molecularly imprinted polymers can serve in the same way as a biorecognition element and gain specificity to the sensor device [ 54 , 55 , 56 ]. Molecularly imprinted polymers could be mass-produced by the chemical industry, and any structure can be imprinted in theory.…”

Section: Biosensors For the Toxic Biological Warfare Agents Assaymentioning

confidence: 99%

Immunosensors for Assay of Toxic Biological Warfare Agents

Pohanka

2023

Biosensors

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An immunosensor for the assay of toxic biological warfare agents is a biosensor suitable for detecting hazardous substances such as aflatoxin, botulinum toxin, ricin, Shiga toxin, and others. The application of immunosensors is used in outdoor assays, point-of-care tests, as a spare method for more expensive devices, and even in the laboratory as a standard analytical method. Some immunosensors, such as automated flow-through analyzers or lateral flow tests, have been successfully commercialized as tools for toxins assay, but the research is ongoing. New devices are being developed, and the use of advanced materials and assay techniques make immunosensors highly competitive analytical devices in the field of toxic biological warfare agents assay. This review summarizes facts about current applications and new trends of immunosensors regarding recent papers in this area.

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Application of Molecularly Imprinted Electrochemical Biomimetic Sensors for Detecting Small Molecule Food Contaminants

Cited by 16 publications

References 131 publications

Development of a molecularly imprinted polymer on silanized graphene oxide for the detection of 17‐estradiol in wastewater

Development of a molecularly imprinted polymer on silanized graphene oxide for the detection of 17‐estradiol in wastewater

Review—Aptamers and Biomimetic Receptors in Biosensing: Innovations and Applications

Immunosensors for Assay of Toxic Biological Warfare Agents

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