Application of surfactants in solid dispersion technology for improving solubility of poorly water soluble drugs

Chaudhari, Smruti P.; Dugar, Rohit P.

doi:10.1016/j.jddst.2017.06.010

Cited by 128 publications

(71 citation statements)

References 77 publications

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“…Meanwhile, the use of JFC decreased the interfacial tension of trypsin solution ( Fig. 7b) and might increase the solubility and stability of trypsin in solution, which improved the wettability of trypsin solution and promoted the penetration of trypsin into pelt [32,33], so that the transfer rate of trypsin in pelt was enhanced. As for the use of AS, the zeta potential data in Fig.…”

Section: The Effect Of Auxiliaries On Bating Performancementioning

confidence: 99%

Factors affecting mass transfer of protease in pelt during enzymatic bating process

Song

Yang

et al. 2019

J Leather Sci Eng

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Bating pelt with protease is an important process, which removes unwanted non-collagenous proteins from the pelt and moderately disperse hide collagen network. However, the grain surface, may be excessively hydrolyzed during bating due to the longer retention time of protease in the grain than in the middle layer caused by the low mass transfer rate of protease in pelt. Here, the effects of protease dosage, common auxiliaries and molecular weight of protease on protease transfer during bating were investigated so that we can find the key points to avoid excessive collagen damage, particularly in the grain. Observably, increasing protease dosage led to faster protease transfer and softer leather, but along with more considerable grain damage. Using penetrating agent JFC (fatty alcohol-polyoxyethylene ether) and ammonium sulfate enhanced protease transfer and simultaneously alleviated collagen damage due to the decrease in interfacial tension and electrostatic attraction between protease and pelt, respectively. Additionally, proteases with lower molecular weight transferred faster in pelt, which suggests that a potential strategy to solve the conflict between the mass transfer and the reaction of protease in pelt might be to produce/employ smaller bating proteases.

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Section: The Effect Of Auxiliaries On Bating Performancementioning

confidence: 99%

Factors affecting mass transfer of protease in pelt during enzymatic bating process

Song

Yang

et al. 2019

J Leather Sci Eng

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“…Furthermore, the use of surfactants in solid dispersions can prevent drug precipitation in the aqueous medium. However, caution must be employed in selecting the surfactant because in some cases it can interact with polymer and thereby increase drug recrystallization [13,34,42].…”

Section: Third-generation Solid Dispersionsmentioning

confidence: 99%

“…Examples of surfactants used in third-generation solid dispersions are poloxamer 407, poloxamer 188, Compritol ® 888 ATO, Gelucire ® 44/14, Inutec ® SP1 [13,34], Soluplus ® , sodium lauryl sulfate (SLS), polysorbate 80, polyoxyethylene hydrogenated castor oil [34,42].…”

Section: Third-generation Solid Dispersionsmentioning

confidence: 99%

Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology

et al. 2018

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The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of the Biopharmaceutics Classification System). One of the most effective strategies to overcome poor dissolution rate and low absorption of drugs is the solid dispersion technique, however, although it has been the focus of much research in recent decades, there are relatively few commercially available products based on such technology. This is mainly due to problems related to production scale-up and physicochemical instability and creates opportunities for new studies to explore the full potential of the technology. This review presents an overall approach to the factors affecting the dissolution rate and oral bioavailability of BCS-classes II and IV drugs and a brief review of the state-of-the-art of solid dispersion technology.

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“…They found that, among the studied plasticizers, triethanolamine most increased the amorphization rate of the drug in the examined formulations [21]. However, sometimes, the use of surfactants causes the opposite effect, and it leads to recrystallization of the drug during storage in the amorphous solid dispersion (ASD) caused by the supersaturation of the formulation fibers [22], or enhanced molecular mobility, which is crucial in ASDs [23]. The effect of nanoscale confinement on the drug release properties of polymer nanofibers was investigated by analysis of the molecular mobility and drug release kinetics of cellulose acetate/sulindac nanofibers.…”

Section: Introductionmentioning

confidence: 99%

Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers

et al. 2020

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Electrospun nanofibers were prepared from furosemide-containing hydroxypropyl cellulose and poly(vinylpyrrolidone) aqueous solutions using different solubility enhancers. In one case, a solubilizer, triethanolamine, was applied, while in the other case a pH-modifier, sodium hydroxide, was applied. Scanning electron microscopy (SEM) was carried out for morphological characterization of the fibers. The SEM images indicated similar mean diameter size of the two fibrous formulations. However, in contrast to the NaOH-containing fibers of normal diameter distribution, the triethanolamine-containing fibers showed approximately normal diameter distribution, possibly due to their plasticizing effect and the consequent slightly ribbon-like morphology. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), powder X-ray diffraction (XRD) and positron annihilation lifetime spectroscopy (PALS) were applied for microstructural characterization. The FTIR measurements confirmed that furosemide salt was formed in both cases. There was no sign of any crystallinity based on the XRD measurements. However, the PALS highlighted the differences in the average o-Ps lifetime values and distributions of the furosemide-loaded fibrous formulations. The two types of electrospun nanofibrous formulations containing amorphous furosemide salt showed similar macrostructures but different microstructural characteristics depending on the type of solubility enhancers, which lead to altered storage stability.

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Application of surfactants in solid dispersion technology for improving solubility of poorly water soluble drugs

Cited by 128 publications

References 77 publications

Factors affecting mass transfer of protease in pelt during enzymatic bating process

Factors affecting mass transfer of protease in pelt during enzymatic bating process

Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology

Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers

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