Application of stem cell/growth factor system, as a multimodal therapy approach in regenerative medicine to improve cell therapy yields

Pourrajab, Fatemeh; Zarch, Mojtaba Babaei; Yazdi, Mohammad Baghi; Zarchi, Abolfazl Rahimi; Zarch, Abbas Vakili

doi:10.1016/j.ijcard.2014.02.006

Cited by 25 publications

(26 citation statements)

References 75 publications

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“…4–6 Stem cells or their derivatives have prolonged proliferation ability, multilineage differentiation potential, and trophic functions, which together enhance tissue repair while being integrated in injured tissues. 7–9 Therefore, the use of stem cells in cell therapy has been extensively studied recently.…”

Section: Introductionmentioning

confidence: 99%

Preconditioning Stem Cells for In Vivo Delivery

Sart

2014

BioResearch Open Access

162

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Stem cells have emerged as promising tools for the treatment of incurable neural and heart diseases and tissue damage. However, the survival of transplanted stem cells is reported to be low, reducing their therapeutic effects. The major causes of poor survival of stem cells in vivo are linked to anoikis, potential immune rejection, and oxidative damage mediating apoptosis. This review investigates novel methods and potential molecular mechanisms for stem cell preconditioning in vitro to increase their retention after transplantation in damaged tissues. Microenvironmental preconditioning (e.g., hypoxia, heat shock, and exposure to oxidative stress), aggregate formation, and hydrogel encapsulation have been revealed as promising strategies to reduce cell apoptosis in vivo while maintaining biological functions of the cells. Moreover, this review seeks to identify methods of optimizing cell dose preparation to enhance stem cell survival and therapeutic function after transplantation.

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Section: Introductionmentioning

confidence: 99%

Preconditioning Stem Cells for In Vivo Delivery

Sart

2014

BioResearch Open Access

162

142

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“…Consistent data indicate that the quiescent state of EPCs is rapidly reversed in response to growth factors; VEGF and IGF‐1, the robust switchers of quiescent c‐Kit + PCs towards the activation state 71, 72, 73. IGF‐1 protects c‐Kit + stem cells against ROS‐induced mitochondrial dysfunction and inhibits mitochondrial‐induced apoptosis, through PI3K/Akt pathway 72.…”

Section: Some Mirna Key Mechanisms In Reparative Angiogenesismentioning

confidence: 83%

MicroRNAs; easy and potent targets in optimizing therapeutic methods in reparative angiogenesis

Pourrajab

Zarch

Hekmatimoghaddam

et al. 2015

J Cellular Molecular Medi

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The age‐related senescence of adult tissues is associated with the decreased level of angiogenic capability and with the development of a degenerative disease such as atherosclerosis which thereafter result in the deteriorating function of multiple systems. Findings indicate that tissue senescence not only diminishes repair processes but also promotes atherogenesis, serving as a double‐edged sword in the development and prognosis of ischaemia‐associated diseases. Evidence evokes microRNAs (miRNAs) as molecular switchers that underlie cellular events in different tissues. Here, miRNAs would promote new potential targets for optimizing therapeutic methods in blood flow recovery to the ischaemic area. Effectively beginning an ischaemia therapy, a more characteristic of miRNA changes in adult tissues is prerequisite and in the forefront. It may also be a preliminary phase in treatment strategies by stem cell‐based therapy.

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“…The IGF-1/IRS1/PI3K/Akt pathway downstream effector FOXO is the most relevant one attributable to longevity in mammalians and in human Pourrajab et al, 2014aPourrajab et al, , 2014b. A growing number of evidence link FOXO to longevity and to chromatin-remodeling system PARP1/SIRT1 which also controls trophic and bioenergetic pathways (Rodier and Campisi, 2011;Gorospe and Abdelmohsen, 2011;Zhao et al, 2010).…”

Section: A Brief Introduction To the Signaling Pathways Involved In Cmentioning

confidence: 99%

“…The Akt pathway positively regulates cell cycle progression and proliferation by reducing the expression levels of critical cell cycle inhibitors p53/p21/p16 Gorospe and Abdelmohsen, 2011;Pourrajab et al, 2014aPourrajab et al, , 2014b.…”

Section: A Brief Introduction To the Signaling Pathways Involved In Cmentioning

confidence: 99%

“…Interestingly, down-regulated SA-miR-17-92 emerges as one of the major difference between adult CSCs and their primary progenitor populations Noren Hooten et al, 2010;Pourrajab et al, 2014aPourrajab et al, , 2014b, which is commonly associated with stem cell re-growth and proliferation . Therefore, miR-17-92 cluster appears as a reprogramming switcher whose up-regulation is clearly associated with cell renovation/proliferation or reversely its downregulation brings heart to senescence (van Almen et al, 2011;Bagnall et al, 2012).…”

mentioning

confidence: 99%

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