Application of subject-specific helmets for the study of human visuomotor behavior using transcranial focused ultrasound: a pilot study

Park, Tae Young; Jeong, Ji Hyeok; Chung, Yong An; Yeo, Sang Hoon; Kim, Hyung-Min

doi:10.1016/j.cmpb.2022.107127

Cited by 10 publications

(5 citation statements)

References 52 publications

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“…In similar tFUS studies, Park et al compared duty cycle and sonication duration by used a single exploration of ultrasound parameters, focusing on assessing the feasibility of ultrasound framework ( Park et al, 2022 ). Furthermore, we focused on numerical simulation results of the effect of sonication beam parameters on the intracranial target region.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies by Nelson and Nunneley (1998) and Park et al (2022) had investigated the safety of sonication stimulation based on thermal variation, using duration of stimulation versus depth. In this study, we took a different approach by performing real-time detection of the intracranial temperature of each precision model, using assigned thermal diffusion coefficients (i.e., specific heat capacity and thermal conductivity) to the cerebrospinal fluid and skull layer, indicated that most of the heat generated within short-term sonication stimulation was absorbed by the skull layer.…”

Section: Discussionmentioning

confidence: 99%

“…Heger et al have simulated sonication acoustic fields by modifying transducer components to evaluate the potential application of targeted FUS systems in animals sensitive to cerebral hemorrhage ( Grudzenski et al, 2022 ). Park’s numerical approach based on subject-specific sonication beamline simulations to find the optimal configuration of ultrasound probes for sonication stimulation has demonstrated that the specific tFUS framework he developed can be effectively used for human neuromodulation studies ( Park et al, 2022 ). Shen’s study on the effect of low-frequency sonication (21 kHz, 26 mW/cm 2 , 40% duty cycle, 3 min) combined with microbubbles on nude mice with subcutaneous prostate adenoma showed a loss of blood flow signal at the tumor and a decrease in tumor volume ( Shen et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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A transducer positioning method for transcranial focused ultrasound treatment of brain tumors

Gao,

Sun,

Zhang

et al. 2023

Front. Neurosci.

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PurposeAs a non-invasive method for brain diseases, transcranial focused ultrasound (tFUS) offers higher spatial precision and regulation depth. Due to the altered path and intensity of sonication penetrating the skull, the focus and intensity in the skull are difficult to determine, making the use of ultrasound therapy for cancer treatment experimental and not widely available. The deficiency can be effectively addressed by numerical simulation methods, which enable the optimization of sonication modulation parameters and the determination of precise transducer positioning.MethodsA 3D skull model was established using binarized brain CT images. The selection of the transducer matrix was performed using the radius positioning (RP) method after identifying the intracranial target region. Simulations were performed, encompassing acoustic pressure (AP), acoustic field, and temperature field, in order to provide compelling evidence of the safety of tFUS in sonication-induced thermal effects.ResultsIt was found that the angle of sonication path to the coronal plane obtained at all precision and frequency models did not exceed 10° and 15° to the transverse plane. The results of thermal effects illustrated that the peak temperatures of tFUS were 43.73°C, which did not reach the point of tissue degeneration. Once positioned, tFUS effectively delivers a Full Width at Half Maximum (FWHM) stimulation that targets tumors with diameters of up to 3.72 mm in a one-off. The original precision model showed an attenuation of 24.47 ± 6.13 mm in length and 2.40 ± 1.42 mm in width for the FWHM of sonication after penetrating the skull.ConclusionThe vector angles of the sonication path in each direction were determined based on the transducer positioning results. It has been suggested that when time is limited for precise transducer positioning, fixing the transducer on the horizontal surface of the target region can also yield positive results for stimulation. This framework used a new transducer localization method to offer a reliable basis for further research and offered new methods for the use of tFUS in brain tumor-related research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A transducer positioning method for transcranial focused ultrasound treatment of brain tumors

Gao,

Sun,

Zhang

et al. 2023

Front. Neurosci.

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“…In a study by Kim and colleagues (2022) [51], tFUS applied to the medial PFC differentially changed EEG spectral power depending on the chosen acoustic parameters, which induced either excitatory or suppressive effects. Park et al ( 2022) [52] demonstrated that tFUS targeting the left dorsolateral PFC (DLPFC) effectively reduced error rates in anti-saccade tasks, but not latencies.…”

Section: Frontal Cortexmentioning

confidence: 99%

A review of functional neuromodulation in humans using low-intensity transcranial focused ultrasound

Lee,

Park,

Lee

et al. 2024

Biomed. Eng. Lett.

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Transcranial ultrasonic neuromodulation is a rapidly burgeoning field where low-intensity transcranial focused ultrasound (tFUS), with exquisite spatial resolution and deep tissue penetration, is used to non-invasively activate or suppress neural activity in specific brain regions. Over the past decade, there has been a rapid increase of tFUS neuromodulation studies in healthy humans and subjects with central nervous system (CNS) disease conditions, including a recent surge of clinical investigations in patients. This narrative review summarized the findings of human neuromodulation studies using either tFUS or unfocused transcranial ultrasound (TUS) reported from 2013 to 2023. The studies were categorized into two separate sections: healthy human research and clinical studies. A total of 42 healthy human investigations were reviewed as grouped by targeted brain regions, including various cortical, subcortical, and deep brain areas including the thalamus. For clinical research, a total of 22 articles were reviewed for each studied CNS disease condition, including chronic pain, disorder of consciousness, Alzheimer's disease, Parkinson's disease, depression, schizophrenia, anxiety disorders, substance use disorder, drug-resistant epilepsy, and stroke. Detailed information on subjects/cohorts, target brain regions, sonication parameters, outcome readouts, and stimulatory efficacies were tabulated for each study. In later sections, considerations for planning tFUS neuromodulation in humans were also concisely discussed. With an excellent safety profile to date, the rapid growth of human tFUS research underscores the increasing interest and recognition of its significant potential in the field of non-invasive brain stimulation (NIBS), offering theranostic potential for neurological and psychiatric disease conditions and neuroscientific tools for functional brain mapping.

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“…Therefore, the number of human-based studies is rapidly growing. While many of them enlighten the processes which underpin FUS (increased cortical excitability [11][12][13][14][15] through GABA inhibition [16]; brain activity in the target region could be either increased [12,[17][18][19][20][21] or decreased [22]; altered functional connectivity [13,16,17,23,24]; increased NMDA-dependent synaptic plasticity [25]), others already moved into more complex research on behavioural changes (sensory discrimination [18,[26][27][28]; motor inhibition [11,[29][30][31]; reaction time [32]; approach and withdrawal behaviours [33]; mood [24]; pain [34]; fear [35]), and the more audacious focused on pathological conditions (epilepsy[36-38]; Alzheimer's disease [39] and other dementia [40]; consciousness disorders [41]; tremor [42]; Parkinson's disease [43]; depression [44]; chronic pain [45]). However, FUS outcomes remain complex to interpret due to an incomplete understanding of the mechanisms involved.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Changes in Human Brain Connectivity Following Ultrasound Neuromodulation

Atkinson-Clement,

Alkhawashki,

Gatica

et al. 2024

Preprint

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Non-invasive neuromodulation represents a major opportunity for brain and mental health interventions. Based on its ability to target deep-brain structures, transcranial focused ultrasound neuromodulation is the most promising approach, destined to change clinical practice. However, some challenges prevent the community from fully understanding its outcomes and therefore moving to the next research step. Here we addressed one of them and unravelled the temporal dynamics of the ultrasound neuromodulation effects in humans. Our findings reveal that the effects of ultrasound neuromodulation are predominantly time-constrained and spatially distributed in brain regions functionally connected with the directly stimulated area. Furthermore, these biological effects are indicative of behavioural changes that persist for at least an hour following stimulation. Our study provides a detailed understanding of how ultrasound stimulation alters brain function over time. This is a first step towards the future prediction of the dynamic effects of ultrasound neuromodulation in terms of brain activity and behaviour, including both immediate (recorded during the stimulation) and long-term consequences (hours or days after the stimulation) of ultrasound neuromodulation.

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Application of subject-specific helmets for the study of human visuomotor behavior using transcranial focused ultrasound: a pilot study

Cited by 10 publications

References 52 publications

A transducer positioning method for transcranial focused ultrasound treatment of brain tumors

A transducer positioning method for transcranial focused ultrasound treatment of brain tumors

A review of functional neuromodulation in humans using low-intensity transcranial focused ultrasound

Dynamic Changes in Human Brain Connectivity Following Ultrasound Neuromodulation

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