Application of rodes software to experimental biokinetic data for dose assessment in mice and rats

Abstract

H Miloudi, M Locatelli, G Autret, D Balvay, A Desbrée, E Blanchardon, J M Bertho: application of RODES software to experimental biokinetic data for dose assessment in mice and rats. In support of experimental studies of chronic, long-term contamination in rodents, voxel-based computer models were built representing adult mice and juvenile, adult and elderly rats of both sexes. RODES software was created to calculate absorbed radiation doses to organs with these specific anatomical models. Absorbed doses were then calculated starting from previously published biokinetic data. Whole body doses showed less than 5% differences between calculation with RODES and calculation with the ICRP Publication 108 model for long term exposure to Sr of mice. Similar results were obtained for long term exposure toCs. Dose distribution for Sr internal contamination also showed that the dose to the skeleton is six fold more as compared to the whole body dose while radiation dose to other organs is less than the mean whole body dose. These results underline the importance of using specific anatomical models according to the age and the sex of experimental animals.

PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates

“…Organ and tumor dosimetry calculations were performed using the Rodent Dose Evaluation Software (16,17). Briefly, pharmacokinetic data were input into a murine three-dimensional imaging-based dosimetry platform built on accurate MRI volumes to compute the intraorgan and interorgan and tumor-absorbed doses from alphaparticle, beta-particle, and gamma-emission transport.…”

Co-exposure to internal and external radiation alters cesium biokinetics and retention in mice

“…To evaluate the additional absorbed radiation dose due to 137 Cs injection, we used the RODES software (Miloudi et al 2017 with the individual whole body measurements of 137 Cs during the experiment. The results (figure 5) showed that the range of the additional dose due to 137 Cs injection estimated in each individual animal was between 7.4 mGy and 9.3 mGy, without any significant difference according to the external irradiation group.…”

PSA-targeted Alpha-, Beta- and Positron Emitting Immuno-Theranostics in Murine Prostate Cancer Models and Non-Human Primates

“…Biodistribution studies were conducted to evaluate uptake and pharmacological distribution of fPSA (16,17). Briefly, pharmacokinetic data were input into a murine hu5A10 radioimmunotheranostics 3D imaging-based dosimetry platform built on accurate magnetic resonance imaging volumes in order to compute the intra-and inter-organ and tumor absorbed doses from alpha-particle, beta-particle and gamma-emission transport.…”