Application of olfactory ensheathing cells in clinical treatment of spinal cord injury: meta-analysis and prospect

Chen, Huijing; Tan, Qijia; Xie, Caijun; Liu, Cong; Chen, Yun; Deng, Yuer; Gan, Yanling; Zhan, Wengang; Zhang, Zhi‐Qiang; Sharma, Arti; Sharma, Hari Shanker

doi:10.26599/jnr.2019.9040008

Cited by 8 publications

(6 citation statements)

References 30 publications

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“…Cell transplantation is an important treatment for patients with intermediate and chronic SCI. [155][156][157][158][159][160][161][162][163][164][165][166][167][168][169][170][171][172][173][174]. However, a few patients experience no effect [175,176].…”

Section: Cell Therapymentioning

confidence: 99%

Clinical guidelines for neurorestorative therapies in spinal cord injury (2021 China version)

Guo¹,

Feng²,

Sun³

et al. 2021

Journal of Neurorestoratology

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Treatment of spinal cord injury (SCI) remains challenging. Considering the rapid developments in neurorestorative therapies for SCI, we have revised and updated the Clinical Therapeutic Guidelines for Neurorestoration in Spinal Cord Injury (2016 Chinese version) of the Chinese Association of Neurorestoratology (Preparatory) and China Committee of International Association of Neurorestoratology. Treatment of SCI is a systematic multimodal process that aims to improve survival and restore neurological function. These guidelines cover real-world comprehensive neurorestorative management of acute, subacute, and chronic SCI and include assessment and diagnosis, pre-hospital first aid, treatment, rehabilitation, and complication management.

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Section: Cell Therapymentioning

confidence: 99%

Clinical guidelines for neurorestorative therapies in spinal cord injury (2021 China version)

Guo¹,

Feng²,

Sun³

et al. 2021

Journal of Neurorestoratology

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“…MSCs can regulate immune response and secrete a variety of immunomodulatory and neurotrophic factors including interleukin-6 (IL-6), NGF, BDNF, GDNF, and the vascular endothelial growth factor (VEGF). MSCs have been widely used in the repair of SCI due to their easy isolation, proliferation, and low immunogenicity [ 77 , 78 , 79 , 80 , 81 ]. White et al used mesenchymal progenitor cells injected via the tail vein of mice cervical SCI models 1 to 10 days after injury and found that those cells were evenly distributed in lungs, and may play as cellular target decoys to the immune system of mice SCI model, and reduce secondary injury to the spinal cord tissue [ 82 ].…”

Section: Stem Cells Overexpressing Neurotrophic Factorsmentioning

confidence: 99%

Sustained delivery of neurotrophic factors to treat spinal cord injury

Muheremu

Liang

et al. 2021

Translational Neuroscience

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Acute spinal cord injury (SCI) is a devastating condition that results in tremendous physical and psychological harm and a series of socioeconomic problems. Although neurons in the spinal cord need neurotrophic factors for their survival and development to reestablish their connections with their original targets, endogenous neurotrophic factors are scarce and the sustainable delivery of exogeneous neurotrophic factors is challenging. The widely studied neurotrophic factors such as brain-derived neurotrophic factor, neurotrophin-3, nerve growth factor, ciliary neurotrophic factor, basic fibroblast growth factor, and glial cell-derived neurotrophic factor have a relatively short cycle that is not sufficient enough for functionally significant neural regeneration after SCI. In the past decades, scholars have tried a variety of cellular and viral vehicles as well as tissue engineering scaffolds to safely and sustainably deliver those necessary neurotrophic factors to the injury site, and achieved satisfactory neural repair and functional recovery on many occasions. Here, we review the neurotrophic factors that have been used in trials to treat SCI, and vehicles that were commonly used for their sustained delivery.

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“…Similarly, SCI is a destructive and traumatic injury that involves primary and secondary injury (Wang and Song, 2019 ; Ma et al, 2020 ). It can lead to loss of sensory, motor, and autonomic nerve function (Chen et al, 2019a ; Reis et al, 2020 ; Wang et al, 2020c ). The regeneration capacity of the CNS is very limited (Ma et al, 2019 ; Radabaugh et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

New Insight of Circular RNAs' Roles in Central Nervous System Post-Traumatic Injury

Zhong

et al. 2021

Front. Neurosci.

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The central nervous system (CNS) post-traumatic injury can cause severe nerve damage with devastating consequences. However, its pathophysiological mechanisms remain vague. There is still an urgent need for more effective treatments. Circular RNAs (circRNAs) are non-coding RNAs that can form covalently closed RNA circles. Through second-generation sequencing technology, microarray analysis, bioinformatics, and other technologies, recent studies have shown that a number of circRNAs are differentially expressed after traumatic brain injury (TBI) or spinal cord injury (SCI). These circRNAs play important roles in the proliferation, inflammation, and apoptosis in CNS post-traumatic injury. In this review, we summarize the expression and functions of circRNAs in CNS in recent studies, as well as the circRNA–miRNA–mRNA interaction networks. The potential clinical value of circRNAs as a therapeutic target is also discussed.

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Application of olfactory ensheathing cells in clinical treatment of spinal cord injury: meta-analysis and prospect

Cited by 8 publications

References 30 publications

Clinical guidelines for neurorestorative therapies in spinal cord injury (2021 China version)

Clinical guidelines for neurorestorative therapies in spinal cord injury (2021 China version)

Sustained delivery of neurotrophic factors to treat spinal cord injury

New Insight of Circular RNAs' Roles in Central Nervous System Post-Traumatic Injury

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