Poloxamer and Chitosan-Based &lt;i&gt;In Situ&lt;/i&gt; Gels Loaded with &lt;i&gt;Orthosiphon stamineus&lt;/i&gt; Benth. Extracts Containing Rosmarinic Acid for the Treatment of Ocular Infections

Zeeshan, Farrukh; Sheshala, Ravi; Wai, Ng Zing; SAID, IQBAL DANIAL; Ashraf, Kamran; Lim, Siong Meng; Ramasamy, Kalavathy

doi:10.4274/tjps.galenos.2021.40121

Cited by 8 publications

(1 citation statement)

References 42 publications

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“…The inclusion of additives can alter the gel structure, gel porosity, and mechanical and rheological properties by hydrogen bonding and hydrophobic and supramolecular interactions. Researchers have used additives such as alginates [ 105 ], chitosan [ 106 , 107 ], carrageenan [ 103 ], gellan gum [ 108 ], cellulose derivatives [ 109 ], hyaluronic acid [ 110 ], and salts such as sodium chloride [ 104 ] into in situ gels to modify the release profile of the loaded drugs. These additives can change the gel erosion and diffusion characteristics of the thermoreversible gel.…”

Section: Drug Release Mechanism From Thermoreversible In Situ Gelsmentioning

confidence: 99%

Thermosensitive In Situ Gels for Joint Disorders: Pharmaceutical Considerations in Intra-Articular Delivery

Koland

Vadakkepushpakath

John

et al. 2022

Gels

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The intra-articular administration of conventional drug solutions or dispersions in joint diseases such as osteoarthritis has a relatively short retention time and, therefore, limited therapeutic effect. Thermosensitive polymer solutions that exhibit a sol–gel phase transition near body temperature after injection can prolong drug retention by providing a depot from which the drug release is sustained while relieving inflammation and preventing degradation of the joint complex. Thermosensitive hydrogels have in recent times garnered considerable attention in the intra-articular therapeutics of joint diseases such as osteoarthritis. Among the stimuli-responsive gelling systems, most research has focused on thermosensitive hydrogels. These gels are preferred over other stimuli-sensitive hydrogels since they have well-controlled in situ gelling properties and are also easier to load with drugs. Temperature-sensitive polymers, such as block copolymers or poloxamers, are frequently used to modify their gelation properties, usually in combination with other polymers. They are compatible with most drugs but may pose formulation challenges in terms of their low-response time, highly fragile nature, and low biocompatibility. The stability and biodegradability of implant hydrogels can control the drug release rate and treatment efficacy. This review stresses the application of thermosensitive gels in joint disorders and summarizes recent developments for intra-articular application, including the incorporation of nanoparticles. The hydrogel composition, drug release mechanisms, and the challenges involved in their formulation and storage are also discussed.

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Section: Drug Release Mechanism From Thermoreversible In Situ Gelsmentioning

confidence: 99%

Thermosensitive In Situ Gels for Joint Disorders: Pharmaceutical Considerations in Intra-Articular Delivery

Koland

Vadakkepushpakath

John

et al. 2022

Gels

View full text Add to dashboard Cite

show abstract

Chitosan/carbomer nanoparticles- laden in situ gel for improved ocular delivery of timolol: in vitro, in vivo, and ex vivo study

Rahbar,

Darvish,

Farrahi

et al. 2024

Drug Deliv. and Transl. Res.

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mPEG-CS-modified flexible liposomes-reinforced thermosensitive sol-gel reversible hydrogels for ocular delivery of multiple drugs with enhanced synergism

Peng,

Zhang,

et al. 2023

Colloids and Surfaces B: Biointerfaces

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Poloxamer and Chitosan-Based <i>In Situ</i> Gels Loaded with <i>Orthosiphon stamineus</i> Benth. Extracts Containing Rosmarinic Acid for the Treatment of Ocular Infections

Cited by 8 publications

References 42 publications

Thermosensitive In Situ Gels for Joint Disorders: Pharmaceutical Considerations in Intra-Articular Delivery

Thermosensitive In Situ Gels for Joint Disorders: Pharmaceutical Considerations in Intra-Articular Delivery

Chitosan/carbomer nanoparticles- laden in situ gel for improved ocular delivery of timolol: in vitro, in vivo, and ex vivo study

mPEG-CS-modified flexible liposomes-reinforced thermosensitive sol-gel reversible hydrogels for ocular delivery of multiple drugs with enhanced synergism

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