Application of skin traction for surgical treatment of grade IV pressure sore: a clinical report of 160 cases

Chen, X; Zheng, Jiang; Chen, Z; Wang, D

doi:10.1038/sc.2010.83

Cited by 4 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent progress in material sciences has facilitated the evaluation of chemical agents, such as fibrin glue, gelatin, collagen, and hydrogels, for rapid wound healing 16 – 18 . Historically, hydrogels were pre-formed and delivered to target sites in patients, however, uneven or irregularly shaped wound surfaces are difficult to cover entirely with pre-formed biomaterials, resulting in ineffective wound healing and low cell survival for tissue remodeling 19 . Hydrogel precursors can be injected with a syringe and can be locally cross-linked by percutaneous photopolymerization 20 .…”

Section: Introductionmentioning

confidence: 99%

Photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor

Kubota

Mayumi

Nakayama

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Biomaterials traditionally used for wound healing can act as a temporary barrier to halt bleeding, prevent infection, and enhance regeneration. Hydrogels are among the best candidates for wound healing owing to their moisture retention and drug-releasing properties. Photo-polymerization using visible light irradiation is a promising method for hydrogel preparation since it can easily control spatiotemporal reaction kinetics and rapidly induce a single-step reaction under mild conditions. In this study, photocrosslinked gelatin hydrogels were imparted with properties namely fast wound adherence, strong wet tissue surface adhesion, greater biocompatibility, long-term bFGF release, and importantly, ease of use through the modification and combination of natural bio-macromolecules. The production of a gelatin hydrogel made of natural gelatin (which is superior to chemically modified gelatin), crosslinked by visible light, which is more desirable than UV light irradiation, will enable its prolonged application to uneven wound surfaces. This is due to its flexible shape, along with the administration of cell growth factors, such as bFGF, for tissue regeneration. Further, the sustained release of bFGF enhances wound healing and skin flap survival. The photocrosslinking gelatin hydrogel designed in this study is a potential candidate to enhance wound healing and better skin flap survival.

show abstract

Section: Introductionmentioning

confidence: 99%

Photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor

Kubota

Mayumi

Nakayama

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In the traditional way, hydrogels are prefabricated and placed on target wounds in patients, which may not fully cover uneven or irregular wound surfaces, resulting in ineffective wound healing and low cell survival for tissue remodeling [ 9 ]. The problem could be overcome by applying hydrogel precursors that form hydrogel in situ.…”

Section: Introductionmentioning

confidence: 99%

Development of an In Situ Photo-Crosslinking Antimicrobial Collagen Hydrogel for the Treatment of Infected Wounds

Wu,

Tsai

2023

Polymers

View full text Add to dashboard Cite

Antimicrobial hydrogels have received considerable attention in the treatment of bacteria-infected wounds. Herein, we develop a neutral, soluble collagen via modification with maleic anhydride, serving as a hydrogel precursor. Maleic anhydride-modified collagen (ColME) could form a gel after exposure to UV light and be loaded with the antimicrobial agents, nisin and levofloxacin, to acquire antimicrobial ability. The ColME hydrogel containing nisin and levofloxacin had good cytocompatibility and effectively killed pathogenic bacterial strains, such as Escherichia coli and Staphylococcus aureus. The antimicrobial ColME hydrogels effectively supported the healing of a full-thickness skin wound infected with S. aureus in a mouse model. Our results demonstrate the potential of antimicrobial hydrogels as effective wound dressings via in situ photogelation for the healing of infected wounds.

show abstract

“…In the field of surgery, we often encounter many wounds that are difficult to treat with hydrogel dressings. Traditional hydrogels exposed problems, such as inconvenient operation, short dwell time, and unstable biofixation when dealing with those wounds with an uneven or irregular shape and postoperative adhesion, resulting in a poor wound healing effect [ 34 , 35 , 36 ]. Therefore, it is still necessary to develop more ideal hydrogel materials with strong adhesion ability, better healing promotion, and better spatiotemporal controllability.…”

Section: Introductionmentioning

confidence: 99%

Effects and Progress of Photo-Crosslinking Hydrogels in Wound Healing Improvement

Peng

Zhang

et al. 2022

Gels

View full text Add to dashboard Cite

Wound healing is a dynamic physiological process, including three stages: inflammation, tissue formation, and remodeling. The quality of wound healing is affected by many topical and systemic factors, while any small factor may affect the process. Therefore, improving the quality of wound healing is a complex and arduous challenge. Photo-crosslinking reaction using visible light irradiation is a novel method for hydrogel preparation. Photo-crosslinking hydrogels can be controlled in time and space, and are not interfered by temperature conditions, which have been widely used in the fields of medicine and engineering. This review aims to summarize the application of photo-crosslinking hydrogels in improving the quality of wound healing, mainly including the material design, application mechanism, and effect of photo-crosslinking hydrogels applied in wound healing, followed by the applicable animal models for experimental research. Finally, this review analyzes the clinical application prospects of photo-crosslinking hydrogels in the field of wound healing.

show abstract

Application of skin traction for surgical treatment of grade IV pressure sore: a clinical report of 160 cases

Cited by 4 publications

References 23 publications

Photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor

Photocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor

Development of an In Situ Photo-Crosslinking Antimicrobial Collagen Hydrogel for the Treatment of Infected Wounds

Effects and Progress of Photo-Crosslinking Hydrogels in Wound Healing Improvement

Contact Info

Product

Resources

About