Application of Pleurotus ostreatus to efficient removal of selected antidepressants and immunosuppressant

Kózka, Bartosz; Nałęcz‐Jawecki, Grzegorz; Turło, Jadwiga; Giebułtowicz, Joanna

doi:10.1016/j.jenvman.2020.111131

Cited by 15 publications

(12 citation statements)

References 33 publications

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“…Pharmaceuticals, the degradation of which was tested, belonged to various pharmacological and chemical groups. Of all compounds tested, only venlafaxine and citalopram did not completely degrade under the conditions of the experiment, which corresponds to our previous results [33]. Previously, we found that these compounds were the least-efficiently removed among all examined PhACs.…”

Section: Removal Studysupporting

confidence: 90%

“…According to our published paper, the fungus P. ostreatus performs bioconversion of some of the β-lactam antibiotics when using post products of an antibiotic fermentation process as components of its culturing media [32]. Moreover, in the next paper, we confirmed the removal potential of antidepressants and immunosuppressants by P. ostreatus [33]. We have also tested the ability of the species to remove selected pharmaceuticals in culturing media containing wastewater.…”

Section: Introductionmentioning

confidence: 62%

“…We used Kinetex RP-18 column (100 mm × 4.6 mm, particle size 2.6 µm) supplied by Phenomenex (Torrance, CA, USA). A detailed description of the analytical method was described previously [33].…”

Section: Removal Of Pharmaceuticalsmentioning

confidence: 99%

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Optimization of White-Rot Fungi Mycelial Culture Components for Bioremediation of Pharmaceutical-Derived Pollutants

Sośnicka

Kózka

Makarova

et al. 2022

Water

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White-rot fungi can degrade a wide spectrum of environmental pollutants, including pharmaceuticals, which are not efficiently removed from wastewater by conventional methods, e.g., the activated sludge method. However, the treatment of wastewater with the use of fungal cultures (mycoremediation) also has significant limitations: among others, the need to use appropriate, often-expensive culture media. We aimed to screen 18 media ingredients, including seven agrifood byproducts for Armillaria mellea, Phanerochaete chrysosporium and Pleurotus ostreatus in submerged cultures to select the low-cost medium optimal for biomass production and laccase activity. We screened nine mathematic models to describe the relation of fungal growth and the amount of the selected byproduct in media. Finally, we tested the ability of the strain with the highest mycelial growth and enzyme-producing ability in the selected medium to degrade eight drug contaminants. Three media variants composed of byproducts provided both efficient growth and laccase production: corn steep liquor + poplar, dried distillers grains with solubles + poplar and corn steep liquor 50%. Among the investigated growth models, the Han–Levenspiel equation described well the specific growth rate in function of the nominal substrate concentration in one-component media. Pleurotus ostreatus, the fungus with the highest ligninolytic enzyme activity, cultured in medium composed of corn steep liquor, removed six of eight drug contaminants with a removal degree of 20–90% in 48 h. The obtained data on the optimal culture media consisting of insoluble components provide initial data for upscaling the process and designing an appropriate type of bioreactor for the process of removing drug contaminants from water.

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Section: Removal Studysupporting

confidence: 90%

Section: Introductionmentioning

confidence: 62%

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Optimization of White-Rot Fungi Mycelial Culture Components for Bioremediation of Pharmaceutical-Derived Pollutants

Sośnicka

Kózka

Makarova

et al. 2022

Water

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“…Considering molecular weight and chemical structure, Kózka et al [ 87 ] observed three main types of transformations of a series of antidepressants and immunosuppressants carried out by fungal ligninolytic enzymes. The first one is chemical oxidation and occurred for clomipramine, mianserin, sertraline, fluoxetine and citalopram.…”

Section: Enzymatic Biodegradationmentioning

confidence: 99%

Current Challenges for Biological Treatment of Pharmaceutical-Based Contaminants with Oxidoreductase Enzymes: Immobilization Processes, Real Aqueous Matrices and Hybrid Techniques

et al. 2022

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The worldwide access to pharmaceuticals and their continuous release into the environment have raised a serious global concern. Pharmaceuticals remain active even at low concentrations, therefore their occurrence in waterbodies may lead to successive deterioration of water quality with adverse impacts on the ecosystem and human health. To address this challenge, there is currently an evolving trend toward the search for effective methods to ensure efficient purification of both drinking water and wastewater. Biocatalytic transformation of pharmaceuticals using oxidoreductase enzymes, such as peroxidase and laccase, is a promising environmentally friendly solution for water treatment, where fungal species have been used as preferred producers due to their ligninolytic enzymatic systems. Enzyme-catalyzed degradation can transform micropollutants into more bioavailable or even innocuous products. Enzyme immobilization on a carrier generally increases its stability and catalytic performance, allowing its reuse, being a promising approach to ensure applicability to an industrial scale process. Moreover, coupling biocatalytic processes to other treatment technologies have been revealed to be an effective approach to achieve the complete removal of pharmaceuticals. This review updates the state-of-the-art of the application of oxidoreductases enzymes, namely laccase, to degrade pharmaceuticals from spiked water and real wastewater. Moreover, the advances concerning the techniques used for enzyme immobilization, the operation in bioreactors, the use of redox mediators, the application of hybrid techniques, as well as the discussion of transformation mechanisms and ending toxicity, are addressed.

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“…Istotne znaczenie ma także P. ostreatus, który już w ciągu 4 h efektywnie wyeliminował ze środowiska sertralinę, paroksetynę, klomipraminę oraz fluoksetynę występujące w stężeniu 100 ng•ml -1 dla pojedynczego związku, gdzie stopień degradacji wyniósł odpowiednio: 91,2%, 92,8%, 86,1% oraz 86,2%. Mianseryna, występująca początkowo w tym samym stężeniu, co poprzednio wymienione API, z niemalże maksymalną wydajnością (94,0%) została usunięta po 24 h [77].…”

Section: Związki Stosowane W Chorobach Ośrodkowego Układu Nerwowegounclassified

Pozostałości Substancji Farmakologicznie Czynnych Jako Zanieczyszczenie Środowiska I Rola Grzybów Białej Zgnilizny W Ich Usuwaniu

Kózka¹,

Bębas²

2021

pps

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Obecność substancji czynnych leków w środowisku stanowi poważny problem dotyczący całego świata. Wśród związków o zastosowaniu terapeutycznym zanieczyszczających otoczenie można znaleźć przedstawicieli różnych grup substancji farmakologicznych, a w szczególności: niesteroidowych leków przeciwzapalnych, antybiotyków i innych związków biobójczych, steroidów oraz związków stosowanych w terapii schorzeń ośrodkowego układu nerwowego lub układu krwionośnego. Zanieczyszczenie takimi substancjami wynika z nieprzystosowania konwencjonalnych oczyszczalni ścieków do ich usuwania. Związki te wraz z oczyszczonymi ściekami trafiają do środowiska, gdzie stanowią zagrożenie dla organizmów (w tym człowieka), zaburzając jednocześnie ekosystemy. Z tego powodu poszukiwane są nowe metody usuwania substancji czynnych leków ze ścieków komunalnych. Jednym z nich jest zastosowanie nietaksonomicznej grupy grzybów białej zgnilizny, których zdolności do rozkładu różnych związków zostały potwierdzone w licznych badaniach. Niniejsza praca stanowi przegląd przyczyn obecności substancji czynnych leków w środowisku, związków obecnych w ściekach, ich toksycznego wpływu na organizmy, regulacji prawnych dotyczących obecności związków farmakologicznych w środowisku oraz zdolności grzybów białej zgnilizny do rozkładu substancji o znaczeniu terapeutycznym.

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Application of Pleurotus ostreatus to efficient removal of selected antidepressants and immunosuppressant

Cited by 15 publications

References 33 publications

Optimization of White-Rot Fungi Mycelial Culture Components for Bioremediation of Pharmaceutical-Derived Pollutants

Optimization of White-Rot Fungi Mycelial Culture Components for Bioremediation of Pharmaceutical-Derived Pollutants

Current Challenges for Biological Treatment of Pharmaceutical-Based Contaminants with Oxidoreductase Enzymes: Immobilization Processes, Real Aqueous Matrices and Hybrid Techniques

Pozostałości Substancji Farmakologicznie Czynnych Jako Zanieczyszczenie Środowiska I Rola Grzybów Białej Zgnilizny W Ich Usuwaniu

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