Application of Nanoparticle Materials in Radiation Therapy

Chow, James C. L.

doi:10.1007/978-3-319-48281-1_111-1

Cited by 5 publications

(4 citation statements)

References 55 publications

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“…Energy deposition happened when secondary electrons (yellow dots) were generated along the electron tracks (red). If energy deposition occurred in the DNA (i.e., right-hand side of Figure 2), ionization of the strand of DNA may happen, leading to DNA damage [9,19,36]. The number of histories for the photons interacting with the gold nanoparticle was equal to 300 million in this study, and more photons (~2 billion) were required to achieve a similar uncertainty (2-5% standard deviation) for the simulation model without the gold nanoparticle.…”

Section: Simulation Model and Geomtrymentioning

confidence: 99%

Gold Nanoparticle DNA Damage by Photon Beam in a Magnetic Field: A Monte Carlo Study

Jabeen

Chow

2021

Nanomaterials

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Ever since the emergence of magnetic resonance (MR)-guided radiotherapy, it is important to investigate the impact of the magnetic field on the dose enhancement in deoxyribonucleic acid (DNA), when gold nanoparticles are used as radiosensitizers during radiotherapy. Gold nanoparticle-enhanced radiotherapy is known to enhance the dose deposition in the DNA, resulting in a double-strand break. In this study, the effects of the magnetic field on the dose enhancement factor (DER) for varying gold nanoparticle sizes, photon beam energies and magnetic field strengths and orientations were investigated using Geant4-DNA Monte Carlo simulations. Using a Monte Carlo model including a single gold nanoparticle with a photon beam source and DNA molecule on the left and right, it is demonstrated that as the gold nanoparticle size increased, the DER increased. However, as the photon beam energy decreased, an increase in the DER was detected. When a magnetic field was added to the simulation model, the DER was found to increase by 2.5–5% as different field strengths (0–2 T) and orientations (x-, y- and z-axis) were used for a 100 nm gold nanoparticle using a 50 keV photon beam. The DNA damage reflected by the DER increased slightly with the presence of the magnetic field. However, variations in the magnetic field strength and orientation did not change the DER significantly.

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Section: Simulation Model and Geomtrymentioning

confidence: 99%

Gold Nanoparticle DNA Damage by Photon Beam in a Magnetic Field: A Monte Carlo Study

Jabeen

Chow

2021

Nanomaterials

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“…Several studies are being done on nanoparticles (NPs) because of their size-related  Corresponding author. E-mail address: saifhadimohsen.serag@unicampania.it DOI: https://doi.org/10.55981/aij.2024.1305 characteristics, particularly for use in optics, electronics, and medicine [1].…”

Section: Introduction mentioning

confidence: 99%

“…It results in a higher absorbed dose. Equation (1) shows that photoelectric cross-section depends on Z since the energy is higher than the absorption edges.…”

Section: Introduction mentioning

confidence: 99%

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Investigation of Tissue Components Impacts on Dose Enhancement Factor Using Monte Carlo Code

AL-suhbani,

Baghous,

Serag

et al. 2024

Atom Indo.

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Despite the progress of science in cancer treatments and radiotherapy improvements, there are still several side effects that occur during tumors treatment, particularly on healthy tissues surrounded tumors. Newer treatment methods are being explored lately, one of which is the use of nanoparticles, wherein the tumor is injected with gold nanoparticles. Its aim is to enhance tumor sensitivity to radiation and reduce radiation damage to healthy tissues. Tissue type may play an effective role in enhancing the dose being received under the use of nanoparticles. This study aims to find the effect of different tissue components on dose enhancement factor through MCNP6 and GATE simulations, as well as to accurately compare the simulation results of these two code packages for dose enhancement factors. A 125I brachytherapy source was simulated in phantoms for five tissues or materials (adipose tissue, breast tissue, soft tissue, water, and brain tissue). MCNP6 simulation code was validated by comparing its results with a previous study by Cho et al. Gold nanoparticles were injected as a mixture at a concentration of 7 mg/g into tissues inside a tumor. MCNP6 and GATE simulation results were compared. It was estimated from MCNP simulations that the highest radiation dose enhancement of 2.34 occurs in adipose tissue while lowest dose enhancement of 1.69 is in brain. In comparison, from GATE results, the estimates were that the highest value of dose enhancement factor also occurred in adipose tissue at 2.01, and the lowest value in brain at 1.48. The comparison between two codes suggest that they are compatible with the percentage difference in all tissues being less than 15 %. This study confirms that both MCNP6 and GATE codes could calculate DEF for different tissues under irradiation from a low-energy source.

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An in silico study on the effect of host tissue at brachytherapy dose enhancement by gold nanoparticles

et al. 2021

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Application of Nanoparticle Materials in Radiation Therapy

Cited by 5 publications

References 55 publications

Gold Nanoparticle DNA Damage by Photon Beam in a Magnetic Field: A Monte Carlo Study

Gold Nanoparticle DNA Damage by Photon Beam in a Magnetic Field: A Monte Carlo Study

Investigation of Tissue Components Impacts on Dose Enhancement Factor Using Monte Carlo Code

An in silico study on the effect of host tissue at brachytherapy dose enhancement by gold nanoparticles

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