Application of NT‐proBNP and BNP measurements in cardiac care: a more discerning marker for the detection and evaluation of heart failure

Seino, Yoshihiko; Ogawa, Aiko; Yamashita, Teruyo; Fukushima, Masato; Ogata, Kenichi; Fukumoto, Hiroko; Takano, Teruo

doi:10.1016/j.ejheart.2003.12.009

Cited by 185 publications

(124 citation statements)

References 20 publications

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“…The diagnostic threshold gives a sensitivity of 98 %, specificity of 79 % with area under the ROC curve of 0.93. The NT-pro BNP values increased more strikingly in heart failure than BNP, as is shown in other studies [2][3][4][5] . Clear separation between normal and abnormal values of NTproBNP suggests that NT-proBNP is useful and relevant in monitoring cardiovascular diseases.…”

Section: Discussionsupporting

confidence: 68%

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The Relevance of Brain Natriuretic Peptides Investigation in Various Cardiovascular Diseases

Kotaška¹,

Popelová²,

Tiserova³

et al. 2006

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background: Brain natriuretic peptides are relevant markers of heart impairment. Aim: We investigated the relevance of investiging brain natriuretic peptides (NT-proBNP, BNP) in monitoring different types of cardiovascular disease (chronic heart failure due to coronary artery disease, cardiomyopathy, acquired valve disease, congenital heart diseases).Methods: The NT-proBNP assay (Roche) was performed on 280 patients (mean age 49 years; range 20-89 years) and 48 healthy controls (mean age 43 years; range 13-65 years) and BNP assay (Bayer Shionoria) was performed in a subgroup of 42 patients (mean age 50 years; range 20-79 years). Patients were divided into four groups characterized by severity of heart failure according to the New York Heart Association classification.Results: NT-proBNP concentrations differed in patients with cardiovascular diseases from controls (median 371 ng/l versus 41.5 ng/l, p < 0.0001). The cut off value of NT-proBNP determined in 280 patients with cardiovascular diseases was at 130 ng/l (AUC-area under curve = 0.93; sensitivity 98 %; specificity 79 %). Comparison of NT-proBNP and BNP values in patients showed significant correlation (r = 0.93; p < 0.0001). NT-proBNP showed significant differences between groups.Conclusions: Measurement of brain natriuretic peptides is useful and relevant in various types of heart diseases including congenital.

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Section: Discussionsupporting

confidence: 68%

“…Natriuretic peptides BNP and N-terminal-proBNP are well established serum biomarkers for acute and chronic heart failure [1][2][3][4][5] . BNP is released from the atria and ventricles of the heart in response to volume overload, increased filling pressures and myocardial wall stretching.…”

Section: Introductionmentioning

confidence: 99%

The Relevance of Brain Natriuretic Peptides Investigation in Various Cardiovascular Diseases

Kotaška¹,

Popelová²,

Tiserova³

et al. 2006

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…The natriuretic peptides BNP and N-terminal-proB-NP are well established serum biomarkers for acute and chronic heart failure [1][2][3] . The prevalence of heart diseases increases markedly with age 4 and early diagnosis of heart failure is crucial.…”

Section: Introductionmentioning

confidence: 99%

NT-proBNP AND BNP VALUES IN CARDIAC PATIENTS WITH DIFFERENT DEGREE OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION

Kotaška¹,

Popelová²,

Tiserova³

et al. 2006

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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We investigated the performance of brain natriuretic peptides (BNP and NT-proBNP) in detecting various degrees of left ventricular systolic dysfunction. The NT-proBNP assay (Roche) and the BNP assay (Bayer Shionoria) were performed in 46 patients (mean age 50 years; range 20-79 years) with various types of heart disease (chronic heart failure due to coronary artery disease, cardiomyopathy, acquired valve disease, congenital heart diseases) and different impairment of left ventricular systolic dysfunction was assessed by echocardiography. Patients were divided into four groups according to the left ventricular ejection fraction (LVEF) correlated with clinical severity. Significant differences in medians of NT-proBNP and BNP values between all groups were determined (P= 0.0161 for NT-proBNP and P=0.0180 for BNP). For identifying patients with severe systolic dysfunction (LVEF<40%), receiver operating characteristic (ROC) analysis for both BNP and NT-proBNP was performed. The diagnostic performances expressed as areas under the curve were of 0.69 for NT-proBNP (cut off value 367 pg/ml) and 0.60 for BNP (cut off value 172 pg/ml). However, the BNP showed higher sensitivity (85 % vs. 63 %) and a higher positive predictive value (69 % vs 55 %) than the NT-proBNP. The negative predictive values of BNP and NT-proBNP were similar (70 % and 71 % respectively).Brain natriuretic peptides are promising markers for the diagnosis of severe left ventricular systolic dysfunction.

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“…This proves that NT-proBNP is a potent diagnostic aid as a means of identifying patients with systolic or diastolic dysfunction (Seino et al, 2004).…”

Section: Correlation Between Serum Biomarkers and Echocardiographic Pmentioning

confidence: 98%

Prognostic value of N-terminal pro-B-type natriuretic peptide in patients with non-ST-segment elevation acute coronary syndromes

Medjedovic¹

2012

Afr. J. Pharm. Pharmacol.

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The aim of this study was to compare the predictive value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and other frequently used biomarkers, such as creatine kinase (CK), creatine kinase-mB (CK-MB), cardiac troponin T (cTnT) and C-reactive protein (CRP) for systolic and diastolic left ventricular function (SLVF and DLVF), and adverse coronary events in patients with non-ST-segment elevation acute coronary syndrome. The research was carried out within a group of 75 patients. Patients with referent NT-proBNP levels (<14.75 pmol/l) had significantly less compromised SLVF as compared to patients with elevated NT-proBNP levels. Initially determined levels of NT-proBNP showed statistically significant correlations with all parameters of left ventricular function measured on the control examination, while other biomarkers, except creatine kinase, did not. High sensitivity and negative predictive value of NT-proBNP for SLVF (up to 95.1 and 88.9%, respectively) and adverse coronary events (up to 100.0%) was found. These results make us assume that NT-proBNP may be the single best predictor of left ventricular function in patients with non-ST-segment elevation acute coronary syndromes.

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Application of NT‐proBNP and BNP measurements in cardiac care: a more discerning marker for the detection and evaluation of heart failure

Cited by 185 publications

References 20 publications

The Relevance of Brain Natriuretic Peptides Investigation in Various Cardiovascular Diseases

The Relevance of Brain Natriuretic Peptides Investigation in Various Cardiovascular Diseases

NT-proBNP AND BNP VALUES IN CARDIAC PATIENTS WITH DIFFERENT DEGREE OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION

Prognostic value of N-terminal pro-B-type natriuretic peptide in patients with non-ST-segment elevation acute coronary syndromes

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