Application of Platelet-Rich Plasma in Maxillofacial Surgery

Gentile, Pietro; Bottini, Davide J.; Spallone, Diana; Curcio, Beniamino Cristiano; Cervelli, Valerio

doi:10.1097/scs.0b013e3181d878e9

Cited by 65 publications

(53 citation statements)

References 21 publications

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“…(2010) reported their experience on 15 cases, including reconstructive surgery of the jaw, post-extraction alveolar bone regeneration, and oral implantology. The results of their study revealed the efficacy of the PRP treatment in terms of post-operative patients' satisfaction and low-morbidity [63]. Anand et al .…”

Section: Methodsmentioning

confidence: 99%

Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration

et al. 2013

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Platelet-rich plasma (PRP) is a new approach to tissue regeneration and it is becoming a valuable adjunct to promote healing in many procedures in dental and oral surgery, especially in aging patients. PRP derives from the centrifugation of the patient's own blood and it contains growth factors that influence wound healing, thereby playing an important role in tissue repairing mechanisms. The use of PRP in surgical practice could have beneficial outcomes, reducing bleeding and enhancing soft tissue healing and bone regeneration. Studies conducted on humans have yielded promising results regarding the application of PRP to many dental and oral surgical procedures (i.e. tooth extractions, periodontal surgery, implant surgery). The use of PRP has also been proposed in the management of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with the aim of enhancing wound healing and bone maturation. The aims of this narrative review are: i) to describe the different uses of PRP in dental surgery (tooth extractions and periodontal surgery) and oral surgery (soft tissues and bone tissue surgery, implant surgery and BRONJ surgery); and ii) to discuss its efficacy, efficiency and risk/benefit ratio. This review suggests that the use of PRP in the alveolar socket after tooth extractions is certainly capable of improving soft tissue healing and positively influencing bone regeneration but the latter effect seems to decrease a few days after the extraction. PRP has produced better results in periodontal therapy in association with other materials than when it is used alone. Promising results have also been obtained in implant surgery, when PRP was used in isolation as a coating material. The combination of necrotic bone curettage and PRP application seem to be encouraging for the treatment of refractory BRONJ, as it has proven successful outcomes with minimal invasivity. Since PRP is free from potential risks for patients, not difficult to obtain and use, it can be employed as a valid adjunct in many procedures in oral and dental surgery. However, further RCTs are required to support this evidence.

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Section: Methodsmentioning

confidence: 99%

Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration

et al. 2013

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“…Histomorphological observations showed that 54% of patients treated with PRP achieved 100% bone regeneration within 24 weeks, compared with 38% of the control group. [36] This implies that there is acceleration of bone growth with PRP.…”

Section: Discussionmentioning

confidence: 99%

Bone regeneration with plasma-rich-protein following enucleation of traumatic bone cyst

et al. 2013

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Traumatic bone cyst is an uncommon non-epithelium lined cavity and is seen frequently in young individuals. The lesion occurs more commonly in the mandible, involving the posterior region. It is generally asymptomatic and is diagnosed on routine radiographic examination. The cystic cavity is usually empty and there is scanty material for histological examination. Surgical curettage is usually done and recurrence is rare. A case of traumatic bone cyst occurring in the anterior region of mandible in a young boy is presented. Following surgical intervention, plasma-rich-protein was placed in the cystic cavity. The lesion showed progressive resolution and bone regeneration of the cystic cavity within a short period of time.

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“…37, 38, 39 The potential of PRP in modulating soft- and hard-tissue formation and regeneration depends on the levels of released growth factors. 40 For peripheral nerve regeneration, as summarized in Table 2, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52 various known cytokines and growth factors within platelet-rich plasma, including transforming growth factor-β (TGF-β), platelet-derived growth factor, vascular endothelial growth factor, insulin-like growth factor and basic fibroblast growth factor (bFGF), have been discussed as being crucial for cell proliferation and differentiation, stimulation of angiogenesis and scar control in the process of regenerating peripheral nerve structures.…”

Section: Prp Treatment: Preparation and Biological Characteristicsmentioning

confidence: 99%

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

et al. 2017

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Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma (PRP) therapy is a promising treatment for musculoskeletal injuries. Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field. Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms. This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and (pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed.

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Application of Platelet-Rich Plasma in Maxillofacial Surgery

Cited by 65 publications

References 21 publications

Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration

Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration

Bone regeneration with plasma-rich-protein following enucleation of traumatic bone cyst

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

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