Application of Polyvinylidene Fluoride (PVDF) as a Biomaterial in Medical Textiles

Houis, Stéphanie; Engelhardt, Eva; Wurm, Florian Μ.; Gries, Thomas

doi:10.1533/9780857090348.342

Cited by 30 publications

(16 citation statements)

References 9 publications

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“…In recent years, polyvinylidene fluoride (PVDF) has appeared to be a very promising material. It can be used as a non-degradable and biocompatible polymer for medical applications [ 14 ], energy harvesting [ 15 , 16 ], pressure sensors [ 17 , 18 ], electrically activated air filters [ 19 ], or viral particles filters [ 20 ] against to novel coronavirus [ 21 ], and to other similar viruses. PVDF is semi-crystalline fluoropolymer with excellent chemical stability, high mechanical strength, thermal stability, aging resistance and moreover, having molecules with large dipole moment perpendicular to the polymer chain.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Characterization of PVDF Nanofibers at Macro- and Nanolevel

et al. 2022

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This study is focused on the characterization and investigation of polyvinylidene fluoride (PVDF) nanofibers from the point of view of macro- and nanometer level. The fibers were produced using electrostatic spinning process in air. Two types of fibers were produced since the collector speed ( 300rpm and 2000rpm) differed as the only one processing parameter. Differences in fiber’s properties were studied by scanning electron microscopy (SEM) with cross-sections observation utilizing focused ion beam (FIB). The phase composition was determined by Fourier-transform infrared spectroscopy (FTIR) and Raman spectroscopy. The crystallinity was determined by differential scanning calorimetry (DSC), and chemical analysis of fiber’s surfaces and bonding states were studied using X-ray photoelectron spectroscopy (XPS). Other methods, such as atomic force microscopy (AFM) and piezoelectric force microscopy (PFM), were employed to describe morphology and piezoelectric response of single fiber, respectively. Moreover, the wetting behavior (hydrophobicity or hydrophilicity) was also studied. It was found that collector speed significantly affects fibers alignment and wettability (directionally ordered fibers produced at 2000rpm almost super-hydrophobic in comparison with disordered fibers spun at 300rpm with hydrophilic behavior) as properties at macrolevel. However, it was confirmed that these differences at the macrolevel are closely connected and originate from nanolevel attributes. The study of single individual fibers revealed some protrusions on the fiber’s surface, and fibers spun at 300rpm had a core-shell design, while fibers spun at 2000rpm were hollow.

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Section: Introductionmentioning

confidence: 99%

Comprehensive Characterization of PVDF Nanofibers at Macro- and Nanolevel

et al. 2022

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“…The engineered bone scaffolds should be osteo-conductive so osteoblasts can proliferate and adhere, subsequently building new tissue. One of the piezoelectric and biocompatible polymers is polyvinylidene fluoride (PVDF) that has been used in the various biomedical application including bone tissue regeneration. ,, Although PVDF is negatively charged considering surface potential, it is often used as a biomaterial; for example, it has been used as vascular grafts, ligament, and artificial cornea. , It has been verified that modified β-PVDF films and their composites with positive surface potential promote higher osteoblast adhesion, proliferation, , differentiation, and bone tissue formation. ,− Also mechanically stimulated PVDF, with induced transient surface charge, enhanced cell proliferation and differentiation …”

Section: Introductionmentioning

confidence: 99%

Surface-Potential-Controlled Cell Proliferation and Collagen Mineralization on Electrospun Polyvinylidene Fluoride (PVDF) Fiber Scaffolds for Bone Regeneration

Szewczyk

Metwally

Karbowniczek

et al. 2018

ACS Biomater. Sci. Eng.

105

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This study represents the unique analysis of the electrospun scaffolds with the controlled and stable surface potential without any additional biochemical modifications for bone tissue regeneration. We controlled surface potential of polyvinylidene fluoride (PVDF) fibers with applied positive and negative voltage polarities during electrospinning, to obtain two types of scaffolds PVDF(+) and, PVDF(−). The cells’ attachments to PVDF scaffolds were imaged in great details with advanced scanning electron microscopy (SEM) and 3D tomography based on focus ion beam (FIB-SEM). We presented the distinct variations in cells shapes and in filopodia and lamellipodia formation according to the surface potential of PVDF fibers that was verified with Kelvin probe force microscopy (KPFM). Notable, cells usually reach their maximum spread area through increased proliferation, suggesting the stronger adhesion, which was indeed double for PVDF(−) scaffolds having surface potential of −95 mV. Moreover, by tuning the surface potential of PVDF fibers, we were able to enhance collagen mineralization for possible use in bone regeneration. The scaffolds built of PVDF(−) fibers demonstrated the greater potential for bone regeneration than PVDF(+), showing after 7 days in osteoblasts culture produce well-mineralized osteoid required for bone nodules. The collagen mineralization was confirmed with energy dispersive X-ray spectroscopy (EDX) and Sirius Red staining, additionally the cells proliferation with fluorescence microscopy and Alamar Blue assays. The scaffolds made of PVDF fibers with the similar surface potential to the cell membranes promoting bone growth for next-generation tissue scaffolds, which are on a high demand in bone regenerative medicine.

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“…In comparison to single layer hollow fiber membranes, dual layer hollow fiber membranes require less materials and have better membrane performance [28]. Polyvinylidene fluoride (PVDF) is a polymer that is biocompatible, non-degradable, chemically resistant, odorless, non-toxic and has a low surface tension, making it easy to clean [29]. Microfiltration, membrane bioreactors, ultrafiltration, membrane distillation, biofuels recovery, lithium-ion battery separator, gas separation and stripping and pollution removal from water are some of the technologies using PVDF as a component.…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A Removal Using Visible Light Driven Cu2O/PVDF Photocatalytic Dual Layer Hollow Fiber Membrane

et al. 2022

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Bisphenol A (BPA) is amongst the endocrine disrupting compounds (EDCs) that cause illness to humans and in this work was removed using copper (I) oxide (Cu2O) visible light photocatalyst which has a narrow bandgap of 2.2 eV. This was done by embedding Cu2O into polyvinylidene fluoride (PVDF) membranes to generate a Cu2O/PVDF dual layer hollow fiber (DLHF) membrane using a co-extrusion technique. The initial ratio of 0.25 Cu2O/PVDF was used to study variation of the outer dope extrusion flowrate for 3 mL/min, 6 mL/min and 9 mL/min. Subsequently, the best flowrate was used to vary Cu2O/PVDF for 0.25, 0.50 and 0.75 with fixed outer dope extrusion flowrate. Under visible light irradiation, 10 mg/L of BPA was used to assess the membranes performance. The results show that the outer and inner layers of the membrane have finger-like structures, whereas the intermediate section of the membrane has a sponge-like structure. With high porosity up to 63.13%, the membrane is hydrophilic and exhibited high flux up to 13,891 L/m2h. The optimum photocatalytic membrane configuration is 0.50 Cu2O/PVDF DLHF membrane with 6 mL/min outer dope flowrate, which was able to remove 75% of 10 ppm BPA under visible light irradiation without copper leaching into the water sample.

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Application of Polyvinylidene Fluoride (PVDF) as a Biomaterial in Medical Textiles

Cited by 30 publications

References 9 publications

Comprehensive Characterization of PVDF Nanofibers at Macro- and Nanolevel

Comprehensive Characterization of PVDF Nanofibers at Macro- and Nanolevel

Surface-Potential-Controlled Cell Proliferation and Collagen Mineralization on Electrospun Polyvinylidene Fluoride (PVDF) Fiber Scaffolds for Bone Regeneration

Bisphenol A Removal Using Visible Light Driven Cu2O/PVDF Photocatalytic Dual Layer Hollow Fiber Membrane

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