Application of peptide nucleic acid to the direct detection of deoxyribonucleic acid amplified by polymerase chain reaction

Biosensors and biochips: advances in biological and medical diagnostics

“…In the last decade, nucleic acids have received increasing interest as bioreceptors for biosensor and biochip technologies [26][27][28][29][30][31]. The complementarity of adenine : thymine (A : T) and cytosine : guanosine (C : G) pairing in DNA (Fig.…”

Effect of ionic strength on PNA-DNA hybridization on surfaces and in solution

“…30 The latter is becoming increasingly important in application such as microarray technology 31 and SPR biosensors. 32 For example, the detection of point mutations related to genetic diseases was accomplished using SPR technologies and PNAs ͑Ref. 33͒ or modified PNAs.…”

Electrochemical Surface Plasmon Resonance Spectroscopy at Bilayered Silver/Gold Films

“…[3][4][5][6] SPR is attractive owing to several inherent advantages (e.g., labelfree analysis, simplicity, cost-effectiveness, and high sensitivity). [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] The SPR resonance angle variation is dependent on various physicochemical processes occurring at the SPR substrate (a thin metal film or a chemically modified metal surface) and/or the substrate/ solution interface. Thus, when coupled with electrochemistry (EC-SPR), it offers a viable avenue to probe optical and electrochemical properties of adsorbates and a sensitive means to quantify thickness variations of ultrathin films accompanying redox reactions.…”