The antiseptic properties of endodontic materials are used for microbial control in root canals. Decrease in microfloria is known as one of key demands for root canal therapy. The aim of this work is to study the sensitivity of reference strains of microorganisms to citrate buffer and its combination with the antibiotic «Amoxiclav». We used the museum strains of E. coli ATCC 25922, S. aureus ATCC 25923, S. epidermidis ATCC 14990, E. faecalis ATCC 29212, M. lysodeicus ATCC 4698 and C. albicans ATCC10231 to solve this task. The disk-diffusion method for assessing the sensitivity of standard strains of microorganisms was used. We used chlorhexidine digluconate 0.05% as a control. Citrate buffer has high antibacterial activity. The combination of citrate buffer with antibiotic increases the sensitivity of all reference strains. E. coli ATCC 25922 demonstrates a moderate sensitivity to citrate buffer. This combination with an antibiotic increases the antibacterial effect in 2.3 times (p < 0.05). The sensitivity of enterococci increases towards the direction of chlorhexidine – citrate buffer – citrate buffer + «Amoxiclav». When comparing the results obtained using citrate buffer, its combination with antibiotic and chlorhexidine as a control, we should stress on the lower activity of chlorhexidine to strains of transient and normal oral microflora, which are E. coli ATCC 25922 and M. lysodeisticus ATCC 4698. On the contrary, we have revealed more pronounced action of experimental compositions against strains of pathogenic and opportunistic microorganisms, staphylococci, enterococci and yeast-like fungi that points out the advantage of citrate buffer and its combination with antibiotic «Amoxiclav» in terms of their use in the treatment of complicated caries.

Connection of the publication with planned research works.The study is a fragment of the research work of the Department of Therapeutic Dentistry of the Poltava State Medical University, «Development of pathogenetic prevention of pathological changes in the oral cavity of people with internal diseases»; state registration number 0121U108263.Introduction.According to WHO (2019), periodontal disease is diagnosed in 65-98% of patients aged 35 to 44. The multifactorial etiopathogenetic model of inflammatory and inflammatory-dystrophic lesions of periodontal tissues explains the complex approach to their treatment, which involves prescribing a significant number of pharmacotherapeutic drugs [1].The source of antimicrobial agents in treating periodontal diseases can be extracted from medicinal plants. Their peculiarity is that their biologically active substances are in a particular ratio, contributing to the optimal effect on the human body. Some constituent components of herbal preparations are similar to physiologically active substances of the body (hormones, vitamins, enzymes, etc.). Due to this, they are more actively involved in the biochemical processes of the human body than synthetic ones. Unlike traditional antibacterial drugs, most antibiotics of plant origin, in addition to antimicrobial action, have a pronounced positive effect on the microorganism [2].The main advantage of herbal remedies is the optimal composition due to the content of various biologically active substances, alkaloids, flavonoids, glycycoumarin, lycocoumarin, etc. [3,4].Among the advantages of plant-based drugs are the absence of adverse reactions, the possibility of longterm use, compatibility with other medications, as well as with each other; it is possible to use it at home, without the presence of special equipment, trust in the part

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