Application of nuclear magnetic resonance spectroscopy for quantitative analysis of miconazole, metronidazole and sulfamethoxazole in pharmaceutical and urine samples

Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR

“…The proton and carbon chemical shifts were referenced to the internal reference TSP (proton, ı = 0.00 ppm; carbon, ı = 0.00 ppm). All chemical entities extracted from the preparative scale biosynthesis were first analyzed and afterwards quantified by addition of a known concentration maleic acid (20 g) [34]. Data were processed using ACDLabs software, version 11.03.…”

Quantification of acesulfame potassium in processed foods by quantitative 1H NMR

“…In particular, quantification using 1 H NMR (qHNMR) is widely applied in the quantification of medicines [11,12], beverage components [13,14], and natural products in medicinal plant extracts [15][16][17] due to its high sensitivity and the widespread presence of 1 H nuclei in organic molecules [18]. In qHNMR, the content or concentration of the analyte is determined using the ratio between the integral values of a specific signal of the analyte to that of an internal standard (IS).…”

Spectrophotometric methods for the simultaneous determination of binary mixture of metronidazole and diloxanide furoate without prior separation

“…Metronidazole 2-methyl-5-nitroimidazole-1-ethanol [1] was determined individually by short-wave length NIR spectroscopy [2], voltammetry [3][4][5], NMR spectrometry [6], gas chromatography [7] and HPLC methods either alone [8][9][10] or in the presence of its metabolites [11,12] or in the presence of its degradation product [13], in addition to its mixture with other drugs [14,15]. First derivative spectrophotometry was used for the determination of metronidazole in mixture with ciprofloxacin [16].…”