2020
DOI: 10.5530/ijper.54.3.114
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Application of Similarity Factor (f2) and Time Required to Drug Release (t%) Indicators for Dissolution Profiles Comparison of Paracetamol Tablets

Abstract: Introduction: The comparison of in vitro dissolution profiles is an integral step during the development of any generic product. However, using merely similarity factor (f 2) as a dissolution parameter may not be adequate. Objectives: The present study was conducted to explore whether f 2 alone suffices to adequately compare the dissolution profiles of tablets or both f 2 and time required to percentage drug release (t %) generate closely similar results. Methods: The reference (R) and two generic paracetamol … Show more

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Cited by 4 publications
(1 citation statement)
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“…The manifestations of such conditions exacerbate in the prime morning hours as per the circadian rhythm (Buttgereit et al., 2015 ; Sunil et al., 2011 ) and require the drug to be available at that time within the therapeutic window to provide relief from the symptoms. This necessitates the drug to be released and delivered quickly within a short duration instantly after the prerequisite lag time (BaHammam et al., 2010 ; Tinny et al., 2013 ; Youan, 2010 ).…”
Section: Introductionmentioning
confidence: 99%
“…The manifestations of such conditions exacerbate in the prime morning hours as per the circadian rhythm (Buttgereit et al., 2015 ; Sunil et al., 2011 ) and require the drug to be available at that time within the therapeutic window to provide relief from the symptoms. This necessitates the drug to be released and delivered quickly within a short duration instantly after the prerequisite lag time (BaHammam et al., 2010 ; Tinny et al., 2013 ; Youan, 2010 ).…”
Section: Introductionmentioning
confidence: 99%