Application of promethazine hydrochloride as a chromogenic reagent for the spectrophotometric determination of certain sulphonamide drugs

Al-Abachi, Mouayed Q.; Salih, Elham; Salem, Mutaz S.

doi:10.1007/bf00322221

Cited by 7 publications

(2 citation statements)

References 11 publications

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“…The official methods of the British Pharmacopoeia [4] and the United States Pharmacopoeia [5] describe a nitrite titration method for the analysis of sulpha drugs. The methods available for the determination of sulphonamide derivatives include high-performance liquid chromatography [6][7][8][9][10][11], electroanalytical methods [12][13][14], and spectrophotometric methods [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Extractive spectrophotometric determination of sulphonamide drugs in pure and pharmaceutical preparations through ion-pair formation with molybdenum(V) thiocyanate in acidic medium

El-Dien

Khaled

Frag

2010

Journal of Advanced Research

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A simple and sensitive extraction-spectrophotometric method is described for the determination of sulfonamide drugs, namely sulphamethoxazole, sulphaguanidine, sulphaquinoxaline, sulphametrole and sulphadimidine, in both pure form and in the dosage forms available in Egyptian markets. The method is based on ion-pair formation between the sulphonamides and Mo(V)-thiocyanate inorganic complex in a sulphuric acid medium followed by extraction of the coloured ion-pairs with 1,2-dichloroethane. The optimum conditions are established. The method permits the determination of sulphonamide drugs over the concentration range of 5-50 g ml −1 . The Sandell sensitivity (S), molar absorptivity, correlation coefficient and regression equations, and limits of detection (LOD) and quantification (LOQ) are calculated. The law values of standard deviation (0.09-0.38) and relative standard deviation (0.10-0.550) reflect the accuracy and precision of the proposed method. The method is applicable for the assay of the investigated drugs in different dosage forms and the results are in good agreement with those obtained by the official pharmacopeial method.

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Section: Introductionmentioning

confidence: 99%

Extractive spectrophotometric determination of sulphonamide drugs in pure and pharmaceutical preparations through ion-pair formation with molybdenum(V) thiocyanate in acidic medium

El-Dien

Khaled

Frag

2010

Journal of Advanced Research

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“…An extraction-spectrophotometric determination of amyzyl, arpenal, aprofen, diamiphen, tropacin, and estocin based on their interaction with ammonium tetrathiocyanocobaltate(II) in dichloroethane has been reported (119). A number of pharmaceutically important sulfonamides have reportedly been analyzed based on their oxidative coupling with promethazine (120) and also as a result of their reaction with metol and N-chlorosuccinimide or dibromohydantoin (121). The trace analysis for anionic surfactants in mineral waters and soft drinks using ethyl violet as the chromogenic reagent has been described (122).…”

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confidence: 99%

Ultraviolet and light absorption spectrometry

Hargis¹,

Howell²

1992

Anal. Chem.

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with a B S In 1961, an M.S. in 1963. and a Ph D. in 1964. spent a year as a Postdoctoral Research Associate at Purdue University, and |olned the faculty at UNO in 1965. His present research Interests Include ultraviolet and light absorption spectrometry, reaction-rate analyses, heteropolymoiybdate chemistry, and on-line computer applications to chemical problems. He has authored or coauthored numerous research papers, an Instrumental analysis laboratory manual, an introductory analytical chemistry textbook, and chapters In several monographs dealing with spectrophotometry. Dr. Hargis holds membership in the American Chemical Society (Analytical and Education divisions). Phi Lambda Upsilon, and Sigma XI.

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Determination of sulfonamides with fluorescent inclusion complex of carbonic anhydrase and dansylamide

1998

Chin.Sci.Bull.

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Application of promethazine hydrochloride as a chromogenic reagent for the spectrophotometric determination of certain sulphonamide drugs

Cited by 7 publications

References 11 publications

Extractive spectrophotometric determination of sulphonamide drugs in pure and pharmaceutical preparations through ion-pair formation with molybdenum(V) thiocyanate in acidic medium

Extractive spectrophotometric determination of sulphonamide drugs in pure and pharmaceutical preparations through ion-pair formation with molybdenum(V) thiocyanate in acidic medium

Ultraviolet and light absorption spectrometry

Determination of sulfonamides with fluorescent inclusion complex of carbonic anhydrase and dansylamide

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