Application of Successive and Progressive Spectrophotometric Resolution for the Analysis of Partially or Completely Overlapping Ternary Mixtures

Ultraviolet spectrophotometric methods for the determination of the minor component presented in fixed-dose pharmaceutical combinations through the last two decades (2000–2020)

“…These methods handle with ratio spectra by different strategies like subtraction, multiplication, factor calculation, mean centering, and derivative in order to resolve the interference between the components in the mixture, and in many cases, these methods have the ability of determining each component in zero-order, so we could get the spectral profile of each component, and that acts as a fingerprint determination. This ability gives these methods a great advantage over the other ones because they cannot only determine the compounds in the mixture, but also eliminate interference with excipients that exhibit UV absorbance and that may hinder the determination of the components of the mixture [19][20][21][22][23][24][25].…”

Eco-friendly spectrophotometric evaluation of triple-combination therapies in the treatment strategy of patients suffering from hypertension during coronavirus pandemic – Spectralprint recognition study

“…Mathematical spectrophotometric methods using built in spectrophotometer’s software are now being utilized more frequently for evaluation of drugs in pharmaceutical formulations [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] owing to their inherent benefits such as simplicity, accuracy, reduction of expensive reagents and eschewing of time consuming or special software. The objective of the current study was to develop a simple, precise, eco-friendly and economical parent spectrum resolution (PSR) manner for concurrent evaluation of VAL,AML and HCT in their triple antihypertensive medicines with trade name Exforge HCT® tablets with critical ratios so, sample enrichment technique [47] , [50] should be applied to increase the concentration of the minor component .The innovative PSR manner including novel methods namely, absorbance extraction (AE), peak-amplitude extraction (PE) and ratio extraction (RE) coupled with well-established constant multiplication (CM) and spectrum subtraction methods (SS) allowing the extraction of the parent absorption spectra (D 0 ) of the studied drugs, separately. In addition, a comparable study has been conducted between the results attained by the proposed methods versus those attained by official and reported methods to ascertain the efficiency.…”

Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture

“…1a acts as a sympathomimetic agent so it could be used as a decongestant drug [1]. Various spectrophotometric methods were established for the determination of pseudoephedrine [2][3][4]. Several chromatographic methods were applied for the determination of PSE containing HPLC [5][6][7][8][9][10], HPTLC [11][12][13], GC [14,15], and CE [16,17], and also, many electrochemical methods were reported [18][19][20].…”

“…One of their major side effects is the sedating effect which makes restriction for their use and so second-generation antihistamines commonly prescribed now. Loratadine (LOR) [ethyl 4-(8-chloro-5, 6 -dihydro-11H-benzo 5, 6 cyclohepta [1,2] pyridin-11-ylidene)-1-piperidinecarboxylate] as in Fig. 1b is a non-sedating, long-acting secondgeneration H 1 receptor blocker.…”

“…Various methods were established for analysis of LOR and its metabolite (desloratadine) in pharmaceutical formulations and in plasma of human containing spectrophotometric methods [2,21,22] and chromatographic methods including HPLC [6,9,[23][24][25], HPTLC [12,13,26], and GC [27,28]. In addition, several electrochemical and polarographic methods were reported [29][30][31][32].…”