Application of purified porcine collagen in patients with chronic refractory musculoskeletal pain

Abstract

Background: This study aimed to assess the potential efficacy of purified porcine atelocollagen (PAC) for the management of refractory chronic pain due to suspected connective tissue damage. Methods: Patients treated with PAC were retrospectively evaluated. Patients with chronic refractory pain, suspected to have originated from musculoskeletal damage or defects with the evidence of imaging studies were included. Pain intensity, using the 11-point numerical rating scale (NRS), was assessed before the procedure, and 1 month after the last procedure. Results: Eighty-eight patients were finally included for investigation. The mean NRS score was decreased from 5.8 to 4.1 after 1 month of PAC injection (P < 0.001). No independent factor was reported to be directly related to the decrease in NRS score by more than half. Conclusions: Application of PAC may have potential as a treatment option for refractory chronic musculoskeletal pain. PAC might promote tissue recovery, act as a scaffold for repair, or directly reduce inflammation.

The Potential of Collagen Treatment for Comorbid Diseases

“…Purified porcine atelocollagen (PAC) showed promise as a potential treatment option for managing refractory chronic musculoskeletal pain in a study that recruited patients with chronic refractory pain, where musculoskeletal damage or defects were suspected based on evidence from imaging studies [36]. PAC has the potential to facilitate tissue recovery, act as a scaffold for repair, or directly alleviate inflammation.…”

Intra-Articular Collagen Injections for Osteoarthritis: A Narrative Review

“…The in vitro exposure of animal or human synovial and cartilage cells to collagen preparations, with different degrees of hydrolysation or polymerization, was shown to induce the up-regulation of chondrocyte proliferation and production of cartilage extracellular matrix proteins, to increase the production of hyaluronic acid, and to reduce the release of inflammatory mediators [27][28][29][30][31]. For example, purified porcine atelocollagen, a soluble type-I collagen with good biocompatibility, minor immunogenicity, a long half-life, and high resistance to enzymatic degradation, was shown to directly reduce inflammation and to promote tissue repair, acting as a scaffold for regeneration reaction around the damaged areas [32][33][34].…”