Application of PRF in surgical management of periapical lesions

Singh, Smita; Singh, Arunendra; Singh, Sourav; Singh, Rashmi

doi:10.4103/0975-5950.117825

Cited by 56 publications

(38 citation statements)

References 8 publications

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“…All of them were radiological diagnosed to have bilaterally impacted mandibular third molar. Smita Singh et al (2013)[11] took a sample size of 15 for their study on application of PRF in surgical management of periapical lesions. Mozzati et al (2007)[12] in their study took a sample size of 5.…”

Section: Discussionmentioning

confidence: 99%

Healing potential of platelet rich fibrin in impacted mandibular third molar extraction sockets

Dar

Shah

Najar

et al. 2018

Ann Maxillofac Surg

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Background:Healing of both hard and soft tissues have become one of the great challenges, faced in clinical research in development of bioactive surgical additives responsible for regulating inflammation and increasing healing. Platelet-rich fibrin (PRF) represents a new step in the platelet gel therapeutic concept with simplified processing minus artificial biochemical modification.Aims and Objectives:The aim of this study is to evaluate the effectiveness of PRF on soft-tissue healing and bone tissue healing in terms of postoperative pain, postoperative swelling, soft tissue healing, and the quality of bone healing at the mandibular third molar socket.Materials and Methods:A clinical study will be done on patients reporting to the Department of Oral and Maxillofacial Surgery in Government Dental College, Srinagar, requiring disimpaction of bilateral mesioangular impacted mandibular third molars in 60 patients.Results:The present prospective clinical study evaluates the effect of PRF in healing of mandibular third molar extraction sockets. There was no difference in the age gender and type of impaction between the two groups as the mean postoperative pain score (visual analog scale) was lower for the PRF group (Group A) at all points of time when compared with the control (Group B), and this was statistically significant (P < 0.05). The mean percentage swelling was lower for the PRF group (Group A) at all points of time when compared with the control (Group B). Evaluating the effect of treatments (with or without PRF) on lamina dura score shows that in both the groups at different time periods, significant (P < 0.001) difference was observed on lamina dura score.Conclusion:The results of the present study suggest that application of autologous PRF gel has a beneficial effect on the healing of extraction sockets after third molar surgery.

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Section: Discussionmentioning

confidence: 99%

Healing potential of platelet rich fibrin in impacted mandibular third molar extraction sockets

Dar

Shah

Najar

et al. 2018

Ann Maxillofac Surg

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“…Singh et al used platelet rich fibrin for stimulation and acceleration of soft tissue and bone healing with surgical procedure combined and it proved to be very successful. Six months after surgery, complete bone regeneration was found in all patients [19].…”

Section: Discussionmentioning

confidence: 87%

Clinical and radiographic outcomes of surgical management of chronic periapical lesions in multirooted teeth

Repic¹,

Repić²,

Zarić

et al. 2018

Med pregl

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Introduction. Chronic periapical lesion is a pathological process of the root apex and the surrounding alveolar bone. Granuloma, which is a term that usually describes a chronic periapical process, represents a mass of granulation tissue at the apex of a devitalized tooth. Such lesions are treated by conventional (endodontic) therapy or surgery. The aim of this study was to assess clinical and radiographic outcomes of surgical treatment of chronic periapical lesions in multirooted teeth. Material and Methods. This prospective study included 30 patients who underwent a standard Partsch surgical procedure. The root canals, without previous endodontic treatment, were obturated immidiately before surgery, or intraoperatively. The canals with short fillings or teeth with fixed prosthetics were retrogradely obturated. Zinc-phosphate cement condensed with gutta-percha cone was used for obturation. Evaluation of clinical outcomes was performed 6, 12 and 24 months after surgery, and radiographic outcomes after 12 and 24 months, respectively. Results. After surgery, a statistically significant improvements of treatment outcomes were observed between the follop-ups (p < 0.000). The overall success rate of chronic periapical lesions in multirooted teeth 24 months after surgery was 83.3% for clinical and 66.7% for radiographic outcomes. Conclusion. The results of clinical and radiographic parameters after surgical treatment outcomes in multirooted teeth were satisfying. Therefore, we may conclude that surgical treatment can be considered as a primary treatment option in the management of chronic periapical lesions.

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“…The results of the presented research indicate that the application of CGF material in oral surgery procedures such as teeth extractions reduces the intensity of post-operative alignments. Also Singh et al and Meshram et al concluded that PRF offers many advantages such as decrease of the frequency of intraoperative and postoperative bleeding, promotion of more rapid soft tissue healing and rapid vascularization of the healing tissue by delivering growth factors [7,11]. In conclusion, use of CGF in intraosseous bone defects can result in successful bone formation as it promotes faster regeneration because of gradual release of growth factors lodged in the fibrin matrix.…”

Section: Healing Process Pointsmentioning

confidence: 97%

The influence of application of concentrated growth factors on post-operative complications – in vivo split-mouth study

Gnatek¹,

Janas-Naze²

2019

jos

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Introduction: New methods of tissue regeneration revealed a new preparation called CGF -concentrated growth factors. CGF belong to the group of platelet-reach plasma preparations, obtained by blood collecting and its centrifugation. Objectives: The aim was to evaluate the influence of CGF application in post-operative soft tissue and bone defects on post-operative complications and wound healing. Material and methods: The research was conducted in twenty patients with a symmetric single tooth (single or multi-root) qualified for extraction. On one side of the dental arch, the post-operative region was filled with CGF material, while on the other side it was left to heal by standard primary intention. Pain, swelling, alveolar osteitis, use of antibiotics, analgesics intake and wound healing were evaluated in the post-operative period. Results: The risk associated with the occurrence of pain classified higher on the Numeric Rating Scale (NRS) than the given category increased 3.4 times if the alveolus was not filled with CGF (p < 0.05). The risk of swelling on a given day after surgery dropped about 44 times when CGF was applied (p < 0.05, p < 0.01, p < 0.05). In cases where the alveolus was filled with CGF, the use of the membrane reduced the risk of edema by 7.5 times in the seven-day period after surgery. Filling the alveolus with CGF resulted in a 5.7-fold decrease in the risk of having to use antibiotics after tooth extraction (p < 0.01). The possibility for complete healing of the alveolus up to the seventh day after surgery was about 5.5 times lower when the alveolus was not filled with CGF (p < 0.05). Conclusion:The filling of a post-operative defect with CGF reduces the frequency and intensity of post-operative pain, swelling, antibiotic therapy intake and the occurrence of facial edema, which improves the quality of life in the post-operative period.

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Application of PRF in surgical management of periapical lesions

Cited by 56 publications

References 8 publications

Healing potential of platelet rich fibrin in impacted mandibular third molar extraction sockets

Healing potential of platelet rich fibrin in impacted mandibular third molar extraction sockets

Clinical and radiographic outcomes of surgical management of chronic periapical lesions in multirooted teeth

The influence of application of concentrated growth factors on post-operative complications – in vivo split-mouth study

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