Connection of the publication with planned research works.The study is a fragment of the research work of the Department of Therapeutic Dentistry of the Poltava State Medical University, «Development of pathogenetic prevention of pathological changes in the oral cavity of people with internal diseases»; state registration number 0121U108263.Introduction.According to WHO (2019), periodontal disease is diagnosed in 65-98% of patients aged 35 to 44. The multifactorial etiopathogenetic model of inflammatory and inflammatory-dystrophic lesions of periodontal tissues explains the complex approach to their treatment, which involves prescribing a significant number of pharmacotherapeutic drugs [1].The source of antimicrobial agents in treating periodontal diseases can be extracted from medicinal plants. Their peculiarity is that their biologically active substances are in a particular ratio, contributing to the optimal effect on the human body. Some constituent components of herbal preparations are similar to physiologically active substances of the body (hormones, vitamins, enzymes, etc.). Due to this, they are more actively involved in the biochemical processes of the human body than synthetic ones. Unlike traditional antibacterial drugs, most antibiotics of plant origin, in addition to antimicrobial action, have a pronounced positive effect on the microorganism [2].The main advantage of herbal remedies is the optimal composition due to the content of various biologically active substances, alkaloids, flavonoids, glycycoumarin, lycocoumarin, etc. [3,4].Among the advantages of plant-based drugs are the absence of adverse reactions, the possibility of longterm use, compatibility with other medications, as well as with each other; it is possible to use it at home, without the presence of special equipment, trust in the part