Climate projections for the Huaihe River Basin, China, for the years 2001-2100 are derived from the ECHAM5/MPI-OM model based on observed precipitation and temperature data covering 1964-2007. Streamflow for the Huaihe River under three emission scenarios (SRES-A2, A1B, B1) from 2010 to 2100 is then projected by applying artificial neural networks (ANN). The results show that annual streamflow will change significantly under the three scenarios from 2010 to 2100. The interannual fluctuations cover a significant increasing streamflow trend under the SRES-A2 scenario (2051-2085). The streamflow trend declines gradually under the SRES-A1Bscenario (2024)(2025)(2026)(2027)(2028)(2029)(2030)(2031)(2032)(2033)(2034)(2035)(2036)(2037), and shows no obvious trend under the SRES-B1 scenario. From 2010 to 2100, the correlation coefficient between the observed and modeled streamflow in SRES-A2 scenario is the best of the three scenarios. Combining SRES-A2 scenario of the ECHAM5 model and ANN might therefore be the best approach for assessing and projecting future water resources in the Huaihe basin and other catchments. Compared to the observed period of streamflows, the projected periodicity of streamflows shows significant changes under different emission scenarios. Under A2 scenario and A1B scenario, the period would delay to about 32-33a and 27-28a, respectively, but under B1 scenario, the period would not change, as it is about 5-6a and the observed period is about 7-8a. All this might affect drought/flood management, water supply and irrigation projects in the Huaihe River basin.